Carine Baraguey
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Carine Baraguey has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Jean-Jacques Vasseur
Institut des Biomolécules Max Mousseron Université de Montpellier, CNRS, ENSCM Montpellier France
2 shared publications - Eveline Lescrinier
KU Leuven
1 shared publication - Françoise Debart
IBMM, University of Montpellier, CNRS, ENSCM, Montpellier, France
1 shared publication - Michael Smietana
Institut des Biomolécules Max Mousseron
1 shared publication - Piet Herdewijn
KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49, 3000 Leuven, Belgium
1 shared publication Renaud Barbeyron
1 shared publication
Latest Publications
- 1 April 2017
- Published by Elsevier in Tetrahedron
- Vol. 73 (17) , 2468-2475
Synthesis of 3′-deoxy-3′-iminodiacetic acid and 3′-deoxy-3′-aminodiethanol thymidine analogues and NMR study of their complexation with boronic acids
- 1 April 2017
- Published by Elsevier in Tetrahedron
- Vol. 73 (17) , 2468-2475
Synthesis of 3′-deoxy-3′-iminodiacetic acid and 3′-deoxy-3′-aminodiethanol thymidine analogues and NMR study of their complexation with boronic acids
- 12 February 2013
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 11 (16) , 2638-2647
The biolabile 2′-O-pivaloyloxymethyl modification in an RNA helix: an NMR solution structure
The pivaloyloxymethyl (PivOM) group is a biolabile 2′-O-ribose protection that is under development in a prodrug-based approach for siRNA applications. Besides an expected cellular uptake, nucleic acid sequences carrying PivOM showed also increased nuclease resistance and, in most cases, an affinity for complementary RNA. The r(CGCU*ACGC)dT:r(GCGUAGCG)dT model duplex containing a single modified residue (U*) was synthesized and its solution structure was determined by NMR. The duplex showed a maintained A-RNA helix. In U*, both 2′-O-acetal ester side chain and ring pucker presented a notable rigid conformation. The PivOM moiety was oriented with the carbonyl group turned outside the minor groove and with trans, -ac and -ac torsion angles around the C2′–O2′, O2′–CA and CA–OB1 bonds respectively. Gauche effects and dipolar interactions between the PivOM and the backbone appeared to be the predominant factors influencing the PivOM conformation and the orientation of the two supplementary H acceptors suggested that hydration could also play a role in the duplex stability.
- 12 February 2013
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 11 (16) , 2638-2647
The biolabile 2′-O-pivaloyloxymethyl modification in an RNA helix: an NMR solution structure
The pivaloyloxymethyl (PivOM) group is a biolabile 2′-O-ribose protection that is under development in a prodrug-based approach for siRNA applications. Besides an expected cellular uptake, nucleic acid sequences carrying PivOM showed also increased nuclease resistance and, in most cases, an affinity for complementary RNA. The r(CGCU*ACGC)dT:r(GCGUAGCG)dT model duplex containing a single modified residue (U*) was synthesized and its solution structure was determined by NMR. The duplex showed a maintained A-RNA helix. In U*, both 2′-O-acetal ester side chain and ring pucker presented a notable rigid conformation. The PivOM moiety was oriented with the carbonyl group turned outside the minor groove and with trans, -ac and -ac torsion angles around the C2′–O2′, O2′–CA and CA–OB1 bonds respectively. Gauche effects and dipolar interactions between the PivOM and the backbone appeared to be the predominant factors influencing the PivOM conformation and the orientation of the two supplementary H acceptors suggested that hydration could also play a role in the duplex stability.