Jianzhong Xi
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Jianzhong Xi has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
B. Chu
Department of Bioengineering, University of California at Los Angeles (UCLA), 7523 Boelter Hall, Los Angeles, CA 90095, USA
1 shared publicationCarlo D. Montemagno
University of California Los Angeles
1 shared publication- Carlo D. Montemagno
University of California Los Angeles
1 shared publication D. Ho
Department of Bioengineering, University of California at Los Angeles (UCLA), 7523 Boelter Hall, Los Angeles, CA 90095, USA
1 shared publicationJacob J. Schmidt
University of California Los Angeles
1 shared publication
Latest Publications
- 25 July 2005
- Published by Wiley in Advanced Functional Materials
- Vol. 15 (8) , 1233-1240
Lessons Learned from Engineering Biologically Active Hybrid Nano/Micro Devices
Engineering devices based upon the interfacing of biological with inorganic systems have led to fascinating research results and present important implications for next‐generation technologies. The development of cell‐ and protein‐based micro/nano systems has demonstrated that several key factors must be considered when establishing fabrication rules. These include material interface properties, preserving biological viability, as well as self‐assembly as a device‐fabrication methodology, to name a few. Here, we present two proposed devices that have been developed through the application of these principles. They include muscle‐powered microfabricated devices, as well as protein‐functionalized polymeric vesicles based on protein‐coupling reactions. These systems have successfully bridged the gap between biological and conventional engineering to yield exciting prospects, as well as important lessons and questions for the development of cell‐/protein‐based hybrids.
- 25 July 2005
- Published by Wiley in Advanced Functional Materials
- Vol. 15 (8) , 1233-1240
Lessons Learned from Engineering Biologically Active Hybrid Nano/Micro Devices
Engineering devices based upon the interfacing of biological with inorganic systems have led to fascinating research results and present important implications for next‐generation technologies. The development of cell‐ and protein‐based micro/nano systems has demonstrated that several key factors must be considered when establishing fabrication rules. These include material interface properties, preserving biological viability, as well as self‐assembly as a device‐fabrication methodology, to name a few. Here, we present two proposed devices that have been developed through the application of these principles. They include muscle‐powered microfabricated devices, as well as protein‐functionalized polymeric vesicles based on protein‐coupling reactions. These systems have successfully bridged the gap between biological and conventional engineering to yield exciting prospects, as well as important lessons and questions for the development of cell‐/protein‐based hybrids.
- Top Cited Papers
- 16 January 2005
- Published by Springer Nature in Nature Materials
- Vol. 4 (2) , 180-184
Self-assembled microdevices driven by muscle
Current procedures for manual extraction of mature muscle tissue in micromechanical structures are time consuming and can damage the living components. To overcome these limitations, we have devised a new system for assembling muscle-powered microdevices based on judicious manipulations of materials phases and interfaces. In this system, individual cells grow and self-assemble into muscle bundles that are integrated with micromechanical structures and can be controllably released to enable free movement. Having realized such an assembly with cardiomyocytes we demonstrate two potential applications: a force transducer able to characterize in situ the mechanical properties of muscle and a self-assembled hybrid (biotic/abiotic) microdevice that moves as a consequence of collective cooperative contraction of muscle bundles. Because the fabrication of silicon microdevices is independent of the subsequent assembly of muscle cells, this system is highly versatile and may lead to the integration of cells and tissues with a variety of other microstructures.
- 16 January 2005
- Published by Springer Nature in Nature Materials
- Vol. 4 (2) , 180-184
Top Cited PapersSelf-assembled microdevices driven by muscle
Current procedures for manual extraction of mature muscle tissue in micromechanical structures are time consuming and can damage the living components. To overcome these limitations, we have devised a new system for assembling muscle-powered microdevices based on judicious manipulations of materials phases and interfaces. In this system, individual cells grow and self-assemble into muscle bundles that are integrated with micromechanical structures and can be controllably released to enable free movement. Having realized such an assembly with cardiomyocytes we demonstrate two potential applications: a force transducer able to characterize in situ the mechanical properties of muscle and a self-assembled hybrid (biotic/abiotic) microdevice that moves as a consequence of collective cooperative contraction of muscle bundles. Because the fabrication of silicon microdevices is independent of the subsequent assembly of muscle cells, this system is highly versatile and may lead to the integration of cells and tissues with a variety of other microstructures.