Fazlul Karim

A registry data-based study of 3600 patients systematically drawn from out-patient clinic, laboratory and tuberculosis (TB) treatment registers (1200 from each) examined female-male differences at various clinical steps of TB management and compared selective indicators with published results. Female-to-male ratios (FMR) declined at the following clinical steps: respiratory patients seeking out-patient care (0.81), TB suspects submitting sputum for testing (0.52) and smear-positive test results (0.38), but the decline ceased at treatment Initiation (0.41). Compared to 1997, the FMR in 2000 had decreased for out-patient clinics and sputum submission for testing, but had increased for smear-positive test results and treatment initiation. More female than male patients who underwent treatment achieved cure 93% vs. 89%,). Lower female representation at the different clinical steps of TB management persists.

TB control programmes in Bangladesh, India and Malawi. To identify and compare socio-cultural features of tuberculosis (TB) and the distribution of TB-related experiences, meanings and behaviours with reference to gender across cultures in three high-endemic low-income countries. Approximately 100 patients at three sites were interviewed with in-depth semi-structured Explanatory Model Interview Catalogue (EMIC) interviews inquiring about patterns of distress, perceived causes and help-seeking behaviours in the context of illness narratives. Female patients reported more diverse symptoms and men more frequently focused on financial concerns. Most patients reported psychological and emotional distress. Men emphasised smoking and drinking alcohol as causes of TB, and women in Malawi reported sexual causes associated with HIV/AIDS. In Bangladesh, exaggerated concerns about the risk of spread despite treatment contributed to social isolation of women. Public health services were preferred in Malawi, and private doctors in India and Bangladesh. Cross-site analysis of these studies has identified features of TB that influence the burden of disease and are likely to affect timely help seeking and adherence to treatment. Health systems benefit from sex-disaggregated epidemiological data complemented by cultural epidemiological study, which together clarify the role of gender and contribute to the knowledge base for TB control at various levels.

Tuberculosis (TB) control programmes in Bangladesh, India and Malawi. To compare the interval from symptom onset to diagnosis of TB for men and women, and to assess socio-cultural and gender-related features of illness explaining diagnostic delay. Semi-structured Explanatory Model Interview Catalogue (EMIC) interviews were administered to 100 or more patients at each site, assessing categories of distress, perceived causes and help seeking. Based on time from initial symptoms to diagnosis of TB, patients were classified with problem delay (>90 days), timely diagnosis (< or =30 days) or moderate delay. EMIC interview data were analysed to explain problem delay. The median interval from symptom onset to diagnosis was longest in India and shortest in Malawi. With adjustment for confounding, female sex (Bangladesh), and status of married woman (India) and housewife (Malawi) were associated with problem delay. Prominent non-specific symptoms--chest pain (Bangladesh) and breathlessness (Malawi)--were also significant. Cough in India, widely associated with TB, was associated with timely diagnosis. Sanitation as a perceived cause linked to poor urban conditions was associated with delayed diagnosis in India. Specific prior help seeking with circuitous referral patterns was identified. The study identified gender- and illness-related features of diagnostic delay. Further research distinguishing patient and provider delay is needed.

Tuberculosis (TB) control programmes in Bangladesh, India, Malawi and Colombia. Assess indicators of TB-related stigma and socio-cultural and gender-related features of illness associated with stigma. Semi-structured Explanatory Model Interview Catalogue (EMIC) interviews were administered to 100 or more patients at each site, assessing categories of distress, perceived causes and help seeking. Indicators of self-perceived stigma were analysed individually and in a validated index, which was compared across sites and between men and women at each site. Cultural epidemiological explanatory variables for stigma and interactions with female sex were analysed at each site. Qualitative illness narratives were examined to explain the role and context of explanatory variables. The overall stigma index was highest in India, lowest in Malawi and greater for women in Bangladesh. In India and Malawi, women were more likely to be concerned about impact on marital prospects. Associations with HIV/AIDS were linked to TB stigma in Malawi, where sexual contact as a perceived cause was more associated with stigma for men and less for women. Stigma both influences and indicates the effectiveness of TB control. Cultural epidemiological methods clarify cross-cutting and local features of stigma and gender for TB control.

In addition to marginalization by poverty and ethnicity, gender is likely to contribute to vulnerability to TB-related stigma affecting women. Stigma often contributes to psychosocial problems and emotional suffering, and it may hinder help seeking and treatment adherence. TB-related stigma and its gender-specific features have not been carefully studied in Bangladesh, and such research is needed to reduce adverse effects of stigma. This study assessed and compared stigma in women and men, and identified crosscutting and gender-specific features of TB-related stigma. To assess stigma and the context of TB-related illness experience, meaning and help seeking behavior from patients’ perspectives, a cultural epidemiological study administered a locally adapted semi-structured EMIC interview to 50 women and 52 men with pulmonary TB in rural Bangladesh. Indicators of TB-related stigma were assessed individually and collectively in a validated index. They were compared by sex, and illness narratives elaborated features of stigma with reference to features of TB. The study showed that six indicators of TB-related stigma were more prominent in accounts of women and two were more prominent in men's interviews. Gender differences appeared somewhat less after adjusting for other sociodemographic variables, and age was most significantly inversely related to stigma. Features of stigma more prominent in the accounts of women included feeling shamed or embarrassed, thinking less of themselves and feeling that others refused to visit or avoided them. Men were less likely to disclose their condition to a confidant, stay away from work or report that their spouse refused sex because of TB. Effective public health information and counselling sensitive to gender-specific features of stigma are needed to protect TB patients from the adverse impact of avoidable stigma. Further research is needed to clarify effects of gender-specific features of felt and enacted stigma on help seeking and treatment adherence.