E Melen
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
E Melen has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Göran Pershagen
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
2 shared publications - Juha Kere
Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland
2 shared publications A Lindstedt
Clinical Research Centre, Karolinska University Hospital, Huddinge, Sweden
1 shared publicationF Nyberg
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
1 shared publicationH Gullstén
Clinical Research Centre, Karolinska University Hospital, Huddinge, Sweden
1 shared publicationM Wickman
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
1 shared publication
Latest Publications
- Open Access
- 1 December 2004
- Published by BMJ in Journal of Medical Genetics
- Vol. 41 (12) , e123
Sex specific protective effects of interleukin-9 receptor haplotypes on childhood wheezing and sensitisation
The interleukin-9 receptor gene (IL9R), located on the pseudoautosomal region of X and Y chromosomes (Xq28 and Yq126, 7), has previously been associated with asthma in two separate family based data sets.8, 9 Haplotype analyses of polymorphic microsatellite markers in one of the studies9 revealed significant associations, predominantly in females, which suggest that the influence may be sex specific. However, to our knowledge no study on associations between IL9R single nucleotide polymorphisms (SNPs) and asthma and allergy has yet been reported.
- 1 December 2004
- Published by BMJ in Journal of Medical Genetics
- Vol. 41 (12) , e123
Open AccessSex specific protective effects of interleukin-9 receptor haplotypes on childhood wheezing and sensitisation
The interleukin-9 receptor gene (IL9R), located on the pseudoautosomal region of X and Y chromosomes (Xq28 and Yq126, 7), has previously been associated with asthma in two separate family based data sets.8, 9 Haplotype analyses of polymorphic microsatellite markers in one of the studies9 revealed significant associations, predominantly in females, which suggest that the influence may be sex specific. However, to our knowledge no study on associations between IL9R single nucleotide polymorphisms (SNPs) and asthma and allergy has yet been reported.
- 14 June 2004
- Published by Wiley in Clinical & Experimental Allergy
- Vol. 34 (6) , 839-844
Influence of male sex and parental allergic disease on childhood wheezing: role of interactions
Summary: Background Boys have been reported to be more susceptible to childhood wheezing, whereas girls are more susceptible later in life. This difference might be related to both genetic and environmental factors.Objective To investigate the influence of male sex and parental allergic disease on the development of childhood wheezing.Methods Infants (n=4089) born in Stockholm were recruited in a prospective study, BAMSE. Data on parental allergic diseases were obtained from questionnaires answered at the children's birth and on symptoms of wheezing at 1, 2 and 4 years of age. Sensitization to inhalant allergens and lung function was investigated at the age of 4 years.Results Children were classified as having recurrent, transient (n=266), early‐onset persistent (n=319) and late‐onset wheezing (n=195). Boys were over‐represented in all groups of wheezing (odds ratio, OR=1.4–1.5) and both maternal and paternal allergic disease was of importance for the wheezing outcomes. A dominating influence from maternal allergic disease was only seen in children with persistent wheezing. An interaction exceeding additivity was found between male sex and parental allergic disease, particularly in children with persistent wheezing (OR=2.9 and 95% confidence interval, CI 95% 2.1–4.0 for boys with any parental history vs. OR=1.4, CI 95% 1.0–2.1 for girls). Interaction between male sex and parental allergic disease was also observed in children who wheezed at the age of 4 years and were sensitized to inhalant allergens.Conclusion Our data suggest an interaction between male sex and parental allergic disease in childhood wheezing, which may represent a sex‐specific genetic influence.
- 14 June 2004
- Published by Wiley in Clinical & Experimental Allergy
- Vol. 34 (6) , 839-844
Influence of male sex and parental allergic disease on childhood wheezing: role of interactions
Summary: Background Boys have been reported to be more susceptible to childhood wheezing, whereas girls are more susceptible later in life. This difference might be related to both genetic and environmental factors.Objective To investigate the influence of male sex and parental allergic disease on the development of childhood wheezing.Methods Infants (n=4089) born in Stockholm were recruited in a prospective study, BAMSE. Data on parental allergic diseases were obtained from questionnaires answered at the children's birth and on symptoms of wheezing at 1, 2 and 4 years of age. Sensitization to inhalant allergens and lung function was investigated at the age of 4 years.Results Children were classified as having recurrent, transient (n=266), early‐onset persistent (n=319) and late‐onset wheezing (n=195). Boys were over‐represented in all groups of wheezing (odds ratio, OR=1.4–1.5) and both maternal and paternal allergic disease was of importance for the wheezing outcomes. A dominating influence from maternal allergic disease was only seen in children with persistent wheezing. An interaction exceeding additivity was found between male sex and parental allergic disease, particularly in children with persistent wheezing (OR=2.9 and 95% confidence interval, CI 95% 2.1–4.0 for boys with any parental history vs. OR=1.4, CI 95% 1.0–2.1 for girls). Interaction between male sex and parental allergic disease was also observed in children who wheezed at the age of 4 years and were sensitized to inhalant allergens.Conclusion Our data suggest an interaction between male sex and parental allergic disease in childhood wheezing, which may represent a sex‐specific genetic influence.