Allan Geliebter

Objective: The extent to which different types of breakfasts affect appetite and food intake is unclear. To assess the satiety effects of a high-fiber cereal, we compared oatmeal, isocaloric corn flakes, and water. Subjects/Methods: Thirty-six subjects (18 lean, 18 overweight) were assigned to three conditions in a randomized sequence on different days. Ratings of hunger and fullness were obtained concurrently with blood samples for measuring concentrations of glucose, insulin, glucagon, leptin, and acetaminophen (gastric emptying tracer). Appetite was assessed by calculating the area under the curve (AUC) for fullness and hunger, and by measuring food intake of an ad libitum lunch meal at 180 min. Results: Lunch meal intake was lowest after consuming oatmeal (p < 0.00001), which was lower for overweight subjects than lean subjects (p = 0.007). Fullness AUC was greatest (p = 0.00001), and hunger AUC lowest (p < 0.001) after consuming oatmeal. At 180 min, blood glucose was lowest after the corn flakes (p = 0.0001). Insulin AUC was greater for both cereals than water (p < 0.00001). Leptin AUC and glucagon AUC values did not differ between conditions. Acetaminophen concentrations peaked latest after consuming oatmeal (p = 0.046), reflecting slower gastric emptying. Conclusions: Satiety was greater and ad libitum test meal intake lower after consuming oatmeal than after corn flakes, especially in the overweight subjects.

Night eating syndrome (NES) has recently been getting more attention as a recognized eating disorder. NES is characterized by a delay in the circadian pattern of food intake, associated with morning anorexia, evening hyperphagia, awakenings from sleep with ingestion of food, depressed mood, and obesity. Although the behavioral characteristics of NES were first described in 1955, the neuroendocrine characteristics have only been described recently. Researchers have examined several hormones that appear to differ in night eaters compared to controls, including melatonin, leptin, and cortisol. Researchers have more recently examined the hypothalamic-pituitary-adrenal axis in more detail, with emphasis on corticotrophin releasing hormone. Further studies have examined ghrelin, growth hormone, prolactin, and IGF-1, with differences observed in the circadian pattern of these hormones in those with NES compared to controls. Despite increasing interest in the neuroendocrine profile of night eating behavior, the biological basis of NES is still not well understood.

Objective: To assess the effects of a 50% discount on low‐energy density (ED) fruits and vegetables (F&V), bottled water, and diet sodas on shoppers' purchasing, food intake, and body weight.Design and Methods: A randomized, controlled trial was conducted at two Manhattan supermarkets, in which a 4‐week baseline period (no discounts) preceded an 8‐week intervention period (50% discount), and a 4‐week follow‐up period (no discounts). Twenty‐four hour dietary recall, as well as body weight and body composition measures were obtained every 4 weeks. Participants (n = 47, 33f; 14m) were overweight and obese (BMI ≥ 25) shoppers.Results: Purchasing of F&V during intervention was greater in the discount group than in the control group (P < 0.0001). Purchasing of these items by the discount group relative to the control group during follow‐up was reduced from intervention (P = 0.002), but still remained higher than during baseline (P = 0.01), indicating a partially sustained effect. Intake of F&V increased from baseline to intervention in the discount group relative to the control group (P = 0.037) and was sustained during follow‐up. Body weight change did not differ significantly between groups, although post hoc analysis indicated a change within the discount group (−1.1 kg, P = 0.006) but not within the control group.Conclusions: Discounts of low‐ED F&V led to increased purchasing and intake of those foods.

Objective: To explore appetite-related hormones following stress in overweight individuals, and their relationship with night eating (NE) status. Method: We measured plasma cortisol and ghrelin concentrations, and recorded ratings of stress and hunger in response to a physiological laboratory stressor (cold pressor test, CPT), in overweight women with (n=11; NE) and without (n=17; non-NE) NE. Results: Following the CPT, cortisol (PPPPP=0.019), but not when controlling for baseline cortisol levels. Ghrelin baseline and AUC did not differ between groups. NE showed higher AUC stress (P<0.05), even when controlling for baseline stress. Discussion: Overweight individuals showed increased cortisol, ghrelin, stress and hunger following a laboratory stressor, and there was some evidence for greater increases in cortisol and subjective stress among NE. The greater AUC cortisol level in NE was due to higher baseline levels, but the group difference in stress was in direct response to the stressor. Our results support a role for cortisol and stress in NE.