Alvin T. Yeh
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Alvin T. Yeh has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
Bruce J. Tromberg
2 shared publicationsJ. Stuart Nelson
University of California, Beckman Laser Institute, Laser Microbeam and Medical Program, 1002 Health Sciences Road East, Irvine, California 92612
2 shared publications- Aikaterini Zoumi
Institute of Electronic Structure and Laser Foundation for Research and Technology‐Hellas (IESL‐FORTH) Heraklion Greece
1 shared publication - Bernard Choi
University of California – Irvine, Beckman Laser Institute and Medical Clinic, Irvine, California, United States
1 shared publication - Bruce Jason Tromberg
University of California, Beckman Laser Institute and Medical Clinic, Irvine, California
1 shared publication Bunsho Kao
University of California, Beckman Laser Institute, Laser Microbeam and Medical Program, 1002 Health Sciences Road East, Irvine, California 92612
1 shared publication
Latest Publications
- Open Access
- 1 January 2004
- Published by SPIE-Intl Soc Optical Eng in Journal of Biomedical Optics
- Vol. 9 (2) , 248-253
Imaging wound healing using optical coherence tomography and multiphoton microscopy in an in vitro skin-equivalent tissue model
Laser thermal injury and subsequent wound healing in organotypic, skin-equivalent tissue models were monitored using optical coherence tomography (OCT), multiphoton microscopy (MPM), and histopathology. The in vitro skin-equivalent raft tissue model was composed of dermis with type I collagen and fibroblast cells and epidermis of differentiated keratinocytes. Noninvasive optical imaging techniques were used for time-dependent, serial measurements of matrix destruction and reconstruction and compared with histopathology. The region of laser thermal injury was clearly delineated in OCT images by low signal intensity. High resolution MPM imaging using second-harmonic generation revealed alterations in collagen microstructure organization with subsequent matrix reconstruction. Fibroblast cell migration in response to injury was monitored by MPM using two-photon excited fluorescence. This study illustrates the complementary features of linear and nonlinear light–tissue interaction in intrinsic signal optical imaging and their use for noninvasive, serial monitoring of wound healing processes in biological tissues. © 2004 Society of Photo-Optical Instrumentation Engineers.
- 1 January 2004
- Published by SPIE-Intl Soc Optical Eng in Journal of Biomedical Optics
- Vol. 9 (2) , 248-253
Open AccessImaging wound healing using optical coherence tomography and multiphoton microscopy in an in vitro skin-equivalent tissue model
Laser thermal injury and subsequent wound healing in organotypic, skin-equivalent tissue models were monitored using optical coherence tomography (OCT), multiphoton microscopy (MPM), and histopathology. The in vitro skin-equivalent raft tissue model was composed of dermis with type I collagen and fibroblast cells and epidermis of differentiated keratinocytes. Noninvasive optical imaging techniques were used for time-dependent, serial measurements of matrix destruction and reconstruction and compared with histopathology. The region of laser thermal injury was clearly delineated in OCT images by low signal intensity. High resolution MPM imaging using second-harmonic generation revealed alterations in collagen microstructure organization with subsequent matrix reconstruction. Fibroblast cell migration in response to injury was monitored by MPM using two-photon excited fluorescence. This study illustrates the complementary features of linear and nonlinear light–tissue interaction in intrinsic signal optical imaging and their use for noninvasive, serial monitoring of wound healing processes in biological tissues. © 2004 Society of Photo-Optical Instrumentation Engineers.
- 1 December 2003
- Published by Elsevier in Journal of Investigative Dermatology
- Vol. 121 (6) , 1332-1335
Reversible Dissociation of Collagen in Tissues
- 1 December 2003
- Published by Elsevier in Journal of Investigative Dermatology
- Vol. 121 (6) , 1332-1335
Reversible Dissociation of Collagen in Tissues
- 1 January 2002
- Published by Optica Publishing Group
- p. ME6
Selective corneal imaging with multiphoton microscopy
Image forming signal properties in multiphoton microscopy are used for selective visualization of corneal tissue. Spectral filtering separates cellular from extracellular components. Images of the stroma are dependent on the polarization of the incident light.
- 1 January 2002
- Published by Optica Publishing Group
- p. ME6
Selective corneal imaging with multiphoton microscopy
Image forming signal properties in multiphoton microscopy are used for selective visualization of corneal tissue. Spectral filtering separates cellular from extracellular components. Images of the stroma are dependent on the polarization of the incident light.