Joshua Schaefferkoetter
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Joshua Schaefferkoetter has a total of 3 co-authors. Here are the top co-authors by number of shared publications:
David Townsend
A*STAR-NUS Clinical Imaging Research Centre, Singapore, 117599
1 shared publication- Georges El Fakhri
Center for Advanced Radiological Sciences, Nuclear Medicine and Molecular Imaging, Radiology Department, Massachusetts General Hospital, Boston, Massachusetts
1 shared publication Michael Casey
Siemens Medical Solutions, 810 Innovation Drive, Knoxville, TN, 37919
1 shared publication
Latest Publications
- 13 February 2013
- Published by IOP Publishing in Physics in Medicine & Biology
- Vol. 58 (5) , 1465-1478
Clinical impact of time-of-flight and point response modeling in PET reconstructions: a lesion detection study
Time-of-flight (TOF) and point spread function (PSF) modeling have been shown to improve PET reconstructions, but the impact on physicians in the clinical setting has not been thoroughly investigated. A lesion detection and localization study was performed using simulated lesions in real patient images. Four reconstruction schemes were considered: ordinary Poisson OSEM (OP) alone and combined with TOF, PSF, and TOF + PSF. The images were presented to physicians experienced in reading PET images, and the performance of each was quantified using localization receiver operating characteristic. Numerical observers (non-prewhitening and Hotelling) were used to identify optimal reconstruction parameters, and observer SNR was compared to the performance of the physicians. The numerical models showed good agreement with human performance, and best performance was achieved by both when using TOF + PSF. These findings suggest a large potential benefit of TOF + PSF for oncology PET studies, especially in the detection of small, low-intensity, focal disease in larger patients.
- 13 February 2013
- Published by IOP Publishing in Physics in Medicine & Biology
- Vol. 58 (5) , 1465-1478
Clinical impact of time-of-flight and point response modeling in PET reconstructions: a lesion detection study
Time-of-flight (TOF) and point spread function (PSF) modeling have been shown to improve PET reconstructions, but the impact on physicians in the clinical setting has not been thoroughly investigated. A lesion detection and localization study was performed using simulated lesions in real patient images. Four reconstruction schemes were considered: ordinary Poisson OSEM (OP) alone and combined with TOF, PSF, and TOF + PSF. The images were presented to physicians experienced in reading PET images, and the performance of each was quantified using localization receiver operating characteristic. Numerical observers (non-prewhitening and Hotelling) were used to identify optimal reconstruction parameters, and observer SNR was compared to the performance of the physicians. The numerical models showed good agreement with human performance, and best performance was achieved by both when using TOF + PSF. These findings suggest a large potential benefit of TOF + PSF for oncology PET studies, especially in the detection of small, low-intensity, focal disease in larger patients.