Ning Qiu

The Princess Elizabeth Land landscape in East Antarctica was shaped by a complex process, involving the supercontinent’s breakup and convergence cycle. However, the lack of geological knowledge about the subglacial bedrock has made it challenging to understand this process. Our study aimed to investigate the structural characteristics of the subglacial bedrock in the Mount Brown region, utilizing airborne geophysical data collected from the China Antarctic Scientific Expedition in 2015–2017. We reconstructed bedrock density contrast and magnetic susceptibility models by leveraging Tikhonov regularized gravity and magnetic inversions. The deep bedrock in the inland direction exhibited different physical properties, indicating the presence of distinct basement sources. The east–west discontinuity of bedrock changed in the inland areas, suggesting the possibility of large fault structures or amalgamation belts. We also identified several normal faults in the western sedimentary basin, intersected by the southwest section of these survey lines. Furthermore, lithologic separators and sinistral strike-slip faults may exist in the northeast section, demarcating the boundary between Princess Elizabeth Land and Knox Valley. Our study provides new insights into the subglacial geological structure in this region, highlighting the violent impact of the I-A-A-S (Indo-Australo-Antarctic Suture) on the subglacial basement composition. Additionally, by identifying and describing different bedrock types, our study redefines the potential contribution of this region to the paleocontinent splicing process and East Antarctic basement remodeling.

Objective: Pancreatic adenocarcinoma (PAAD) is a common malignant tumor worldwide. S100 family (S100s) is wildly involved in regulating the occurrence, development, invasion, metastasis, apoptosis, and drug resistance of many malignant tumors. However, the expression pattern, prognostic value, and oncological role of individual S100s members in PAAD need to be elucidated.Methods: The transcriptional expression levels of S100s were analyzed through the Oncomine and GEPIA, respectively. The protein levels of S100s members in PAAD were studied by Human Protein Atlas. The correlation between S100 mRNA expression and overall survival and tumor stage in PAAD patients was studied by GEPIA. The transcriptional expression correlation and gene mutation rate of S100s members in PAAD patients were explored by cBioPortal. The co-expression networks of S100s are identified using STRING and Gene MANIA to predict their potential functions. The correlation of S100s expression and tumor-infiltrating immune cells was tested by TIMER. Pathway activity and drug target analyzed by GSCALite.Results: 13 S100s members were upregulated in PAAD tissues. 15 S100s members were associated with TP53 mutation. Expression levels of S100A3/A5/A6/A10/A11/A14/A16/B/P/Z were significantly correlated with the pathological stage. Prognosis analysis demonstrated that PAAD patients with low mRNA levels of S100A1/B/Z or high levels of S100A2/A3/A5/A10/A11/A14/A16 had a poor prognosis. Immuno-infiltration analysis showed that the mRNA levels of S100A10/A11/A14/A16 were correlated with the infiltration degree of macrophages in PAAD. Drug sensitivity analysis showed that PAAD expressing high levels of S100A2/A6/A10/A11/A13/A14/A16 maybe resistant to small molecule drugs.Conclusion: This study identifies the clinical significance and biological functions of the S100s in PAAD, which may provide novel insights for the selection of prognostic biomarkers.

Magmatism plays a key role in the process of continental margin breakup and ocean formation. Even in the extremely magma-poor Iberia and Newfoundland margin, studies of field outcrops have shown that syn-rift magmatism had participated in rifting from a very early stage and contributed directly to the rifting process. The final transition from exhumed continental mantle to the ocean formation is also triggered by the accumulation and eruption of magma [ 1]. Therefore, Atlantic-type passive continental margins are classified into two end-members: magma-poor (non-volcanic) and magma-rich (volcanic). The differences between them lie in whether a large amount of intrusive and extrusive magmatism from the mantle plume/hotspot is involved in the syn-rift and breakup stages. A magma-rich margin [ 2] should include the following characteristics: (i) a high-velocity lower crust (HVLC) caused by syn-rift mafic magma underplating; (ii) continental crust intruded by abundant sills and dikes; (iii) a large volume of seaward-dipping reflectors (SDRs) caused by flood basalt eruption or tuffs. All other margins are classified as magma-poor margins.