Alessandra Ghio
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Alessandra Ghio has a total of 18 co-authors. Here are the top co-authors by number of shared publications:
Graziano Di Cianni
Department of Diabetes and Metabolic Diseases, Livorno Hospital, 57100 Livorno, Italy
3 shared publicationsAlessandra Bertolotto
Section of Metabolic Diseases and Diabetes, Department of Endocrinology and Metabolism, AOUP Pisa, University of Pisa, Ospedale Cisanello, Via Paradisa, 56124 Pisa, Italy
2 shared publicationsCristina Lencioni
Department of Diabetes and Metabolic Diseases, Livorno Hospital, 57100 Livorno, Italy
2 shared publications- Laura Volpe
Laura Volpe, Department of Endocrinology & Metabolism, Section of Metabolic Diseases & Diabetes AOUP Pisa, University of Pisa, Ospedale Cisanello, Via Paradisa 2, 56124 Pisa, Italy, Tel.: +39 050 995 133, Fax: +39 050 541 521
2 shared publications - Stefano Del Prato
Interdisciplinary Research Center ‘Health Science’, Sant’Anna School of Advanced Studies, Pisa, Italy
2 shared publications Veronica Resi
Section of Metabolic Diseases and Diabetes, Department of Endocrinology and Metabolism, AOUP Pisa, University of Pisa, Ospedale Cisanello, Via Paradisa, 56124 Pisa, Italy
2 shared publications
Latest Publications
- Open Access
- 10 April 2012
- Published by Hindawi Limited in International Journal of Endocrinology
- Vol. 2012, 1-5
1-Hour OGTT Plasma Glucose as a Marker of Progressive Deterioration of Insulin Secretion and Action in Pregnant Women
Considering old GDM diagnostic criteria, alterations in insulin secretion and action are present in women with GDM as well as in women with one abnormal value (OAV) during OGTT. Our aim is to assess if changes in insulin action and secretion during pregnancy are related to 1-hour plasma glucose concentration during OGTT. We evaluated 3 h/100 g OGTT in 4,053 pregnant women, dividing our population on the basis of 20 mg/dL increment of plasma glucose concentration at 1 h OGTT generating 5 groups (<120 mg/dL,; 120–139 mg/dL,; 140–159 mg/dL,; 160–179 mg/dL,; and ≥180 mg/dL,). We calculated incremental area under glucose (AUCgluc) and insulin curves (AUCins), indexes of insulin secretion (HOMA-B), and insulin sensitivity (HOMA-R), AUCins/AUCgluc. AUCglucand AUCinsprogressively increased according to 1-hour plasma glucose concentrations (bothfor trend). HOMA-B progressively declined (), and HOMA-R progressively increased across the five groups. AUCins/AUCglucdecreased in a linear manner across the 5 groups (). Analysing the groups with 1-hour value <180 mg/dL, defects in insulin secretion (HOMA-B: −29.7%) and sensitivity (HOMA-R: +15%) indexes were still apparent (all). Progressive increase in 1-hour OGTT is associated with deterioration of glucose tolerance and alterations in indexes of insulin action and secretion.- 10 April 2012
- Published by Hindawi Limited in International Journal of Endocrinology
- Vol. 2012, 1-5
Open Access1-Hour OGTT Plasma Glucose as a Marker of Progressive Deterioration of Insulin Secretion and Action in Pregnant Women
Considering old GDM diagnostic criteria, alterations in insulin secretion and action are present in women with GDM as well as in women with one abnormal value (OAV) during OGTT. Our aim is to assess if changes in insulin action and secretion during pregnancy are related to 1-hour plasma glucose concentration during OGTT. We evaluated 3 h/100 g OGTT in 4,053 pregnant women, dividing our population on the basis of 20 mg/dL increment of plasma glucose concentration at 1 h OGTT generating 5 groups (<120 mg/dL,; 120–139 mg/dL,; 140–159 mg/dL,; 160–179 mg/dL,; and ≥180 mg/dL,). We calculated incremental area under glucose (AUCgluc) and insulin curves (AUCins), indexes of insulin secretion (HOMA-B), and insulin sensitivity (HOMA-R), AUCins/AUCgluc. AUCglucand AUCinsprogressively increased according to 1-hour plasma glucose concentrations (bothfor trend). HOMA-B progressively declined (), and HOMA-R progressively increased across the five groups. AUCins/AUCglucdecreased in a linear manner across the 5 groups (). Analysing the groups with 1-hour value <180 mg/dL, defects in insulin secretion (HOMA-B: −29.7%) and sensitivity (HOMA-R: +15%) indexes were still apparent (all). Progressive increase in 1-hour OGTT is associated with deterioration of glucose tolerance and alterations in indexes of insulin action and secretion. - Open Access
- 1 January 2010
- Published by SAGE Publications in Women's Health
- Vol. 6 (1) , 97-105
Gestational Diabetes Mellitus: An Opportunity to Prevent Type 2 Diabetes and Cardiovascular Disease in Young Women
In women with previous gestational diabetes (pGDM), the risk of developing Type 2 diabetes is greatly increased, to the point that GDM represents an early stage in the natural history of Type 2 diabetes. In addition, in the years following the index pregnancy, women with pGDM exhibit an increased cardiovascular risk profile and an increased incidence of cardiovascular disease. This paper will review current knowledge on the metabolic modifications that occur in normal pregnancy, underlining the mechanism responsible for GDM, the link between these alterations and the associated long-term maternal complications. In women with pGDM, accurate follow-up and prevention strategies (e.g., weight control and regular physical exercise) are needed to reduce the subsequent development of overt diabetes and other metabolic abnormalities related to cardiovascular disease. Therefore, our paper will provide arguments in favor of performing follow-up programs aimed at modifying risk factors involved in the pathogenesis of Type 2 diabetes and cardiovascular disease.
- 1 January 2010
- Published by SAGE Publications in Women's Health
- Vol. 6 (1) , 97-105
Open AccessGestational Diabetes Mellitus: An Opportunity to Prevent Type 2 Diabetes and Cardiovascular Disease in Young Women
In women with previous gestational diabetes (pGDM), the risk of developing Type 2 diabetes is greatly increased, to the point that GDM represents an early stage in the natural history of Type 2 diabetes. In addition, in the years following the index pregnancy, women with pGDM exhibit an increased cardiovascular risk profile and an increased incidence of cardiovascular disease. This paper will review current knowledge on the metabolic modifications that occur in normal pregnancy, underlining the mechanism responsible for GDM, the link between these alterations and the associated long-term maternal complications. In women with pGDM, accurate follow-up and prevention strategies (e.g., weight control and regular physical exercise) are needed to reduce the subsequent development of overt diabetes and other metabolic abnormalities related to cardiovascular disease. Therefore, our paper will provide arguments in favor of performing follow-up programs aimed at modifying risk factors involved in the pathogenesis of Type 2 diabetes and cardiovascular disease.
- 31 October 2006
- Published by Elsevier in Nutrition, Metabolism and Cardiovascular Diseases
- Vol. 16 (7) , 485-493
Early impairment of β-cell function and insulin sensitivity characterizes normotolerant Caucasian women with previous gestational diabetes
- 31 October 2006
- Published by Elsevier in Nutrition, Metabolism and Cardiovascular Diseases
- Vol. 16 (7) , 485-493
Early impairment of β-cell function and insulin sensitivity characterizes normotolerant Caucasian women with previous gestational diabetes