Christopher Sheridan
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Christopher Sheridan has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Bruna Silva
Departamento de Biologia & CESAM, Universidade de Aveiro, Campus Universitário de Santiago, Aveiro 3810-193, Portugal
1 shared publication - Gisela Dionísio
Laboratório Marítimo da Guia, Centro de Oceanografia, Faculdade de Ciências da Universidade de Lisboa, Av. Nossa Senhora do Cabo, 939, 2750-374 Cascais, Portugal
1 shared publication - Miguel Costa Leal
Centre for Environmental and Marine Studies, University of Aveiro 8 , Aveiro 3810-193, Portugal
1 shared publication - Ricardo Calado
ECOMARE, CESAM—Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, Santiago University Campus, 3810-193 Aveiro, Portugal
1 shared publication - Ronald Osinga
Wageningen University & Research
1 shared publication - Rui Jorge Miranda Rocha
CESAM—Centre for Environmental and Marine Studies and Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal
1 shared publication
Latest Publications
- Open Access
- 30 June 2014
- Published by MDPI AG in Marine Drugs
- Vol. 12 (7) , 3929-3952
Marine Microorganism-Invertebrate Assemblages: Perspectives to Solve the “Supply Problem” in the Initial Steps of Drug Discovery
The chemical diversity associated with marine natural products (MNP) is unanimously acknowledged as the “blue gold” in the urgent quest for new drugs. Consequently, a significant increase in the discovery of MNP published in the literature has been observed in the past decades, particularly from marine invertebrates. However, it remains unclear whether target metabolites originate from the marine invertebrates themselves or from their microbial symbionts. This issue underlines critical challenges associated with the lack of biomass required to supply the early stages of the drug discovery pipeline. The present review discusses potential solutions for such challenges, with particular emphasis on innovative approaches to culture invertebrate holobionts (microorganism-invertebrate assemblages) through in toto aquaculture, together with methods for the discovery and initial production of bioactive compounds from these microbial symbionts.
- 30 June 2014
- Published by MDPI AG in Marine Drugs
- Vol. 12 (7) , 3929-3952
Open AccessMarine Microorganism-Invertebrate Assemblages: Perspectives to Solve the “Supply Problem” in the Initial Steps of Drug Discovery
The chemical diversity associated with marine natural products (MNP) is unanimously acknowledged as the “blue gold” in the urgent quest for new drugs. Consequently, a significant increase in the discovery of MNP published in the literature has been observed in the past decades, particularly from marine invertebrates. However, it remains unclear whether target metabolites originate from the marine invertebrates themselves or from their microbial symbionts. This issue underlines critical challenges associated with the lack of biomass required to supply the early stages of the drug discovery pipeline. The present review discusses potential solutions for such challenges, with particular emphasis on innovative approaches to culture invertebrate holobionts (microorganism-invertebrate assemblages) through in toto aquaculture, together with methods for the discovery and initial production of bioactive compounds from these microbial symbionts.