Agnes van Minnen

Anorexia nervosa (AN) and Obsessive Compulsive Disorder (OCD) are among the most incapacitating and costly of mental disorders. Cognitive Behaviour Therapy (CBT), medication, and combination regimens, to which in AN personalised guidance on weight control is added, are moderately successful, leaving room for more effective treatment algorithms. An underlying deficit which the two disorders share is cognitive inflexibility, a trait that is likely to impede treatment engagement and reduce patients’ ability to benefit from treatment. Cognitive remediation therapy (CRT) is an easy-to-use intervention aimed at reducing cognitive inflexibility and thereby enhancing treatment outcome, which we aim to test in a controled study. In a randomized-controlled multicenter clinical trial 64 adult patients with AN and 64 with OCD are randomized to 10 bi-weekly sessions with either CRT or a control condition, after which Treatment As Usual (TAU) is started. All patients are evaluated during single-blind assessments at baseline, post-CRT/control intervention, and after 6 months. Indices of treatment effect are disorder-specific symptom severity, quality of life, and cost-effectivity. Also, moderators and mediators of treatment effects will be studied. To our knowledge, this is the first randomized controlled trial using an control condition evaluating the efficacy and effectiveness of CRT as a treatment enhancer preceding TAU for AN, and the first study to investigate CRT in OCD, moreover taking cost-effectiveness of CRT in AN and OCD into account. The Netherlands Trial Register NTR3865 . Registered 20 february 2013.

Summary: This study presents secondary analyses of a recently published trial in which post-traumatic stress disorder (PTSD) patients with psychosis (n = 108) underwent 8 sessions of trauma-focused treatment, either prolonged exposure (PE) or eye movement desensitisation and reprocessing (EMDR) therapy. 24.1% fulfilled the criteria for the dissociative subtype, a newly introduced PTSD subtype in DSM-5. Treatment outcome was compared for patients with and without the dissociative subtype of PTSD. Patients with the dissociative subtype of PTSD showed large reductions in clinician-administered PTSD scale (CAPS) score, comparable with patients without the dissociative subtype of PTSD. It is concluded that even in a population with severe mental illness, patients with the dissociative subtype of PTSD do benefit from trauma-focused treatments without a pre-phase of emotion regulation skill training and should not be excluded from these treatments.

Although research has shown exposure therapy to have earned its rank among empirically supported treatments (ESTs) for anxiety disorders, several US-based studies suggest it to be underused in clinical practice. Data on exposure use in Europe is mainly lacking, whereas its state of dissemination in countries such as the Netherlands has remained uncharted. Therefore, this study examined the use of exposure therapy among members of the Dutch Association for Behavioural and Cognitive Therapy (VGCt), as well as explored therapist, educational and contextual variables that could facilitate its dissemination in clinical practice. Respondents (n = 490) were surveyed on clinical interventions used in their treatment for social anxiety disorder, phobia, OCD and panic disorder. Data was collected on the use of (disorder) specific interventions, therapists’ attitudes on exposure, treatment experience, current educational status, educational background and workplace characteristics. Analysis of the data showed that most therapists implemented exposure frequently, but that exposure use still warrants improvement, specifically for certain (disorder-specific) interventions that were accordingly underused. Confirming our hypothesis, we found that clinicians who practiced exposure regularly also reported a greater willingness to use the treatment, perceived the method as more credible, and saw fewer barriers for its usage than those who did so less. The use of (disorder-) specific interventions, such as in vivo exposure (therapist as well as self-directed), exposure and response prevention for OCD, and interoceptive exposure for panic disorder, was positively related to level of education. While most were satisfied with the training they had received, therapists did report a need for additional instruction in targeted practical, empirical, and diagnostic skills. Our findings support the conclusion that the dissemination of exposure therapy in the Netherlands progresses well, but that education in certain (disorder-specific) techniques merits augmentation. To bridge the gap between research and clinical practice, future research should therefore focus on new, preferably blended approaches to training clinicians in exposure techniques.

Prolonged exposure (PE) is an effective psychological treatment for patients who suffer from PTSD. The majority of PTSD patients have comorbid psychiatric disorders, and some clinicians are hesitant to use PE with comorbid patients because they believe that comorbid conditions may worsen during PE. In this article, we reviewed the evidence for this question: what are the effects of PE on comorbid symptoms and associated symptomatic features? We reviewed findings from 18 randomized controlled trials of PE that assessed the most common comorbid conditions (major depression, anxiety disorders, substance use disorders, personality disorders, and psychotic disorders) and additional symptomatic features (suicidality, dissociation, negative cognitions, negative emotions, and general health and work/social functioning). Although systematic research is not available for all comorbid populations, the existing research indicates that comorbid disorders and additional symptomatic features either decline along with the PTSD symptoms or do not change as a result of PE. Therefore, among the populations that have been studied to date, there is no empirical basis for excluding PTSD patients from PE due to fear of increases in comorbid conditions or additional symptomatic features. Limitations of the existing research and recommendations for future research are also discussed.

Implicit and explicit avoidance in sexual trauma victims suffering from posttraumatic stress disorder: a pilot study