Muzaffer Kanlikama

Oral cavity,oropharynx,neoplasms,human papillomavirus p16,immunohistochemistry

Background/Aim: Larynx cancers account for 2-5% of all malignancies worldwide. With early diagnosis, radiotherapy or a partial laryngectomy may help preserve voice and laryngeal functions and reduce morbidity. This study aimed to evaluate how laryngeal functions, voice, and life quality were affected in larynx cancer patients after partial and extended partial laryngectomy. Methods: The patients who were diagnosed with larynx cancer and underwent partial (supraglottic laryngectomy (SGL), supracricoid laryngectomy (SCL)) or extended partial laryngectomy (extended supraglottic laryngectomy (ESGL) and extended supracricoid laryngectomy (ESCL)) between May 2010 and December 2015 in the otorhinolaryngology clinic of a Training and Research Hospital were included in this study. A questionnaire comprising three forms was filled in by these patients. Voice quality, duration of hospitalization, time until removal of the nasogastric tube, location of the tumor, time of decannulation, swallowing, and cough were compared with regards to the types of laryngectomies. Results: Our study began with 102 patients who had a partial laryngectomy; however, twelve who eventually had to undergo a total laryngectomy were excluded. Of the remaining 90 patients, 67 filled out our questionnaire. Functional score (FS), social functional score (SFS), symptom score (SS), fatigue score (FAS), general health score (GHS), and swallowing symptoms score (HNSW) were calculated and compared. These scores did not differ with the types of laryngectomies. In terms of voice quality, there were significant differences between ESCL-SGL, SCL-SGL, ESGL-SGL groups (P=0.001, P=0.004, and P=0.004, respectively). Conclusion: Despite numerous changes in swallowing physiology and larynx anatomy after partial and extended partial laryngectomy, swallowing function is restored, and the patients can lead a healthy life. '+st+' Kaya S. Larenks Hastalıkları. Ankara: Bilimsel Tıp Yay; Ocak 2002;539–716. Özlügedik S, Ünal A. Bas boyun kanserlerinde epidemiyoloji ve risk faktörleri. KBB Bas Boyun Cerrahisi’nde Güncel Yaklaşım. 2005;1:51–6. Testa MA, Simonson DC. Assessment of quality-of-life outcomes. N Engl J Med. 1996 Mar 28;334(13):835-40. doi: 10.1056/NEJM199603283341306. PMID: 8596551. QL Coordinator Quality of Life Unit, EORTC Data Center, Avenue E. Mounier 83 - B11, 1200 Brussels, Belgium, Email: abo@eortc.be Long SA, D'Antonio LL, Robinson EB, Zimmerman G, Petti G, Chonkich G. Factors related to quality of life and functional status in 50 patients with head and neck cancer. Laryngoscope. 1996 Sep;106(9 Pt 1):1084-8. doi: 10.1097/00005537-199609000-00008. PMID: 8822710. 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Purpose The incidence of Warthin’s tumor (WT) has increased worldwide. In this study, we aimed to evaluate the incidence of WT in our hospital, which provides health care for an extremely large population. Methods We retrospectively evaluated 573 patients, comprising 345 males and 228 females, who all experienced parotid tumor for the past 20 years. Patients with WT that were operated in the last 20 years were evaluated according to the number of patients per year to determine the annual WT increase trend. Results In the distribution of WT over the years of surgery, the ratio of WT to all tumors irregularly changed. Furthermore, the total number of parotidectomies per year increased in time. We investigated whether WT had any increasing trend over the years. The annual percentage change (APC) of WT was calculated, and according to the segmented regression analysis, the APC was insignificant (APC = 4.3, 95% CI = − 3.6–12.9, P = 0.300). Conclusion The incidence of WT has increased across the world. However, in our study, no significant APC was observed according to the segmented regression analysis.

In this study the authors evaluated the outcomes of tracheal resection and anastomosis in postintubation tracheal stenosis. The authors also aimed to identify clinical and radiological factors associated with restenosis. Thirty-four consecutive patients were included in the study. Patients with subglottic stenosis who underwent procedures involving cricoid cartilage and patients with other etiologies were excluded from the study. Univariate analysis was performed to determine the risk factors for restenosis. Receiver operating characteristic (ROC) curves were generated for the diameter of the narrowest part of the trachea (Dst) and the distance between cricoid cartilage and stenosis (Dcs). Of the 34 patients, 31 (91.1%) patients were successfully decannulated. Nineteen (55.8%) patients had complications. After univariate analysis, Dst (P = 0.001), Dcs (P = 0.001), smoking (P = 0.007) and grade of the stenosis (P = 0.003) were significantly associated with restenosis. The sensitivity and specificity were 90.9% and 77.3%, respectively, when the cutoff value for Dst was 4 mm. Sensitivity and specificity were 72.7% and 100%, respectively, when the cutoff value for Dcs was 10 mm. Tracheal resection and anastomosis is an effective surgical method for treating postintubation tracheal stenosis. In our series, 91.1% of the patients with postintubation tracheal stenosis were successfully decannulated. Restenosis was the most common complication. The diameter of the narrowest part of the trachea (Dst), the distance between cricoid cartilage and stenosis (Dcs), smoking and grade of stenosis were significantly associated with restenosis.

Objective: To evaluate the auditory functions and progress of speech development in children with and without cochlear anomalies who underwent cochlear implantation due to prelingual profound sensorineural hearing loss (SNHL).Methods: This study was conducted at Gaziantep University Faculty of Medicine Ear-Nose-Throat Department, between October 2006 and December 2007. A total of 69 children (aged 6 to 24 months) diagnosed with profound SNHL were included. Patients were divided into two groups with respect to the presence of inner ear anomalies: Group-1 consisted of 41 children without inner ear anomaly, whereas Group-2 was composed of 28 patients with inner ear anomalies. The auditory performance was assessed using Listening Progress Profile Test (LPPT) and Monosyllabic Trochee Polysyllabic Test (MTP), the subsections of Evaluation of Auditory Responses to Speech (EARS) test battery.Results: Preoperative LPPT scores were 5 (12%) in both groups. Mean LPPT values after fitting in Group-1 and Group-2 on 1st, 3rd and 6th months were 18.5 (44.1%) and 19 (45.6%); 27 (64.2%) and 28 (67.3%); 31 (75%) and 34 (83%), respectively. Postoperatively, MTP scores in Group-1 and Group-2 were 7.5 (62%) and 7.7 (64%) for 3-words set; 10.4 (58%) and 10.6 (59%) for 6-words set; 14.3 (60%) and 14 (59%) for 12-words set, respectively. The rate of stimulation for electrodes was 1345 q/u (quick/unit) in Group-1 and 1310 q/u in Group-2. No statistically significant difference was detected between groups for variables under investigation.Conclusion: Cochlear implantation is an effective treatment in children with prelingual profound SNHL. Auditory performance and advancement of speech are similar for children with and without inner ear anomalies.doi: https://doi.org/10.12669/pjms.342.14066How to cite this:Celik M, Karatas E, Kanlikama M. Outcomes of cochlear implantation in children with and without inner ear malformations. Pak J Med Sci. 2018;34(2):380-384.

Congenital choanal atresia (CCA) is a very rare abnormality of the nose, but in the case of bilateral presence, it becomes a life-threatening malformation. Various surgical treatment options, such as transpalatal, transseptal, and open rhinoplasty techniques, as well as the transnasal approach, have been defined for the repair of CCA. In this study, the authors intended to evaluate the outcomes of transnasal endoscopic surgery for CCA, and stent implementation's impact on surgical success. Patients who were admitted to the Otorhinolaryngology Department of Gaziantep University and patients who had not undergone CCA surgery before were included in the study. Patients who underwent transnasal endoscopic choanal atresia surgery (TECAS) were advised to have regular nasal endoscopic examinations performed at check-ups; after a 6-month follow-up period, surgical results were evaluated concerning whether stenosis had occurred or not. Of the 48 patients who underwent TECAS after a minimum 6-month follow-up period, 34 of patients revealed no stenosis, so the overall surgical success rate was 70.8%. Fourteen (29.2%) patients who underwent TECAS developed stenosis and required revision surgery. Transnasal endoscopic choanal atresia surgery is the most preferred approach for CCA repair and has many advantages, such as excellent vision, shorter operative time, minimal bleeding, and minimum complication. Despite advances in endovision systems and surgical instruments, stenosis is the most challenging problem after TECAS, so new treatment strategies should be developed to prevent stenosis.

Objective: Tinnitus is described as the perception of sound without any external acoustic stimulation. Any pathology of auditory pathways or any system of the human body may result with tinnitus. The pathophysiology of tinnitus accompanying the disorders of auditory system is not fully understood and there is not any particular effective treatment method has been specified. Tinnitus masking therapy has been reported as an effective treatment modality in the treatment of tinnitus. In this study, the results of tinnitus masking treatment on the parameters were evaluated prospectively. Patients and methods: Patients with normal physical examination was enrolled in the study. Blood tests (complete blood count, biochemical analysis of lipid profile, and thyroid hormones), pure tone audiometry, tympanometric measurement of the middle ear pressure and stapedial reflexes were performed, Sixty six patients with normal results of blood tests and normal hearing thresholds with type A tympanogram were included. Tinnitus sufferers questionnaires (socio-demographics, clinical information, Tinnitus Handicap Inventory (THI), Beck Depression Inventory (BDI) was filled, audiological tests were performed, tinnitus parameters (frequency, intensity, minimal masking levels, residual inhibition) were measured. After four weeks of the treatment the questionnaires were repeated. Results: Masking treatment for tinnitus patients resulted with significant decrease in Tinnitus Handicap Inventory and VAS scores. After four weeks of the masking treatment the questionnaire was repeated. Twenty patients did not respond to treatment. Conclusion: Masking therapy is one of the most effective methods of treatment for tinnitus patients. Masking therapy, that is not invasive and cost-effective has an important place in the treatment of tinnitus. Especially in a short time provides a significant reduction in tinnitus parameters.

ENT Updates / An International Journal of ENT and Related Subjects