Mengbi Guo
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Mengbi Guo has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Chun Guo
Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, China
1 shared publication - Hang Xu
Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China
1 shared publication - Xin Su
School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China
1 shared publication - Ye Tian
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, China
1 shared publication - Zhen Liang
Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China
1 shared publication
Latest Publications
- Open Access
Design, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids
A series of novel benzofuran-triazole hybrids was designed and synthesized by click chemistry, and their structures were characterized by HRMS, FTIR and NMR. The in vitro antifungal activity of target compounds was evaluated using the microdilution broth method against five strains of pathogenic fungi. The result indicated that the target compounds exhibited moderate to satisfactory activity. Furthermore, molecular docking was performed to investigate the binding affinities and interaction modes between the target compound and N-myristoyltransferase. Based on the results, preliminary structure activity relationships (SARs) were summarized to serve as a foundation for further investigation.
Open AccessDesign, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids
A series of novel benzofuran-triazole hybrids was designed and synthesized by click chemistry, and their structures were characterized by HRMS, FTIR and NMR. The in vitro antifungal activity of target compounds was evaluated using the microdilution broth method against five strains of pathogenic fungi. The result indicated that the target compounds exhibited moderate to satisfactory activity. Furthermore, molecular docking was performed to investigate the binding affinities and interaction modes between the target compound and N-myristoyltransferase. Based on the results, preliminary structure activity relationships (SARs) were summarized to serve as a foundation for further investigation.