Clive S. Zent
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Clive S. Zent has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
Fenghuang Zhan
1 shared publicationJames B Chen
1 shared publicationJohn D Shaughnessy
1 shared publicationKlaus H.W Bumm
1 shared publicationMouhammed J. Kyasa
Division of Hematology/Oncology, Department of Medicine, Central Arkansas Veterans Healthcare System and University of Arkansas for Medical Sciences, Little Rock, Arkansas
1 shared publicationPei Lin
1 shared publication
Latest Publications
- 1 September 2003
- Published by Elsevier in Leukemia Research
- Vol. 27 (9) , 765-774
The distinct gene expression profiles of chronic lymphocytic leukemia and multiple myeloma suggest different anti-apoptotic mechanisms but predict only some differences in phenotype
- 1 September 2003
- Published by Elsevier in Leukemia Research
- Vol. 27 (9) , 765-774
The distinct gene expression profiles of chronic lymphocytic leukemia and multiple myeloma suggest different anti-apoptotic mechanisms but predict only some differences in phenotype
- Open Access
Chronic lymphocytic leukemia incidence is substantially higher than estimated from tumor registry data
BACKGROUND Although chronic lymphocytic leukemia (CLL) often is described as the most common leukemia in the U.S. and Western Europe, to the authors' knowledge the true incidence of CLL in the U.S. is unknown. CLL incidence is estimated from tumor registry reports based on tissue pathology and cancer treatment data. Tumor registry data may underestimate the incidence of CLL substantially because CLL can be diagnosed by flow cytometric analysis of peripheral blood cells, and the majority of patients do not require treatment at the time of diagnosis. METHODS To test the hypothesis that CLL has a higher incidence than estimated from tumor registry data, the authors compared the actual and reported incidence of CLL for a 10‐year interval at the Central Arkansas Veterans Healthcare System (CAVHS). The accuracy of surveillance methods for new diagnoses of CLL was confirmed by reviewing the lymphocyte counts in 45,009 CAVHS patients over a 4‐year period. RESULTS The tumor registry correctly reported 58 of 93 patients with CLL (62.4%) who were diagnosed between January 1, 1990 and December 31, 1999. The tumor registry correctly reported 100% of patients with CLL diagnosed between 1990–1991 but reported only 34.5% of patients with CLL diagnosed between 1998–1999. CONCLUSIONS The incidence of CLL in the CAVHS was 37.6% higher than estimated from tumor registry data due to an increase in the use of peripheral blood immunophenotype as the only diagnostic test for CLL over the time period of the study. These data suggest that the true incidence of CLL may be substantially higher than estimated from tumor registry data. Cancer 2001;92:1325–30. © 2001 American Cancer Society.
Open AccessChronic lymphocytic leukemia incidence is substantially higher than estimated from tumor registry data
BACKGROUND Although chronic lymphocytic leukemia (CLL) often is described as the most common leukemia in the U.S. and Western Europe, to the authors' knowledge the true incidence of CLL in the U.S. is unknown. CLL incidence is estimated from tumor registry reports based on tissue pathology and cancer treatment data. Tumor registry data may underestimate the incidence of CLL substantially because CLL can be diagnosed by flow cytometric analysis of peripheral blood cells, and the majority of patients do not require treatment at the time of diagnosis. METHODS To test the hypothesis that CLL has a higher incidence than estimated from tumor registry data, the authors compared the actual and reported incidence of CLL for a 10‐year interval at the Central Arkansas Veterans Healthcare System (CAVHS). The accuracy of surveillance methods for new diagnoses of CLL was confirmed by reviewing the lymphocyte counts in 45,009 CAVHS patients over a 4‐year period. RESULTS The tumor registry correctly reported 58 of 93 patients with CLL (62.4%) who were diagnosed between January 1, 1990 and December 31, 1999. The tumor registry correctly reported 100% of patients with CLL diagnosed between 1990–1991 but reported only 34.5% of patients with CLL diagnosed between 1998–1999. CONCLUSIONS The incidence of CLL in the CAVHS was 37.6% higher than estimated from tumor registry data due to an increase in the use of peripheral blood immunophenotype as the only diagnostic test for CLL over the time period of the study. These data suggest that the true incidence of CLL may be substantially higher than estimated from tumor registry data. Cancer 2001;92:1325–30. © 2001 American Cancer Society.