Meyer J. Wolin
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Meyer J. Wolin has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
Gary A. Weaver
<!--label omitted: 3-->The Mary Imogene Bassett Research Institute and Department of Medicine, The Mary Imogene Bassett Hospital, Cooperstown, New York 133263
1 shared publicationShelton Bank
<!--label omitted: 2-->Department of Chemistry, State University of New York-Albany, Albany, New York 122222; and
1 shared publicationSusan Yerry
<!--label omitted: 1-->Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany, New York 12201-05091
1 shared publicationTerry L. Miller
<!--label omitted: 1-->Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany, New York 12201-05091
1 shared publicationYongchao Zhang
<!--label omitted: 2-->Department of Chemistry, State University of New York-Albany, Albany, New York 122222; and
1 shared publication
Latest Publications
- 1 July 1999
- Published by American Society for Microbiology in Applied and Environmental Microbiology
- Vol. 65 (7) , 2807-2812
Changes of Fermentation Pathways of Fecal Microbial Communities Associated with a Drug Treatment That Increases Dietary Starch in the Human Colon
Acarbose inhibits starch digestion in the human small intestine. This increases the amount of starch available for microbial fermentation to acetate, propionate, and butyrate in the colon. Relatively large amounts of butyrate are produced from starch by colonic microbes. Colonic epithelial cells use butyrate as an energy source, and butyrate causes the differentiation of colon cancer cells. In this study we investigated whether colonic fermentation pathways changed during treatment with acarbose. We examined fermentations by fecal suspensions obtained from subjects who participated in an acarbose-placebo crossover trial. After incubation with [1- 13 C]glucose and 12 CO 2 or with unlabeled glucose and 13 CO 2 , the distribution of 13 C in product C atoms was determined by nuclear magnetic resonance spectrometry and gas chromatography-mass spectrometry. Regardless of the treatment, acetate, propionate, and butyrate were produced from pyruvate formed by the Embden-Meyerhof-Parnas pathway. Considerable amounts of acetate were also formed by the reduction of CO 2 . Butyrate formation from glucose increased and propionate formation decreased with acarbose treatment. Concomitantly, the amounts of CO 2 reduced to acetate were 30% of the total acetate in untreated subjects and 17% of the total acetate in the treated subjects. The acetate, propionate, and butyrate concentrations were 57, 20, and 23% of the total final concentrations, respectively, for the untreated subjects and 57, 13, and 30% of the total final concentrations, respectively, for the treated subjects.
- 1 July 1999
- Published by American Society for Microbiology in Applied and Environmental Microbiology
- Vol. 65 (7) , 2807-2812
Changes of Fermentation Pathways of Fecal Microbial Communities Associated with a Drug Treatment That Increases Dietary Starch in the Human Colon
Acarbose inhibits starch digestion in the human small intestine. This increases the amount of starch available for microbial fermentation to acetate, propionate, and butyrate in the colon. Relatively large amounts of butyrate are produced from starch by colonic microbes. Colonic epithelial cells use butyrate as an energy source, and butyrate causes the differentiation of colon cancer cells. In this study we investigated whether colonic fermentation pathways changed during treatment with acarbose. We examined fermentations by fecal suspensions obtained from subjects who participated in an acarbose-placebo crossover trial. After incubation with [1- 13 C]glucose and 12 CO 2 or with unlabeled glucose and 13 CO 2 , the distribution of 13 C in product C atoms was determined by nuclear magnetic resonance spectrometry and gas chromatography-mass spectrometry. Regardless of the treatment, acetate, propionate, and butyrate were produced from pyruvate formed by the Embden-Meyerhof-Parnas pathway. Considerable amounts of acetate were also formed by the reduction of CO 2 . Butyrate formation from glucose increased and propionate formation decreased with acarbose treatment. Concomitantly, the amounts of CO 2 reduced to acetate were 30% of the total acetate in untreated subjects and 17% of the total acetate in the treated subjects. The acetate, propionate, and butyrate concentrations were 57, 20, and 23% of the total final concentrations, respectively, for the untreated subjects and 57, 13, and 30% of the total final concentrations, respectively, for the treated subjects.