Elaine Wong Yee-Man
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Elaine Wong Yee-Man has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
Elaine.
1 shared publicationElaine. Yee-Man Wong
1 shared publicationHaoran Zhang
School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
1 shared publicationLi Wang
School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
1 shared publication- Mai Har Sham
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
1 shared publication Pin-Xian Xu
Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, United States
1 shared publication
Latest Publications
- Open Access
- 15 November 2017
- Published by eLife Sciences Publications, Ltd in eLife
- Vol. 6
An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis
Craniofacial morphogenesis requires proper development of pharyngeal arches and epibranchial placodes. We show that the epibranchial placodes, in addition to giving rise to cranial sensory neurons, generate a novel lineage-related non-neuronal cell population for mouse pharyngeal arch development. Eya1 is essential for the development of epibranchial placodes and proximal pharyngeal arches. We identify an Eya1-Notch regulatory axis that specifies both the neuronal and non-neuronal commitment of the epibranchial placode, where Notch acts downstream of Eya1 and promotes the non-neuronal cell fate. Notch is regulated by the threonine phosphatase activity of Eya1. Eya1 dephosphorylates p-threonine-2122 of the Notch1 intracellular domain (Notch1 ICD), which increases the stability of Notch1 ICD and maintains Notch signaling activity in the non-neuronal epibranchial placodal cells. Our data unveil a more complex differentiation program in epibranchial placodes and an important role for the Eya1-Notch axis in craniofacial morphogenesis.
- 15 November 2017
- Published by eLife Sciences Publications, Ltd in eLife
- Vol. 6
Open AccessAn Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis
Craniofacial morphogenesis requires proper development of pharyngeal arches and epibranchial placodes. We show that the epibranchial placodes, in addition to giving rise to cranial sensory neurons, generate a novel lineage-related non-neuronal cell population for mouse pharyngeal arch development. Eya1 is essential for the development of epibranchial placodes and proximal pharyngeal arches. We identify an Eya1-Notch regulatory axis that specifies both the neuronal and non-neuronal commitment of the epibranchial placode, where Notch acts downstream of Eya1 and promotes the non-neuronal cell fate. Notch is regulated by the threonine phosphatase activity of Eya1. Eya1 dephosphorylates p-threonine-2122 of the Notch1 intracellular domain (Notch1 ICD), which increases the stability of Notch1 ICD and maintains Notch signaling activity in the non-neuronal epibranchial placodal cells. Our data unveil a more complex differentiation program in epibranchial placodes and an important role for the Eya1-Notch axis in craniofacial morphogenesis.
- Open Access
- 1 January 2006
- Published by The University of Hong Kong Libraries
Analysis of abnormal craniofacial and ear development of a transgenic mutant with ectopic hoxb3 expression
Published_or_final_versionBiochemistryDoctoralDoctor of Philosoph
- 1 January 2006
- Published by The University of Hong Kong Libraries
Open AccessAnalysis of abnormal craniofacial and ear development of a transgenic mutant with ectopic hoxb3 expression
Published_or_final_versionBiochemistryDoctoralDoctor of Philosoph
- Open Access
- 1 January 2002
- Published by The University of Hong Kong Libraries
Identification and characterization of VCY2 interacting proteins
Published_or_final_versionObstetrics and GynaecologyMasterMaster of Philosoph
- 1 January 2002
- Published by The University of Hong Kong Libraries
Open AccessIdentification and characterization of VCY2 interacting proteins
Published_or_final_versionObstetrics and GynaecologyMasterMaster of Philosoph