Yvonne Hort
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Yvonne Hort has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Carla Cunha
I3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal
2 shared publications - John Shine
Garvan Institute of Medical Research, Australia; UNSW Sydney, Australia
2 shared publications - Kharen L. Doyle
Garvan Institute of Medical Research, Australia; UNSW Sydney, Australia
2 shared publications - Günther Sperk
Department of Pharmacology, Medical University Innsbruck, 6020 Innsbruck, Austria
1 shared publication - Herbert Herzog
University of New South Wales (UNSW)
1 shared publication - Ramon Osman Tasan
Department of Pharmacology, Medical University Innsbruck, Innsbruck, Austria
1 shared publication
Latest Publications
- 1 April 2018
- Published by Elsevier in Neuropeptides
- Vol. 68, 90-98
Role of neuropeptide Y (NPY) in the differentiation of Trpm-5-positive olfactory microvillar cells
- 1 April 2018
- Published by Elsevier in Neuropeptides
- Vol. 68, 90-98
Role of neuropeptide Y (NPY) in the differentiation of Trpm-5-positive olfactory microvillar cells
- Open Access
- 31 October 2012
- Published by Springer Nature in BMC Neuroscience
- Vol. 13 (1) , 134
Morphological and behavioural changes occur following the X-ray irradiation of the adult mouse olfactory neuroepithelium
Background: The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this study, X-rays were used to disrupt proliferating olfactory stem cell populations and to assess their role in the cellular and morphological changes involved in olfactory neurogenic processes. Results: We have analysed the histological and functional effects of a sub-lethal dose of X-rays on the adult mouse olfactory neuroepithelium at 2 hours, 24 hours, 1 week, 2 weeks and 5 weeks. We have shown an immediate cessation of proliferating olfactory stem cells as shown by BrdU, Ki67 and pH3 expression. At 24 hours there was an increase in the neural transcription factors Mash1 and Pax6 expression, and a disruption of the basal lamina and increase in glandular cell marker expression at 1 week post-irradiation. Coincident with these changes was an impairment of the olfactory function in vivo. Conclusions: We have shown significant changes in basal cell proliferation as well as morphological changes in the olfactory neuroepithelium following X-ray irradiation. There is involvement of the basal lamina as well as a clear role for glandular and sustentacular cells.
- 31 October 2012
- Published by Springer Nature in BMC Neuroscience
- Vol. 13 (1) , 134
Open AccessMorphological and behavioural changes occur following the X-ray irradiation of the adult mouse olfactory neuroepithelium
Background: The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this study, X-rays were used to disrupt proliferating olfactory stem cell populations and to assess their role in the cellular and morphological changes involved in olfactory neurogenic processes. Results: We have analysed the histological and functional effects of a sub-lethal dose of X-rays on the adult mouse olfactory neuroepithelium at 2 hours, 24 hours, 1 week, 2 weeks and 5 weeks. We have shown an immediate cessation of proliferating olfactory stem cells as shown by BrdU, Ki67 and pH3 expression. At 24 hours there was an increase in the neural transcription factors Mash1 and Pax6 expression, and a disruption of the basal lamina and increase in glandular cell marker expression at 1 week post-irradiation. Coincident with these changes was an impairment of the olfactory function in vivo. Conclusions: We have shown significant changes in basal cell proliferation as well as morphological changes in the olfactory neuroepithelium following X-ray irradiation. There is involvement of the basal lamina as well as a clear role for glandular and sustentacular cells.