Haibin Chen
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Haibin Chen has a total of 12 co-authors. Here are the top co-authors by number of shared publications:
- Anupam P. Gohel
Codexis, Inc., 200 Penobscot Drive, Redwood City, CA, 94063, USA
2 shared publications - Birgit Kosjek
Process Research and Development Merck & Co., Inc. Rahway NJ 07065 USA
2 shared publications - Derek J. Smith
Codexis, Inc., 200 Penobscot Drive, Redwood City, CA, 94063, USA
2 shared publications - Fabien L. Cabirol
Codexis, Inc., 200 Penobscot Drive, Redwood City, CA, 94063, USA
2 shared publications - Feng Xu
Department of Process Research, Merck Research Laboratory, Rahway, New Jersey 07065, USA
2 shared publications - Jacob M. Janey
Product Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903, United States
2 shared publications
Latest Publications
- 3 May 2018
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 57 (23) , 6863-6867
Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction
Described here is an efficient stereoselective synthesis of vibegron enabled by an enzymatic dynamic kinetic reduction that proceeds in a high‐pH environment. To overcome enzyme performance limitations under these conditions, a ketoreductase was evolved by a computationally and structurally aided strategy to increase cofactor stability through tighter binding.
- 3 May 2018
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 57 (23) , 6863-6867
Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction
Described here is an efficient stereoselective synthesis of vibegron enabled by an enzymatic dynamic kinetic reduction that proceeds in a high‐pH environment. To overcome enzyme performance limitations under these conditions, a ketoreductase was evolved by a computationally and structurally aided strategy to increase cofactor stability through tighter binding.
- 3 May 2018
- Published by Wiley in Angewandte Chemie
- Vol. 130 (23) , 6979-6983
Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction
Described here is an efficient stereoselective synthesis of vibegron enabled by an enzymatic dynamic kinetic reduction that proceeds in a high‐pH environment. To overcome enzyme performance limitations under these conditions, a ketoreductase was evolved by a computationally and structurally aided strategy to increase cofactor stability through tighter binding.
- 3 May 2018
- Published by Wiley in Angewandte Chemie
- Vol. 130 (23) , 6979-6983
Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction
Described here is an efficient stereoselective synthesis of vibegron enabled by an enzymatic dynamic kinetic reduction that proceeds in a high‐pH environment. To overcome enzyme performance limitations under these conditions, a ketoreductase was evolved by a computationally and structurally aided strategy to increase cofactor stability through tighter binding.