Sandra Boiteux
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Sandra Boiteux has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Abu Hasanat Md. Zulfiker
Department of Pharmaceutical Sciences and Research, School of Pharmacy, Marshall University, Huntington, WV, 25701, USA
1 shared publication - Milton John Kiefel
School of Environment and Science, Griffith University, Southport, QLD 4222, Australia
1 shared publication - Ming-Qian Wei
School of Pharmacy and Medical Sciences Griffith University Gold Coast Australia
1 shared publication - Tamim Mosaiab
Institute for Glycomics, Griffith University, Southport, QLD 4222, Australia
1 shared publication - Todd A. Houston
AInstitute for Biomedicine & Glycomics, Gold Coast Campus, Griffith University, Qld 4222, Australia
1 shared publication
Latest Publications
- 6 June 2018
- Published by Wiley in ChemBioChem
- Vol. 19 (14) , 1476-1481
A Simple Glycolipid Mimic of the Phosphatidylinositol Mannoside Core from Mycobacterium tuberculosis Inhibits Macrophage Cytokine Production
Glycolipids from Mycobacterium tuberculosis have a profound impact on the innate immune response of the host. Macrophage‐inducible C‐type lectin (Mincle) is a pattern‐recognition receptor that has been shown to bind trehalose dimycolate (TDM) from the mycobacterium and instigate intracellular signalling in the immune cell. There are structural similarities between the structures of TDM and phosphatidyl inositol mannoside (PIM). We thus hypothesized that these latter structures might also modulate an immune response in a similar manner. To test this, we synthesized a series of new mannose derivatives modified with fatty esters at the 6‐position and assessed the release of inflammatory cytokines in human U937 macrophages under the induction of lipopolysaccharides (LPS) after glycolipid treatment. The results showed that the amount of two major cytokines—tumour necrosis factor (TNF)‐α and interleukin (IL)‐6—released from LPS‐stimulated U937 cells decreased significantly when compared to a control upon treatment with the prepared glycolipids, thus indicating a reduction in cytokine production by the macrophages.
- 6 June 2018
- Published by Wiley in ChemBioChem
- Vol. 19 (14) , 1476-1481
A Simple Glycolipid Mimic of the Phosphatidylinositol Mannoside Core from Mycobacterium tuberculosis Inhibits Macrophage Cytokine Production
Glycolipids from Mycobacterium tuberculosis have a profound impact on the innate immune response of the host. Macrophage‐inducible C‐type lectin (Mincle) is a pattern‐recognition receptor that has been shown to bind trehalose dimycolate (TDM) from the mycobacterium and instigate intracellular signalling in the immune cell. There are structural similarities between the structures of TDM and phosphatidyl inositol mannoside (PIM). We thus hypothesized that these latter structures might also modulate an immune response in a similar manner. To test this, we synthesized a series of new mannose derivatives modified with fatty esters at the 6‐position and assessed the release of inflammatory cytokines in human U937 macrophages under the induction of lipopolysaccharides (LPS) after glycolipid treatment. The results showed that the amount of two major cytokines—tumour necrosis factor (TNF)‐α and interleukin (IL)‐6—released from LPS‐stimulated U937 cells decreased significantly when compared to a control upon treatment with the prepared glycolipids, thus indicating a reduction in cytokine production by the macrophages.