Dmitri Colesnic
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Dmitri Colesnic has a total of 12 co-authors. Here are the top co-authors by number of shared publications:
- Adélie Gothland
Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, laboratoire de virologie, F-75013 Paris, France
2 shared publications - Anne-Geneviève Marcelin
Sorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, AP-HP, Hôpitaux Universitaires Pitié-Salpêtrière-Charles Foix, Laboratoire de Virologie, 75013 Paris, France
2 shared publications - Damien Baigl
CPCV, Department of Chemistry, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, 75005 Paris, France
2 shared publications - Gaëlle Pembouong
Sorbonne Université, CNRS Institut Parisien de Chimie Moléculaire, IPCM Paris F‐75005 France
2 shared publications - Julien Rossignol
Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, UMR 8232, 4 Place Jussieu, 75005, Paris, France
2 shared publications - Laurent Bouteiller
Sorbonne Université, CNRS Institut Parisien de Chimie Moléculaire, IPCM Paris F‐75005 France
2 shared publications
Latest Publications
- 25 May 2018
- Published by Wiley in Angewandte Chemie
- Vol. 130 (26) , 7879-7884
Bridging β‐Cyclodextrin Prevents Self‐Inclusion, Promotes Supramolecular Polymerization, and Promotes Cooperative Interaction with Nucleic Acids
- 25 May 2018
- Published by Wiley in Angewandte Chemie
- Vol. 130 (26) , 7879-7884
Bridging β‐Cyclodextrin Prevents Self‐Inclusion, Promotes Supramolecular Polymerization, and Promotes Cooperative Interaction with Nucleic Acids
- 25 May 2018
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 57 (26) , 7753-7758
Bridging β‐Cyclodextrin Prevents Self‐Inclusion, Promotes Supramolecular Polymerization, and Promotes Cooperative Interaction with Nucleic Acids
To imitate Nature's ability to form cooperative self‐assemblies using entirely artificial molecular tools and to confer them with properties is still a true challenge. Here we show that cyclodextrins bridged with an ammonium linker which bears a hydrophobic substituent efficiently form supramolecular polymers at millimolar concentrations, avoiding the competing self‐inclusion and head‐to‐head processes. Notably, such assembly can occur at micromolecular concentrations in the presence of genomic DNA, resulting in efficient DNA compaction that is reversible upon addition of a competitive guest, and demonstrating their highly cooperative interaction. We finally show that the supramolecular polymer also cooperatively interacts with siRNA and allows its transfection.
- 25 May 2018
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 57 (26) , 7753-7758
Bridging β‐Cyclodextrin Prevents Self‐Inclusion, Promotes Supramolecular Polymerization, and Promotes Cooperative Interaction with Nucleic Acids
To imitate Nature's ability to form cooperative self‐assemblies using entirely artificial molecular tools and to confer them with properties is still a true challenge. Here we show that cyclodextrins bridged with an ammonium linker which bears a hydrophobic substituent efficiently form supramolecular polymers at millimolar concentrations, avoiding the competing self‐inclusion and head‐to‐head processes. Notably, such assembly can occur at micromolecular concentrations in the presence of genomic DNA, resulting in efficient DNA compaction that is reversible upon addition of a competitive guest, and demonstrating their highly cooperative interaction. We finally show that the supramolecular polymer also cooperatively interacts with siRNA and allows its transfection.