Sevgi Ayhan

Background: The aim of this study was to evaluate the serous borderline ovarian tumours (BOTs), the recurrence rates, and the factors affecting recurrence. Methods: A total of 165 patients diagnosed with serous BOT between 2004 and 2019 were included. The patients were evaluated in respect of age, preoperative CA125 levels, FIGO stage, tumour size, stromal micro-invasion, the presence of non-invasive implants, surgical procedures, and lymphadenectomy performed, or all that affects disease-free survival. Results: Early-stage BOT (stage I–II) was determined in 149 (90.3%) patients. Conservative surgery was performed in 57 (34.5%) patients. The non-invasive implantation was detected in 19 (11.5%) patients, and micro-invasion was determined in 31 (18.8%) patients. The median follow-up was 120 months, and recurrence was observed in 8 (4.8%) patients. The 5-year disease-free survival rate was 95.2%, and the 10-year disease-free survival rate was also 95.2%. Univariate analysis showed that elevated preoperative CA125 levels and the presence of micro-invasion were associated with poor disease-free survival outcomes. In the multivariate analysis, the presence of micro-invasion was the only independent poor prognostic factor (HR: 8.944, 95%CI: 2.060–38.833; p:0.003). Conclusions: The micro-invasion was the main factor for recurrence in patients with serous BOT.

Aim: The aim of this study is evaluating the predictive value of preoperative inflammatory blood parameters for differential of serous cystadenoma, serous borderline ovarian tumor (BOT) and high-grade serous ovarian (HGSOC) carcinoma. Materials and Method: In this single-center study, we retrospectively enrolled 370 patients with ovarian tumors were divided into three groups. The groups were classified as serous cystadenoma, serous BOT and HGSOC. The potential association of preoperative hemoglobin (Hb), red cell distribution width (RDW), Hb/RDW ratio, ratio of neutrophils to lymphocytes (N/L) and ratio of platelets to lymphocytes (P/L) were analyzed. Results: P/L and N/L were significantly lower in benign serous cystadenoma or serous BOT than HGSOC (p

Amaç: Serviks kanseri hastalarında lenf nodu metastazının (LNM) değerlendirmesi tedavinin bireyselleştirilmesi için önemli bir konudur. Çalışmamızın amacı, serviks kanserli hastalarda LNM'nin prediktif faktörlerini belirlemektir. Gereç ve Yöntem: Bu retrospektif çalışmaya, 2007'den 2019'a kadar Uluslararası Jinekoloji ve Obstetrik Federasyonu (FIGO) evre IB1-IIA2'nin serviks kanseri hastaları dahil edildi. LNM insidanslarıyla beraber tek ve çok değişkenli modellerde pelvik ve paraaortik LNM için risk faktörlerinin prediktif değeri belirlendi. Bulgular: Çalışmaya dahil edilen 212 hastadan pelvik LNM olan hasta sayısı 81(%38.2), paraaortik LNM'li hasta sayısı 17(%8) idi. Serviks kanseri hastalarında multivariyant analize göre parametriyal tutulum (hazard ratio [HR]: 2.75, 95% confidence interval [CI], 1.18-6.40, p=0.019) ve lenfovasküler tutulum ([HR]: 3.83, 95% [CI], 1.76-8.38, p=0.001) pelvik LNM için bağımsız risk faktörleriydi iken paraaortik LNM için parametriyal tutulum bağımsız risk faktörüydü ([HR]: 3.62, 95% [CI], 1.20-10.98, p=0.023). Sonuç: Serviks kanseri hastalarında pelvik LNM'nin prediktif faktörleri parametrial tutulum ve LVSI iken paraaortik LNM için prediktif risk faktörü parametrial tutulumdu.

We investigated the association between preoperative ratios of inflammatory markers and the prognosis in patients with invasive cervical cancer (CC). In this single-centre study, we retrospectively enrolled 163 CC patients who underwent radical hysterectomy between February 2008 and October 2018. Among the evaluated ratios, a high neutrophil-to-lymphocyte ratio (N/L) was significantly associated with deep stromal invasion and tumour size larger than 2 cm, whereas a high M/L was significantly related to advanced-stage CC (IB3–IIIC2), lymphatic metastasis (total) and pelvic lymph node metastasis (p= .002, p= .046 and p= .046, respectively). The neutrophil count plus monocyte-to-lymphocyte ratio (NM/L) and platelet-to-lymphocyte ratio (P/L) were significantly higher in patients with deep stromal invasion, advanced stage and tumour size larger than 2 cm (p=.01, p=.044 and p=.007; p=.004, p=.005 and p=.003, respectively). In the multivariate analysis, high NM/L (>168) was associated with a statistically significant hazard ratio of 3.04 (95% CI: (1.38–6.72); p=.006) for recurrence and 9.05 (95% CI: (2.10–38.99); p=.003) for death. Both stage and NM/L are independent prognostic factors that are significantly associated with recurrence and overall survival in CC.

Aim: To evaluate the clinico‐pathologic features, treatment options, prognostic factors, and survival outcomes of malignant struma ovarii based on a systematic literature review in association with our case study.Methods: A systematic review of the medical literature was performed to identify articles about malignant struma ovarii from January 1983 until July 2020. We evaluated 178 cases.Results: The 5‐year progression‐free survival (PFS) and overall survival (OS) of the entire cohort was 72.5% and 91%, respectively. In univariate analysis, younger age (95 mm, presence of a histologic type other than papillary classic‐type thyroid carcinoma within the tumor and lymphovascular space invasion were related to poor PFS. Patients who received radioactive iodine ablation (RIA) before the treatment failure had significantly higher PFS than those who did not receive RIA (94.9% vs. 64.8%, p = 0.041, respectively). In univariate analysis, PFS was significantly higher in patients who underwent gynecologic surgery followed by thyroidectomy and RIA compared with those who had surgical treatment only (94.5% vs. 64.3%, p = 0.05, respectively). However, this result could not be identified as an independent prognostic factor in multivariate analysis (p = 0.207). Younger age and absence of capsular involvement were related to significantly increased OS. Histologic type was the only independent prognostic factor for PFS (hazard ratio: 3.30, 95% confidence interval: 1.122–9.748; p = 0.030)Conclusion: The most common histologic subtype was the papillary classic type. The presence of a histologic type other than the classic papillary thyroid carcinoma within the tumor was an independent adverse prognostic factor.

Objectives: Child sexual abuse is associated with adverse outcomes, including increased vulnerability, that may explain the risk of revictimization via cyber media and cyber abuse may be a risk factor for sexual abuse. The aims of the study were to explore cyber abuse prevalence in sexual abuse cases, the direct and indirect links between child sexual abuse and cyber abuse and to study the differences in internet use between children and adolescents who were sexually abused and the control group. Methods: We assessed 75 children and adolescents aged 7-18 who had experienced sexual abuse and were referred to us between 01.01.2014-01.01.2015. Additionally, 45 typical developing subjects who did not have any abuse history were recruited from pediatrics clinic of or hospital as the control group. We used our semi-structured questionnaire to assess cyber abuse. Results: The rates of internet use were high in the control group (97.8%) compared to those of sexually abused teens (82.7%). However, the rates of cyber abuse were similar between the groups. The most used web site/application was different between the groups. Facebook was the most used web site/application in the sexually abused group (69.4%). This ratio was only 20.5% in the control group. Conclusions: We assessed cyber abuse in a population exposed to sexual abuse. As several authors have previously emphasized, the implementation of preventative steps is essential. There is a great need to develop and evaluate interventions with those children and young people, particularly in sexually abused children and adolescents who are thought to be more vulnerable to cyber abuse.

Amaç: Sezaryen ile doğumun postpartum depresyona ve maternal bağlanmaya etkisini incelemek Gereç ve Yöntem: Sezaryen doğum yapan 90 kadın ve vajinal doğum yapan 90 kadın çalışmaya dahil edilmiştir. Tüm kadınlara postpartum 2. Haftada depresif belirtilerinin taranması için Edinburg Doğum Sonrası Depresyon Ölçeği, maternal bağlanmanın değerlendirilmesi için ise Maternal Bağlanma Ölçeği uygulanmıştır. Bulgular: İki grup arasında Edinburg Doğum Sonrası Depresyon Ölçeği ve Maternal Bağlanma Ölçeği ortalama puanları açısından istatistiksel olarak anlamlı bir fark yoktu. Ayrıca gruplardaki postpartum depresyon gelişimi için riskli olabilecek puanlara (Edinburg Doğum Sonrası Depresyon Ölçeği puanı >12 olanlar) sahip kadın sıklığı da benzerdi. Sonuç: Sezaryen ile doğumun postpartum depresyona ve maternal bağlanmaya etkisi yoktur.