Avanish Singh Parmar

We utilized fluorescent boron and nitrogen co-doped carbon nanodots (BNCDs) for the optical detection of 4-nitrophenol ( p -NP), 2,4-dinitrophenol (DNP), and 2,4,6-trinitrophenol (TNP) in water.

Fabrication and characterization of MTX-MWCNT nanoconjugate for evaluation of its cytotoxic activity, hemocompatibility, anti-angiogenic potential, molecular expression and morphological alterations through in vitro assays.

Polymeric nanoparticles provide an effective platform for drug delivery owing to their biocompatibility, biodegradability, and high drug-loading capacity (created with Biorender.com).

Deep muscle wound healing presents significant clinical challenges due to the complex architecture of tissues, high susceptibility to infection, and often prolonged regenerative processes, particularly following trauma or surgical interventions. To overcome limitations associated with conventional dressings such as poor adherence, mechanical weakness, and frequent replacements, we developed a self-adhering multifunctional composite hydrogel system integrating amyloidogenic bovine serum albumin (BSA) fibrils with fenugreek seed extract (FE). The hydrogel was engineered in two topical formulations: a mechanically robust patch and a spreadable ointment. This multifunctional platform combines the structural integrity and biocompatibility of amyloid fibrils with the bioactive antioxidant, anti-inflammatory, and antimicrobial properties of fenugreek phytochemicals. Comprehensive physicochemical characterization confirmed successful hydrogelation with porous microstructures (50-200 μm) conducive to cellular infiltration and moisture retention. FTIR and rheological analyses revealed significant intermolecular interactions and tunable viscoelastic solid-like behavior. The patch demonstrated superior mechanical strength and adhesion, whereas the ointment offered facile application to irregular wound contours. Both formulations exhibited approximately 87% free radical scavenging capacity, potent antibacterial efficacy against Escherichia coli and Bacillus subtilis, and excellent biocompatibility with >95% viability of human embryonic kidney (HEK) cells. In a rabbit full-thickness muscle wound model, both treatments accelerated wound closure, achieving complete epithelialization by day 21, with minimal fibrosis and well-organized collagen regeneration. Importantly, the patch's self-adhering property obviated the need for secondary dressings. This study introduces a promising therapeutic hydrogel system with potential for clinical translation in managing complex musculoskeletal wounds.

Burn wounds present a significant clinical challenge, often leading to prolonged healing, infection, and substantial scarring.

Injectable hydrogel containing N -acetylglycine acts as GCase stabilizer.

Natural polymer-based hydrogels closely mimic the extracellular matrix, making them ideal for supporting cell growth and tissue regeneration. Recent advancements in tuning their porosity, morphology, and size have helped overcome key challenges in tissue engineering, such as vascularization and multicellular integration. However, their clinical use is often limited by drawbacks, such as low mechanical strength, structural instability, high production costs, and limited reproducibility. In this work, we present a skin-adhesive, 3D-printable/injectable hybrid hydrogel composed of natural protein and cellulose. This hybrid hydrogel overcomes the limitations of conventional systems by enhancing mechanical strength, scaffold stability, reproducibility, cost-effectiveness, and adhesive properties while preserving high biocompatibility and biodegradability. Using the same formulation, a wound dressing material is fabricated and applied at the wound site either by suturing or as an adhesive film. Furthermore, the hydrogel exhibits inherent antibacterial, antioxidant (60% of radical scavenging), anti-inflammatory, cell viability (up to 90%), and cell migration properties that significantly promote wound healing. This multifunctional hybrid hydrogel offers a promising solution for next-generation wound dressing applications and contributes to the advancement of bioactive and customizable materials in regenerative medicine.

Lead (Pb) based perovskite solar cells (PSCs) have an impressively high-power conversion efficiency (PCE). However, the commercialization of these PSCs is significantly hindered by Pb toxicity. The present work examines the impact of Ag doping in ZnSe electron transport layer (ETL) for the better performance of all inorganic CuBiSCl₂ PSCs by using SCAPS-1D simulation package. The photovoltaic parameters were optimized by adjusting the perovskite layer thicknesses and charge transport layers (CTLs), along with doping concentration, interfacial defect density. Additionally, optimizing series and shunt resistance significantly enhances PSC performance, with optimal value of 1 Ω·cm² and 6000 Ω·cm², respectively, leading to improved PCE and reduces resistive losses. The most efficient PSC with PCE of 29.36%, V_OC = 1.10 V, J_SC = 32.57 mA cm⁻², and FF = 81.76 % was attained with the structure of FTO/Ag-ZnSe/CuBiSCl₂/Cu₂O. The effect of doping of Ag in ZnSe ETL was proven to be better choice for efficient CuBiSCl₂ PSC. Further, this study examined the performance of optimized PSC in terms of capacitance-voltage, mott—Schottky, and Nyquist plot. The achieved PCE of 29.36% is significantly higher than the previously reported 1.00% for CuBiSCl₂-based solar cells using TiO₂ as the ETL. This investigation highlights the effectiveness of Ag-doped ZnSe as an ETL by offering the better electron mobility and band alignment and in the solar cell. These findings establish CuBiSCl₂ as a promising active layer for high-performance, eco-friendly, and all inorganic PSCs.