Samuel Guay

The cardiac response to physical exertion is linked to factors such as age, work intensity, and fitness levels. The primary objective of this study was to characterize within-session changes in cardiac response to running in Canadian football athletes, which may indicate physical fatigue. Performance profiles were collected from GPS and heart rate (HR) sensors worn by 30 male Canadian varsity football players (20–26 years old) over 28 games and practices. Running efforts with 60–180 s of rest were detected, and the maximum HR (HRmax) and peak HR recovery (HRRpk) during rest were extracted. Additionally, a new metric of cardiovascular cost (CVC) was developed to reflect the efficiency of the HR response to physical workload. HRmax was higher in games (p < 0.001) and in linemen (p < 0.001), and it increased over time (p < 0.001). HRRpk was higher in skilled players (p < 0.001) and changed over time (p < 0.001) depending on the rest period. CVC was higher in linemen (p < 0.001) and increased over time (p < 0.001). This study demonstrated the utility of HR response metrics to quantify ongoing fatigue experienced by Canadian football athletes and proposed a novel fatigue metric capable of monitoring an athlete’s fatigue state in real time.

This study aimed to use a data-driven approach to identify individualized speed thresholds to characterize running demands and athlete workload during games and practices in skill and linemen football players. Data were recorded from wearable sensors over 28 sessions from 30 male Canadian varsity football athletes, resulting in a total of 287 performances analyzed, including 137 games and 150 practices, using a global positioning system. Speed zones were identified for each performance by fitting a 5-dimensional Gaussian mixture model (GMM) corresponding to 5 running intensity zones from minimal (zone 1) to maximal (zone 5). Skill players had significantly higher (p < 0.001) speed thresholds, percentage of time spent, and distance covered in maximal intensity zones compared to linemen. The distance covered in game settings was significantly higher (p < 0.001) compared to practices. This study highlighted the use of individualized speed thresholds to determine running intensity and athlete workloads for American and Canadian football athletes, as well as compare running performances between practice and game scenarios. This approach can be used to monitor physical workload in athletes with respect to their tactical positions during practices and games, and to ensure that athletes are adequately trained to meet in-game physical demands.

Subconcussive hits to the head and physical fitness both have been associated with alterations in white matter (WM) microstructure in partly overlapping areas of the brain. The aim of the present study was to determine whether WM damage associated with repeated exposure to subconcussive hits to the head in university level contact sports athletes is modulated by high levels of fitness. To this end, 72 students were recruited: 24 athletes practicing a varsity contact sport (A-CS), 24 athletes practicing a varsity non-contact sport (A-NCS), and 24 healthy non-athletes (NA). Participants underwent a magnetic resonance imaging session that included diffusion-weighted imaging. Between-groups, statistical analyses were performed with diffusion tensor imaging measures extracted by tractometry of sections of the corpus callosum and the corticospinal tract. Most significant effects were found in A-NCS who exhibited higher fractional anisotropy (FA) values than A-CS in almost all segments of the corpus callosum and in the corticospinal tract. The A-NCS also showed higher FA compared with NA in the anterior regions of the corpus callosum and the corticospinal tracts. No group difference was found between the A-CS and the NA groups. These data suggest that repeated subconcussive hits to the head lead to anisotropic changes in the WM that may counteract the beneficial effects associated with high levels of fitness.

Concussions/mild traumatic brain injury (mTBI) represent a major public health concern due to persistent behavioral and neurological effects. The mechanisms by which concussions lead to such effects are partly attributable to an hyperacute indiscriminate glutamate release. Cerebral microdialysis studies in rodents reported a peak of extracellular glutamate 10 minutes after injury. Microdialysis has the advantage of being one of the few techniques allowing the quantification of neurotransmitters in vivo and at different time points following injury. In addition to the clear advantages afforded by microdialysis, the Wayne State weight-drop model induces an impact on the skull of a subject unrestrained by the fall of a weight. The latter model allows rapid acceleration and deceleration of the head and torso, an essential feature in human craniocerebral trauma and a factor that is missing from many existing animal concussion models. In the present study, we applied the Wayne State procedure and microdialysis to document, in awake rats, the acute changes in extracellular hippocampal glutamate and GABA levels resulting from concussive trauma. We studied the dorsal CA1 hippocampal region as it contains a high density of glutamatergic terminal and receptors, thus making it vulnerable to excitotoxic insult. Using HPLC, dialysate levels of hippocampal glutamate and GABA were measured in adult male Sprague-Dawley rats in 10 min increments for 60 min prior to, during and for 90 min following concussive trauma induced by the Wayne State weight-drop procedure. Sham control animals were treated in the same manner but without receiving the concussive trauma procedure. Our results show that concussive trauma is followed, within 10 min, by a robust, transient 3-fold increase in hippocampal glutamate levels; such changes were not seen in controls. In contrast, GABA levels were unaffected by the concussive trauma procedure. The findings derived from the approach used here are generally consistent with those of previous other studies. They also provide a crucial in vivo validation of the Wayne State procedure as a model with promising translational potential for pre-clinical studies on early therapeutic responses to concussion.