Josephine Jackisch

Purpose: Family-based interventions are proposed for primordial cardiovascular disease (CVD) prevention, yet which family-environment components to target remains unclear. We quantified effects of parenting styles in adolescence on adult cardiovascular conditions, including hypertension, and whether effects differ by family financial hardship. Methods: Data were from the US National Longitudinal Study of Adolescent to Adult Health (n=4,050). Parenting styles were derived via latent class analysis of adolescent-reported parental responsiveness and demandingness (ages 12–19, 1994–1995). Family financial hardship was based on parent-reported ability to pay bills. CVD and hypertension were assessed via biomarkers and self-report (ages 33–43, 2016–2018). Confounding factors were selected based on a directed acyclic graph; risk differences were estimated using doubly robust inverse-probability-weighted models. Results: Three parenting styles emerged: authoritative (11.1%), permissive (77.9%), and indifferent (11.0%). After 21 years, 33.0% had CVD or hypertension. Whole-population risk differences for permissive and indifferent versus authoritative parenting were -1.0% (95% CI: -5.3, 3.3%) and -1.8% (95% CI: -7.8, 4.2%), respectively. Among families reporting financial hardship, permissive parenting had lower risk (-15.9%, 95%CI: -28.4%, -3.3%), though inconsistent across sensitivity analyses. Conclusions: Adolescent parenting styles had small estimated long-term cardiovascular effects, with no robust evidence of differences by financial hardship.

Background: Adolescent health risk behaviors may have unequal effects on adult cardiovascular diseases (CVDs) and hypertension, with individuals from disadvantaged socioeconomic backgrounds potentially experiencing stronger harmful effects due to heightened susceptibility. Using data from the US National Longitudinal Study of Adolescent to Adult Health, we quantified differential effects of adolescent health behaviors on CVDs and hypertension by family financial situation. Methods: We identified behavior clusters via latent class modeling and estimated effects using double-robust inverse probability weighted methods. Exposures were adolescent health risk behaviors (breakfast skipping, cigarette smoking, frequent alcohol use, and infrequent physical activity), measured at ages 12–19 (1994–1995, n=4452), with parental difficulty paying bills as the effect modifier. CVDs and hypertension were assessed at ages 33–43 (2016–2018) using biomarkers and self-reports. Results: After 21 years, 33.2% of participants had CVD or hypertension. Frequent alcohol use and concurrent cigarette smoking led to 11.1 percentage points more cases (95% CI: 0.1–22.1) among adolescents with parental financial difficulty compared to peers without. Alcohol use alone exhibited a differential effect of 9.7 percentage points (95% CI: 0.8–18.5). The differential effect of breakfast skipping was inconsistent across sensitivity analyses, and no strong evidence was found for infrequent physical activity. Conclusions: These findings from a US cohort indicate that frequent alcohol use in adolescence, particularly with concurrent smoking, increases risk of adult CVD and hypertension unequally based on socioeconomic background. This differential susceptibility suggests that population-level interventions targeting alcohol use and concurrent smoking could help reduce cardiovascular inequalities.

Adolescent healthy behaviours may improve cardiometabolic health in adulthood differently across socioeconomic groups. We aimed to quantify the effects of adolescent healthy behaviours on multiple biomarkers of adult cardiometabolic health by socioeconomic backgrounds. We used a population-based cohort of Finnish adolescents from the Young Finns Study (1980–89, n = 2984) followed into adulthood (2001–11). Healthy behaviours (no smoking, no alcohol consumption, sufficient physical activity, daily fruit and vegetable consumption) and socioeconomic backgrounds (parental- and neighbourhood-related) were measured in adolescence (12–18 years). Biomarkers of adiposity [waist circumference, body mass index (BMI)], cardiovascular [blood pressure (BP), cholesterol, apolipoprotein B], and metabolic [plasma glucose, insulin resistance] outcomes were measured in adulthood (33–40 years). We estimated conditional average effects of healthy behaviours via inverse-probability-weighted marginal structural models. Sufficient physical activity lowered adiposity biomarkers to a greater extent among adolescents from disadvantaged neighbourhood, with additional decreases of 2.2 cm [95% confidence interval (CI): −0.1 to 4.7] in waist circumference and 1 kg/m2 (95% CI: 0.2 to 1.9) in BMI. In contrast, daily fruit and vegetable consumption lowered BP with additional 2.0–3.6 mmHg (95% CI: 0.3 to 6.1) among adolescents with advantaged either parental or neighbourhood socioeconomic backgrounds. There was little evidence for differential effects on other outcomes and for no smoking and alcohol. Socioeconomic backgrounds modified the effects of adolescent physical activity and fruit and vegetable consumption on adult cardiometabolic health. These findings indicate that population-wide interventions promoting healthy behaviours during adolescence have the potential to either mitigate or exacerbate long-term socioeconomic inequalities in cardiometabolic health.

"A reply to ‘Social-to-biological transitions research: review of progress and development’ by Thomas O’Toole et al" published on 26 Apr 2024 by Bristol University Press.

Purpose The Swedish Families of the 1990s (SWIFT90) is a population-based national register cohort that follows everyone born between 1990 and 1999, their parents and siblings. The cohort was set up primarily to investigate factors associated with biological parents’ involvement with child welfare services and their outcomes following child(ren) placement in out-of-home care (OHC) under the research project ‘Drivers of inequalities of families involved in child welfare services (DRIVERS)’. Participants This cohort is defined as families consisting of parents and their children, of which at least one was born between 1990 and 1999 in Sweden, which totals 1 075 037 children. The children are linked to both (adoptive or biological) parents and their siblings, so the total number of individuals in the SWIFT90 yields a total sample of n=3 292 417. These families are followed through multiple national registers including information on income, education, inpatient care, mortality and criminal offences. SWIFT90 compiles administrative data spanning from 1960 to 2022, which reflects the most recent data available at the time of the data request. Findings to date SWIFT90 provides information on 61 982 parents (fathers=31 028; mothers=30 954) with children placed in OHC and their respective children (38,084). Several covariates could be assessed for the parental generation, therefore, providing a comprehensive picture of socioeconomic and health-related aspects of families with children born in the 1990s and placed in OHC in Sweden. Future plans SWIFT90 will be used to investigate the socioeconomic and health trajectories of families involved with the child welfare system. With this cohort study ia possible to examine whether the inclusion of certain covariates alters the association between parental characteristics and child welfare outcomes. Future studies could also guide initiatives to prevent vulnerable circumstances among biological parents from escalating to the point where child placement into OHC becomes necessary. Additionally, they could help enhance the conditions of biological families and support opportunities for reunification after placement has occurred.

Introduction Adolescence is a sensitive period for cardiometabolic health. Yet, it remains unknown if adolescent health behaviours, such as alcohol use, smoking, diet and physical activity, have differential effects across socioeconomic strata. Adopting a life-course perspective and a causal inference framework, we aim to assess whether the effects of adolescent health behaviours on adult cardiometabolic health differ by levels of neighbourhood deprivation, parental education and occupational class. Gaining a better understanding of these social disparities in susceptibility to health behaviours can inform policy initiatives that aim to improve population health and reduce socioeconomic inequalities in cardiometabolic health. Methods and analysis We will conduct a secondary analysis of the Young Finns Study, which is a longitudinal population-based cohort study. We will use measures of health behaviours—smoking, alcohol use, fruit and vegetable consumption, and physical activity—as exposure and parental education, occupational class and neighbourhood deprivation as effect modifiers during adolescence (ages 12–18 years). Eight biomarkers of cardiometabolic health (outcomes)—waist circumference, body mass index, blood pressure, low-density lipoprotein cholesterol, apolipoprotein B, plasma glucose and insulin resistance—will be measured when participants were aged 33–40. A descriptive analysis will investigate the clustering of health behaviours. Informed by this, we will conduct a causal analysis to estimate effects of single or clustered adolescent health behaviours on cardiometabolic health conditional on socioeconomic background. This analysis will be based on a causal model implemented via a directed acyclic graph and inverse probability-weighted marginal structural models to estimate effect modification. Ethics and dissemination The Young Finns study was conducted according to the guidelines of the Declaration of Helsinki, and the protocol was approved by ethics committees of University of Helsinki, Kuopio, Oulu, Tampere and Turku. We will disseminate findings at international conferences and a manuscript in an open-access peer-reviewed journal.

Background: Individuals who were separated from their biological family and placed into the care of the state during childhood (out-of-home care) are more prone to developing selected physical and mental health problems in adulthood, however, their risk of cardiovascular disease (CVD) is uncertain. Accordingly, we pooled published and unpublished results from cohort studies of childhood care and adult CVD. Methods: We used two approaches to identifying relevant data on childhood care and adult CVD (PROSPERO registration CRD42021254665). First, to locate published studies, we searched PubMed (Medline) until November 2023. Second, with the aim of identifying unpublished studies with the potential to address the present research question, we scrutinised retrieved reviews of the impact of childhood state care on related adult health outcomes. All included studies were required to have prospective measurement of state care in childhood and a follow-up of CVD events in adulthood as the primary outcome (incident coronary heart disease and/or stroke). Collaborating investigators provided study-specific estimates which were aggregated using random-effects meta-analysis. The Newcastle-Ottawa Scale was used to assess individual study quality. Findings: Thirteen studies (2 published, 11 unpublished) met the inclusion criteria, and investigators from nine provided viable results, including updated analyses of the published studies. Studies comprised 611,601 individuals (301,129 women) from the US, UK, Sweden, Finland, and Australia. Relative to the unexposed, individuals with a care placement during childhood had a 50% greater risk of CVD in adulthood (summary rate ratio after basic adjustment [95% confidence interval]: 1.50 [1.22, 1.84]); range of study-specific estimates: 1.28 to 2.06; I ² = 69%, p = 0.001). This association was attenuated but persisted after multivariable adjustment for socioeconomic status in childhood (8 studies; 1.41 [1.15, 1.72]) and adulthood (9 studies, 1.28 [1.10, 1.50]). There was a suggestion of a stronger state care-CVD association in women. Interpretation: Our findings show that individuals with experience of state care in childhood have a moderately raised risk of CVD in adulthood. For timely prevention, clinicians and policy makers should be aware that people with a care history may need additional attention in risk factor management. Research in context: Evidence before this study: There is growing evidence that individuals who were separated from their biological family and placed into the care of the state during childhood (out-of-home care) are more prone to developing selected physical and mental ill-health in adulthood, however, their risk of cardiovascular disease (CVD) events is uncertain. A search of electronic databases to November 2023 yielded only 2 relevant published studies and these had discordant findings. Added value of this study: By scrutinising retrieved reviews of the impact of childhood state care on broadly related adult health outcomes, we identified studies with the potential to examine the association between childhood care and adult CVD events. Investigators from 7 provided these previously unpublished results and, on aggregating them alongside updated analyses from the 2 published studies, we found that, relative to their unexposed peers, adults with experience of state care earlier in life had a 50% greater risk of CVD. There was evidence that this relationship was partially mediating by socioeconomic status in adulthood, and there was a suggestion of a stronger state care–CVD association in women. Implications of all the available evidence: This meta-analysis suggests that, alongside the array of well-document unfavourable social, behavioural, and health outcomes in adulthood, children experiencing state care may additionally have a higher burden of later CVD. For timely prevention, clinicians and policy makers should be aware that people with a care history may need additional attention in risk factor management.