K. Cameron Falkner
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
K. Cameron Falkner has a total of 13 co-authors. Here are the top co-authors by number of shared publications:
- Banrida Wahlang
Hepatobiology and Toxicology Center, University of Louisville, Louisville, KY 40202, USA
2 shared publications - Jian Jin
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, USA
2 shared publications - Josiah E. Hardesty
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY 40202, USA
2 shared publications - Matthew C. Cave
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville, Louisville, KY 40202, USA
2 shared publications - Russell A. Prough
Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40202, USA
2 shared publications - Corey T. Watson
Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40292, USA
1 shared publication
Latest Publications
- 27 May 2019
- Published by Springer Nature in Current Environmental Health Reports
- Vol. 6 (3) , 80-94
Mechanisms of Environmental Contributions to Fatty Liver Disease
Purpose Fatty liver disease (FLD) affects over 25% of the global population and may lead to liver-related mortality due to cirrhosis and liver cancer. FLD caused by occupational and environmental chemical exposures is termed “toxicant-associated steatohepatitis” (TASH). The current review addresses the scientific progress made in the mechanistic understanding of TASH since its initial description in 2010. Recent Findings Recently discovered modes of actions for volatile organic compounds and persistent organic pollutants include the following: (i) the endocrine-, metabolism-, and signaling-disrupting chemical hypotheses; (ii) chemical-nutrient interactions and the “two-hit” hypothesis. These key hypotheses were then reviewed in the context of the steatosis adverse outcome pathway (AOP) proposed by the US Environmental Protection Agency. Summary The conceptual understanding of the contribution of environmental exposures to FLD has progressed significantly. However, because this is a new research area, more studies including mechanistic human data are required to address current knowledge gaps.
- 27 May 2019
- Published by Springer Nature in Current Environmental Health Reports
- Vol. 6 (3) , 80-94
Mechanisms of Environmental Contributions to Fatty Liver Disease
Purpose Fatty liver disease (FLD) affects over 25% of the global population and may lead to liver-related mortality due to cirrhosis and liver cancer. FLD caused by occupational and environmental chemical exposures is termed “toxicant-associated steatohepatitis” (TASH). The current review addresses the scientific progress made in the mechanistic understanding of TASH since its initial description in 2010. Recent Findings Recently discovered modes of actions for volatile organic compounds and persistent organic pollutants include the following: (i) the endocrine-, metabolism-, and signaling-disrupting chemical hypotheses; (ii) chemical-nutrient interactions and the “two-hit” hypothesis. These key hypotheses were then reviewed in the context of the steatosis adverse outcome pathway (AOP) proposed by the US Environmental Protection Agency. Summary The conceptual understanding of the contribution of environmental exposures to FLD has progressed significantly. However, because this is a new research area, more studies including mechanistic human data are required to address current knowledge gaps.
- 1 January 2019
- Published by Elsevier in Cellular Signalling
- Vol. 53, 132-139
Hepatic signalling disruption by pollutant Polychlorinated biphenyls in steatohepatitis
- 1 January 2019
- Published by Elsevier in Cellular Signalling
- Vol. 53, 132-139
Hepatic signalling disruption by pollutant Polychlorinated biphenyls in steatohepatitis