Wen-Yi Chou

The utilization of allogenic decellularized dermis graft is an emerging option in the treatment of massive tears in the rotator cuff. Our purpose is to evaluate patients undergoing superior capsular reconstruction (SCR) and the graft bridging (GB) technique using allogenic dermis graft. In addition, we aim to identify the prognostic factors that contribute to graft failure. This case–control study investigates the clinical and radiologic evaluations of patients with irreparable massive rotator cuff tear before and 12 months after the allogenic decellularized dermis graft. Our clinical evaluations include assessments of the intensity of the visual analogue scale and Constant score, both prior to and 12 months following the surgical intervention. Radiographic analysis includes Hamada classification, acromiohumeral interval, coracohumeral distance, graft integrity, and Goutallier grade on plain radiography or magnetic resonance imaging, both taken before and 12 months after the surgical intervention. A total of 24 patients were enrolled in the study, with 14 patients undergoing graft bridging procedures and the remaining patients receiving SCR. After the surgery, all patients experienced a significant improvement in various measures, including the visual analog scale, Constant score, and coracohumeral distance. The follow-up magnetic resonance imaging showed that 62.5% of the patients had a healing graft, while 37.5% had a failed graft. Moreover, patients in the graft failure group had lower visual analog scale scores, decreased acromiohumeral interval, late-stage Goutallier muscle atrophy, and higher Hamada classification compared with the graft healing group. The use of decellularized allogeneic dermis grafts in the SCR/graft bridging technique led to improvements in pain and functional outcomes. Preoperative prognostic factors for graft failure included lower preoperative pain, decreased acromiohumeral interval, Goutallier muscle atrophy (grade 3 or higher), and advanced cuff tear arthropathy (Hamada grade 3 or higher).

Background: Adolescent baseball players often experience throwing arm complaints from the repetitive activity of baseball, which can affect performance and overall well-being. More focus is needed on their psychological and social challenges in order to achieve better treatment outcomes. Purpose: To investigate changes in the health-related quality of life (HRQOL) among adolescent baseball players in Taiwan and identify the factors that influence HRQOL. Study Design: Cohort study; Level of evidence, 2. Methods: Taiwanese adolescent baseball players (12-18 years old) of all positions from junior and senior high schools were surveyed every 3 months for 1 year (starting in August 2022). Data on demographic characteristics, training volume, throwing arm injury history, and Functional Arm Scale for Throwers (FAST) scores (1 measurement of HRQOL for baseball players) were collected and analyzed using mixed-effects regression models. Results: The study included 299 adolescent baseball players (mean age, 14 years; range, 12-18 years). Pitchers and outfielders exhibited higher FAST total scores than infielders and catchers (mean ± SE, 14.74 ± 16.60 and 14.24 ± 18.76 vs 8.92 ± 9.77 and 9.52 ± 9.56, respectively; P = .027), which indicated more physical disability and psychological impact. In the mixed-effects regression model for FAST total scores, injury history (estimate for mild injury, 7.18 ± 1.25; moderate injury, 18.28 ± 3.00; severe injury, 22.94 ± 3.76 vs healthy), player position (pitcher 4.20 ± 1.97 vs infielder), and months of follow-up (estimate for 3 months, –4.86 ± 1.33; 6 months, –4.55 ± 1.48; 9 months, –4.27 ± 1.85; 12 months –5.84 ± 2.28 vs 0 months). Training volume did not significantly affect HRQOL scores ( P = .629). Conclusion: Our study demonstrated significant differences in most FAST total and subscale scores among player positions. Pitchers and outfielders exhibited higher FAST scores than the other positions, indicating more physical disability and psychological impact. Furthermore, the severity of throwing arm injury history significantly influenced FAST scores, with more severe injuries correlating with poorer outcomes. However, training volume did not significantly impact FAST scores. These data may help in future studies integrating patient-reported outcomes and HRQOL to evaluate athlete’s’ well-being beyond just physical parameters.

Background: Osteoporosis (OP) is a chronic inflammatory bone disease characterized by reduced bone structure and strength, leading to increased fracture risk. Effective therapies targeting both bone and cartilage are limited. This study compared the therapeutic effects of extracorporeal shockwave therapy (ESWT), bisphosphonate (Aclasta), and human Wharton jelly-derived mesenchymal stem cells (WJMSCs) in a rat model of OP. Methods: Female rats were assigned to four groups: Sham (no surgery or treatment), OP (bilateral ovariectomy, OVX), ESWT (OVX + ESWT on both tibias at 0.25 mJ/mm², 1500 impulses per tibia), Aclasta (OVX + zoledronic acid 0.1 mg/kg via tail vein injection), and WJMSC (OVX + 2 × 10⁶ WJMSCs). Pathological changes, bone microarchitecture (by micro-CT), serum cytokines (by ELISA), and tissue-specific molecular markers (by immunohistochemistry) were evaluated. Results: All treatments improved bone density, preserved cartilage, and modulated cytokines (IL31, IL33, VEGF, and BMP2), with Aclasta showing the greatest improvements in bone parameters and cartilage preservation. ESWT and WJMSC also demonstrated significant effects, with ESWT highlighting non-invasive chondroprotective potential. Conclusions: Aclasta provided the best overall therapeutic response, particularly in bone regeneration. However, ESWT and WJMSC also showed comparable chondroprotective effects. ESWT emerges as a promising non-invasive alternative for OP management when pharmacological or cell-based therapies are not feasible.

Background: Extracorporeal shockwave therapy (ESWT) is the primary treatment for calcific tendinitis of the shoulders, but what are the effects of clinical, sonographic, and molecular markers following ESWT in treating calcific tendinitis of the shoulder? Methods: Twenty-eight patients were categorized into radiodense and radiolucent subgroups. In addition, clinical assessments included the visual analogue scale (VAS), Constant-Murley (CM) score, American Shoulder and Elbow Surgeon (ASES) score, sonographic evaluation, and serum enzyme-linked immunosorbent assay (ELISA). The participants completed a 1-year follow-up. All data were collected before and after treatment. Results: After 1 year of follow-up, all patients showed notable improvement in VAS, CM, and ASES scores, with no significant clinical variations among the subgroups. However, the radiolucent group showed significant complete resorption and size reduction at the final follow-up. The sonographic evaluation revealed improved tissue perfusion and reduced calcification from 3 to 12 months in all patients, including those in the radiolucent group, but complete resorption of calcific deposits did not occur. The percentage of tissue perfusion was improved at 1 and 3 months after ESWT. There were no significant differences in the levels of the molecular markers interleukin-1 beta (IL-1 β) or IL-33, but the level of insulin-like growth factor 1 (IGF-1) was notably increased at 1 and 3 months post-ESWT. The BMP7 level was increased at 3 months and was then decreased significantly at 6 and 12 months. Conclusion: ESWT improved symptoms, reduced calcification, enhanced tissue perfusion, and promoted angiogenesis and BMP7 activity. In particular, it benefited radiolucent type patients with better calcification resorption. Partial resorption led to improvements in transparency, and a second ESWT session at 3 months was recommended for optimal results.

Aims: To explore the efficacy of extracorporeal shockwave therapy (ESWT) in the treatment of osteochondral defect (OCD), and its effects on the levels of transforming growth factor (TGF)-β, bone morphogenetic protein (BMP)-2, -3, -4, -5, and -7 in terms of cartilage and bone regeneration.Methods: The OCD lesion was created on the trochlear groove of left articular cartilage of femur per rat (40 rats in total). The experimental groups were Sham, OCD, and ESWT (0.25 mJ/mm², 800 impulses, 4 Hz). The animals were euthanized at 2, 4, 8, and 12 weeks post-treatment, and histopathological analysis, micro-CT scanning, and immunohistochemical staining were performed for the specimens.Results: In the histopathological analysis, the macro-morphological grading scale showed a significant increase, while the histological score and cartilage repair scale of ESWT exhibited a significant decrease compared to OCD at the 8- and 12-week timepoints. At the 12-week follow-up, ESWT exhibited a significant improvement in the volume of damaged bone compared to OCD. Furthermore, immunohistochemistry analysis revealed a significant decrease in type I collagen and a significant increase in type II collagen within the newly formed hyaline cartilage following ESWT, compared to OCD. Finally, SRY-box transcription factor 9 (SOX9), aggrecan, and TGF-β, BMP-2, -3, -4, -5, and -7 were significantly higher in ESWT than in OCD at 12 weeks.Conclusion: ESWT promoted the effect of TGF-β/BMPs, thereby modulating the production of extracellular matrix proteins and transcription factor involved in the regeneration of articular cartilage and subchondral bone in an OCD rat model.Cite this article: Bone Joint Res 2024;13(7):342–352.

Background: Nonunion of long bone fractures is a significant complication following surgical fixation, with an incidence ranging from 5 to 10%. Surgical intervention is the standard treatment for nonunions, but it may come with potential complications. Nonoperative approaches, such as Extracorporeal Shockwave Therapy (ESWT), have been advocated as alternatives. Methods: In the retrospective study conducted between January 2004 and January 2018, 91 patients who underwent ESWT for tibia or femur nonunions were included. Nonunion was defined based on radiographic criteria and clinical symptoms. The nonunion morphology was categorized as hypertrophic, oligotrophic, or atrophic. ESWT was administered using the OssaTron device in a single treatment session. Bony union was defined as the presence of a bridging callus over the fracture site with more than three-fourths of the circumference in both planes within the 12-month postoperative period. Results: The study included 91 patients, with an overall union rate of 62.6%. A higher healing rate was observed in trophic nonunion(69.9%) than in atrophic nonunion(33.3%). Multivariate analysis identified the number of surgeries, maximum fracture gap, and atrophic nonunion as independent factors influencing the risk of fracture nonunion after ESWT. The receiver operating characteristic curves were generated for these factors, providing more than one surgical intervention, and fracture gap greater than 3.94 mm as negative predictors of ESWT for long bone nonunions. Conclusion: The study’s primary findings suggest that ESWT is effective in achieving bony union for nonunions in long bones(62.6%). Despite the overall positive results, the study highlights that atrophic nonunions, larger fracture gaps of more than 3.94 mm, and multiple surgeries are associated with poorer outcomes.

Background: The clinical superiority of surgical treatment for acromioclavicular (AC) joint dislocation remains controversial. The aim of this study was to compare the clinical and radiological outcomes of the modified Phemister procedure with CC ligament augmentation using Mersilene tape to those of hook plate fixation for acute AC joint dislocation. Methods: In this study, patients who received modified Phemister surgery with CC ligament augmentation using Mersilene tape (PM group) or hook plate fixation (HK group) for acute unstable AC joint dislocation with a minimum 5-year follow-up period were retrospectively reviewed. The clinical outcomes were evaluated according to blood loss during surgery, surgical duration, visual analogue scale (VAS), Constant-Murley score (CMS), University of California at Los Angeles (UCLA) shoulder rating scale, and the occurrence of complications. Radiological outcomes were assessed from radiographs according to multiple parameters, including CC distance maintenance, acromion osteolysis, and the presence of distal clavicle osteolysis. Results: A total of 35 patients completed follow-up for more than 5 years and were analyzed in this study (mean = 74.08 months). There were 18 patients in the PM group and 17 in the HK group. The PM group exhibited similar improvement in functional outcome to the HK group. Regarding radiological outcomes, the HK group had a superior performance in terms of CC distance maintenance, of statistical significance (CCDR: 94.29 ± 7.01% versus 111.00 ± 7.69%, p < 0.001) after a one-year follow-up period. However, there were 4 cases of acromion osteolysis and 2 cases of distal clavicle osteolysis in the HK group. Conclusion: Hook plate fixation was found to be superior to the modified Phemister technique with CC ligament augmentation using Mersilene tape in terms of CC distance maintenance, but there was no significant difference in the functional outcome after 5 years of follow-up. Both surgical methods are reliable options for the treatment of acute AC joint dislocation. Modified Phemister surgery with CC ligament augmentation using Mersilene tape is a relatively lower-cost option for acute AC joint dislocation without the need of a second surgery for implant removal.

Background: Numerous studies have discussed the risk factors for shoulder and elbow injuries in high school baseball players worldwide. Purpose: To determine the risk factors for pitching-related shoulder and elbow injuries in Taiwanese high school pitchers. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Included in the study were 144 pitchers from 11 top-ranked Taiwanese high school baseball teams between 2016 and 2017 high school baseball season. The participants answered a 55-item questionnaire concerning physical characteristics, pitching activities, injury history, and off-season activities. Univariate analyses were conducted separately for participants with and those without a pitching-related injury in the 12-month study period. The chi-square test or Fisher exact test was applied to categorical variables, and the F test or t test was applied to continuous variables. A stepwise multivariate logistic regression analysis was used to identify factors related to pitching-related injuries, and those results were calculated as odds ratios (ORs). Results: Having a pitching-related injury was significantly related to the number of pitches per week in the past 12 months (OR, 1.01; P = .006), pain over the shoulder and/or elbow in the past 12 months (OR, 3.56; P = .008), pitching competitive baseball for more than 8 of the past 12 months (OR, 2.53; P = .036), throwing sliders (OR, 2.97; P = .026), and lack of participating in other over-the-shoulder activities (0.03-0.11 fewer odds; P ≤ .010). Conclusion: For elite high school pitchers in Taiwan, pitching-related shoulder and elbow injuries were related to the number of pitches per week, pitching competitive baseball for more than 8 of the past 12 months, pain over the shoulder and/or elbow in the past 12 months, throwing sliders, and a lack of participation in other sports with over-the-shoulder activities.

Conservative treatments for early osteoarthritis (OA) of the knee included the use of non-steroid anti-inflammatory drugs (NSAIDs) and intra-articular hyaluronic acid (HA) injection. Recently, several animal studies reported that extracorporeal shockwave therapy (ESWT) demonstrated chondroprotective effects on knee OA. The present study compared the efficacy of oral NSAIDs, HA injection, and noninvasive ESWT for early OA of the knee. Forty-five patients with early knee OA were randomized into three groups. NSAIDs group received celecoxib 200 mg daily for 3 weeks. HA group received intra-articular injection of HA once a week for 3 weeks. ESWT group received ESWT for 3 sessions at bi-weekly interval. All patients were followed up for one year. Evaluations included the visual analogue scale (VAS) score, serum enzyme-linked immunosorbent assay (ELISA), plain radiography, dual-energy X-ray absorptiometry (DEXA), and magnetic resonance imaging (MRI). In addition, the functional scores were performed including, WOMAC (Western Ontario and McMaster Universities Arthritis Index) score, KOOS (knee injury and osteoarthritis outcome) score, and IKDC (International Knee Documentation Committee) score. All three groups showed significant improvement in VAS and functional scores as well as in the collected one-year follow-up data after treatments. ESWT group had better pain relief than NSAIDs and HA groups. ESWT group had better therapeutic effects in the functional scores than NSAIDs and HA groups. The bone mineral density (BMD) of proximal tibia is significantly increased after ESWT than others. In the serum ELISA, ESWT inhibited the expression of COMP in knee OA patients as compared with NSAIDs and HA groups. The parameters of MRI showed no significant differences between three groups after treatments. ESWT and intra-articular HA injection showed comparable results than NSAIDs. ESWT was superior in pain relief than HA and NSAIDs. The results demonstrated that ESWT was an effective and alternative therapy than HA and NSAIDs for early osteoarthritis of the knees.