Petra Hamerlik

Supplementary Figure 1 shows an overview of ITCC-P4 PDX engraftment success rates and multi-omics data availability

Supplementary Figure S2 shows methylation- and transcriptome-based analyses of ITCC-P4 PDX models

Supplementary Figure S3 displays a comparison of driver mutation profiles between ITCC-P4 PDX models and matched patient tumors.

Supplementary Figure S4 shows the genomic characterization of ITCC-P4 PDX models and matched patient tumors.

Supplementary Figure S5 shows genomic fidelity between ITCC-P4 PDX models and matched patient tumors.

Supplementary Figure S7 shows Clonal evolution analyses of sequential PDX models.

Supplementary Figure S6 displays the methylation-based tSNE analysis of serial PDX models across pediatric cancer entities.

Supplementary Table 1: Table resuming the clinical, xenograft and data details for the PDX models in the ITCC-P4 cohort.

Supplementary Table 2:List of ITCC-P4 and reference samples included in DNA methylation analyses; PDX-tumor distance Manhattan scores; Methylation-inferred purity scores.