Abbas Ahmadi

Quantification of tissue parameters using MRI is emerging as a powerful tool in clinical diagnosis and research studies. The need for multiple long scans with different acquisition parameters prohibits quantitative MRI from reaching widespread adoption in routine clinical and research exams. Accelerated parameter mapping techniques leverage parallel imaging, signal modelling and deep learning to offer more practical quantitative MRI acquisitions. However, the achievable acceleration and the quality of maps are often limited. Joint MAPLE is a recent state-of-the-art multi-parametric and scan-specific parameter mapping technique with promising performance at high acceleration rates. It synergistically combines parallel imaging, model-based and machine learning approaches for joint mapping of T1, T2*, proton density and the field inhomogeneity. However, Joint MAPLE suffers from prohibitively long reconstruction time to estimate the maps from a multi-echo, multi-flip angle (MEMFA) dataset at high resolution in a scan-specific manner. In this work, we propose a faster version of Joint MAPLE which retains the mapping performance of the original version. Coil compression, random slice selection, parameter-specific learning rates and transfer learning are synergistically combined in the proposed framework. It speeds-up the reconstruction time up to 700 times than the original version and processes a whole-brain MEMFA dataset in 21 minutes on average, which originally requires ~260 hours for Joint MAPLE. The mapping performance of the proposed framework is ~2-fold better than the standard and the state-of-the-art evaluated reconstruction techniques on average in terms of the root mean squared error.

Purpose: Quantitative MRI finds important applications in clinical and research studies. However, it is encoding intensive and may suffer from prohibitively long scan times. Accelerated MR parameter mapping techniques have been developed to help address these challenges. Here, an accelerated joint T₁, , frequency and proton density mapping technique with scan‐specific self‐supervised network reconstruction is proposed to synergistically combine parallel imaging, model‐based, and deep learning approaches to speed up parameter mapping.Methods: Proposed framework, Joint MAPLE, includes parallel imaging, signal modeling, and data consistency blocks which are optimized jointly in a combined loss function. A scan‐specific self‐supervised reconstruction is embedded into the framework, which takes advantage of multi‐contrast data from a multi‐echo, multi‐flip angle, gradient echo acquisition.Results: In comparison with parallel reconstruction techniques powered by low‐rank methods, emerging scan specific networks, and model‐based estimation approaches, the proposed framework reduces the reconstruction error in parameter maps by approximately two‐fold on average at acceleration rates as high as R = 16 with uniform sampling. It can outperform evaluated parallel reconstruction techniques up to four‐fold on average in the presence of challenging sub‐sampling masks. It is observed that Joint MAPLE performs well at extreme acceleration rates of R = 25 and R = 36 with error values less than 20%.Conclusion: Joint MAPLE enables higher fidelity parameter estimation at high acceleration rates by synergistically combining parallel imaging and model‐based parameter mapping and exploiting multi‐echo, multi‐flip angle datasets. Utilizing a scan‐specific self‐supervised reconstruction obviates the need for large data sets for training while improving the parameter estimation ability.

Three-dimensional (3D) image reconstruction of tumors has been one of the most effective techniques for accurately visualizing tumor structures and treatment with high resolution, which requires a set of two-dimensional medical images such as CT slices. In this paper we propose a novel method based on generative adversarial networks (GANs) for 3D lung tumor reconstruction by CT images. The proposed method consists of three stages: lung segmentation, tumor segmentation and 3D lung tumor reconstruction. Lung and tumor segmentation are performed using snake optimization and Gustafson-Kessel (GK) clustering. In the 3D reconstruction part first, features are extracted using the pre-trained VGG model from the tumors that detected in 2D CT slices. Then, a sequence of extracted features is fed into an LSTM to output compressed features. Finally, the compressed feature is used as input for GAN, where the generator is responsible for high-level reconstructing the 3D image of the lung tumor. The main novelty of this paper is the use of GAN to reconstruct a 3D lung tumor model for the first time, to the best of our knowledge. Also, we used knowledge transfer to extract features from 2D images to speed up the training process. The results obtained from the proposed model on the LUNA dataset showed better results than state of the art. According to HD and ED metrics, the proposed method has the lowest values ​​of 3.02 and 1.06, respectively, as compared to those of other methods. The experimental results show that the proposed method performs better than previous similar methods and it is useful to help practitioners in the treatment process.