Bin Zhang

Three discrete dinuclear silver(I) halide complexes of the formula [Ag2X2L2] (X = I (1), Br (2), Cl (3)) have been synthesized using a novel benzothiadiazole-functionalized bisphosphine ligand. Crystallographic analysis reveals that the trigonal planar geometry around the silver centers is effectively stabilized and rigidified by intramolecular π–π interactions between the benzothiadiazole moieties, especially for 1 and 2. At room temperature, all complexes exhibit fluorescence in both the solid state and solution. Notably, complex 1 in solution displays intense yellow emission (CIE1931: 0.443, 0.538) with a high photoluminescence quantum yield (PLQY) of 47% and a lifetime of 26.4 ns. Furthermore, doping complex 1 into a PMMA matrix (5 wt%) yields green emission (CIE1931: 0.270, 0.525) with an enhanced PLQY of 81%. These findings highlight the value of intramolecular π–π interactions in constructing efficient luminescent materials based on simple discrete Ag(I) complexes.

Computationally, doping of the Se/N radical p -NCC ₆ F ₄ CNSeSeN (2) into the organic magnet, p -NCC ₆ F ₄ CNSSN (1β) should enhance the magnetic ordering temperature but, experimentally, doping of 1 with 2 from solution affords the alternative polymorph, 1α.

Three-coordinate mononuclear copper(I) halide complexes (1 (I) and 2 (Br)) that bear a novel rigid diphosphine ligand derived from a benzimidazole skeleton were prepared and characterized. Structural analyses of 1 and 2 reveal that the rigidity of the functionalized diphosphine ligand leads to weak Cu⋯π_imidazole interactions. Solid state luminescence studies show that the existence of cation–π interactions and the heavy atom effect facilitate orange-red emission (630 nm for 1 and 615 nm for 2) with high photoluminescence quantum yields (65% and 72% for 1 and 2, respectively) and decay times of a few tenths of microseconds. The combination of experimental results and quantum-chemical calculations reasonably reveals that the emission origin is assigned to TADF-assisted phosphorescence based on (metal + halide) to ligand transitions. This systematic study demonstrates that the introduction of a functional π-conjugated bridging moiety between the two P atoms in the diphosphine ligands is a promising strategy for developing new structures with high luminescence performance.

MicroRNAs (miRNAs/miRs) function as key regulators in breast cancer (BC). The present study aimed to verify the function and molecular regulation of miR‑337‑3p in BC cells. Bioinformatics analysis was performed to screen key genes and miRNAs associated with BC. Reverse transcription‑quantitative PCR and western blot analyses were performed to detect RNA and protein expression levels. Cell Counting Kit‑8, BrdU and cell adhesion assays, and flow cytometric analysis were performed to assess the biological behaviors of BC cells. The dual‑luciferase reporter, RNA pull‑down assays, and Pearson's correlation analysis were performed to determine the association between miRNAs and mRNAs. Bioinformatics analysis revealed that miR‑337‑3p and cyclin‑dependent kinase 1 (CDK1) acted as key regulators in BC. In addition, miR‑337‑3p was expressed at low levels in BC cells and tissues, which suppressed BC progression. CDK1 expression was upregulated in BC cells and tissues, which was associated with increased cell proliferation and adhesion, as well as decreased apoptosis in BC. Notably, miR‑337‑3p targeted CDK1 to inhibit BC cell progression. Taken together, the results of the present study suggest that miR‑337‑3p plays a tumor‑suppressive role in BC by targeting CDK1.