Lina Ma

Background: The triglyceride-glucose (TyG) index is a surrogate marker of insulin resistance, implicated in cognitive decline and Alzheimer's disease (AD), but whether long-term TyG exposure is associated with cognitive health remains unclear. Objective: To examine whether cumulative TyG index is associated with cognitive performance, mild cognitive impairment (MCI), and follow-up cognitive performance in two community-based cohorts. Methods: We analyzed adults aged ≥60 years in the Beijing Disability Risk and Ageing Monitoring Study (BEAM) and ≥45 years in the China Health and Retirement Longitudinal Study (CHARLS). Cumulative TyG was estimated from four annual measurements (2020–2023) in BEAM and two measurements (2012 and 2015) in CHARLS. Cognitive outcomes were assessed in 2023 and 2015, respectively. Multivariable linear and logistic regression models were applied. Results: A total of 3857 participants were included, comprising 585 participants from BEAM (mean age 73.0 ± 5.1 years; 64.4% women) and 3272 participants from CHARLS (mean age 58.9 ± 8.8 years; 51.4% women). Higher cumulative TyG was associated with higher global cognitive scores in BEAM ( β =0.11, 95% CI 0.02–0.20, p = 0.013) and CHARLS ( β =0.13, 95% CI 0.05–0.23, p = 0.003). Higher cumulative TyG was also associated with lower odds of MCI (BEAM: OR = 0.85, 95% CI 0.73–0.98, p = 0.028; CHARLS: OR = 0.92, 95% CI 0.86–0.99, p = 0.041). However, cumulative TyG was not associated with follow-up cognitive performance after adjustment for baseline cognition. Conclusions: Cumulative TyG was modestly associated with higher cognitive performance and lower odds of MCI in cross-sectional analyses, but not with follow-up cognitive performance.

Background: With the progression of population aging and the growing demands for health management among older adults, identifying factors influencing mortality risk is of great significance. In particular, parameters related to blood lipids and body composition warrant in-depth investigation. This study aims to examine the association between the triglyceride-total cholesterol-body weight index (TCBI) and mortality among Chinese older adults. Methods: Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS). Participants enrolled in the 2011 baseline survey were followed until 2020, yielding up to 9 years of follow-up. TCBI was measured at baseline enrollment in 2011 when participants were first recruited into the cohort study, and was calculated and categorized into quartiles (Q1–Q4). Cox proportional hazards models were used to assess the association between TCBI and mortality. Restricted cubic splines with 4 knots were employed to explore potential non-linear associations. Sensitivity analysis was performed to examine the robustness of the findings, including re-running models. Results: A total of 4343 individuals aged 67.8 ± 6.4 years were included in the analysis. Over the follow-up period (median 105.8 months), 150 (3.5%) deaths were documented. As TCBI values increased, the likelihood of mortality exhibited a progressive decline ( P for trend = 0.001). After multivariable adjustment for age, sex, educational attainment, smoking status, drinking status, cardiovascular disease, diabetes, hypertension, and dyslipidemia, the highest TCBI quartile (Q4) was associated with a 61% reduction in mortality risk compared with the lowest quartile (Q1) (adjusted hazard ratio 0.39, 95% confidence interval 0.23–0.68). A linear inverse relationship between TCBI and mortality was confirmed by restricted cubic spline analysis ( P for nonlinear = 0.480). Sensitivity analyses yielded consistent results, supporting the robustness of the findings. Conclusion: Elevated TCBI levels are associated with a reduced risk of all-cause mortality among Chinese older adults. These findings suggest that TCBI may serve as a practical and valuable biomarker for stratifying mortality risk in geriatric health assessments.

Held on August 17, 2025 in Guangzhou, the inaugural International Exchange Forum of the Chinese Geriatrics Society marked a significant milestone in advancing geroscience and fostering global collaboration in China. The forum brought together leading international experts and emerging Chinese researchers to present the latest advances in aging research. Presentations covered various topics, such as musculoskeletal aging (mitochondrial dysfunction, muscle-bone communication, and exosome-mediated mechanisms in sarcopenia and osteoporosis), cardiovascular aging (tyrosine kinase inhibitor- and anthracycline-induced cardiotoxicity), metabolic regulation (sarcopenic obesity and the gut-muscle axis), neurodegenerative interfaces (androgen-mediated monocyte-microglia interactions in Alzheimer’s disease), and geriatric assessment (muscle-specific strength, intrinsic capacity, and gait biomarkers). There was a particular focus on novel mechanistic insights, such as RNA epitranscriptomics, mitochondrial homeostasis, and inter-organ communication, as well as on strategies for early risk prediction, intervention, and personalized management. The forum also emphasized the importance of addressing sex-specific differences and translating basic discoveries into clinical applications. As a platform designed to promote academic dialogue and collaboration, the forum successfully brought together the Chinese and global geroscience communities. It emphasized the necessity of multidisciplinary and international efforts to address the challenges posed by population aging. Moving forward, sustained partnerships, data sharing, and capacity-building initiatives will be essential to accelerating the development of evidence-based, scalable solutions for healthy aging in China and beyond. This event sets a precedent for future exchanges that integrate scientific innovation with clinical practice to improve the health and quality of life of aging populations worldwide.

Background: The Charlson Comorbidity Index (CCI) is widely used to assess comorbidity burden, its prognostic role in patients undergoing percutaneous coronary intervention (PCI) remains underexplored. This study aimed to investigate the impact of CCI on in-hospital adverse events and long-term major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with coronary artery disease (CAD) treated with PCI. Methods: A total of 572 consecutive CAD patients who underwent PCI between October 2016 and October 2020 were included. Patients were divided into low (CCI ≤ 4, n = 453) and high (CCI > 4, n = 119) comorbidity burden groups. Clinical characteristics, in-hospital adverse events, and long-term MACCEs were compared. Multivariate logistic regression and Cox proportional hazards models were used to identify independent predictors of outcomes. Results: Compared to the low-CCI group, patients in the high-CCI group were older, more frequently male, and had higher rates of diabetes, left main CAD, and multivessel disease (all p < 0.05). In-hospital adverse events were significantly more common in the high-CCI group (13.4% vs 2.0%, p < 0.01). CCI was an independent predictor of in-hospital events (OR = 3.13; 95% CI: 1.40– 7.02). During a median follow-up of five years, the high-CCI group had a significantly higher incidence of MACCEs (51.3% vs 6.2%; HR = 2.72; 95% CI: 2.25– 3.30, p < 0.01). Conclusion: CCI is a significant and independent predictor of both in-hospital and long-term adverse outcomes in CAD patients undergoing PCI.

Background: As China undergoes a demographic transition towards an aging society, the prevalence and incidence of age-related disabilities, Alzheimer's disease, and various geriatric syndromes are steadily rising. Objective: The China Healthy Aging Cohort Study (China-Aging) aims to investigate the prevalence and associated risk factors of disability and cognitive impairment, and to develop predictive models for these conditions by combining traditional risk factors with artificial intelligence-derived metrics (such as gait, speech, vision, etc.). Methods: The China-Aging cohort consists of community-dwelling participants aged 60 years and older from Beijing, Hangzhou, Shenzhen, and Haikou. The baseline recruitment was from May 16, 2022 to March 19, 2025, with study participants primarily from urban areas. Follow-up assessment of the cohort will occur every 1–3 years from the baseline. Results: Among 6283 participants who completed the baseline evaluation (mean age 70.6 years, SD 6.3), 3775 (60.1%) were women. The overall prevalence of disability, cognitive impairment, frailty, depression, and sarcopenia were 17.8%, 18.5%, 5.9%, 7.1%, and 5.7%, respectively. The prevalence of disability in the Beijing cohort was higher than in other cohorts (Beijing: 35.6%, Hangzhou: 6.5%, Shenzhen: 6.8%, Haikou: 10.9%) and the prevalence of cognitive impairment in the Haikou cohort was higher than in other cohorts (Beijing: 9.5%, Hangzhou: 7.9%, Shenzhen: 16.2%, Haikou: 45.5%). Conclusions: The prevalence of disability and cognitive impairment is relatively high, and notable regional difference exists in China. China-Aging cohort provides crucial evidence for the precise prevention and management of disability, cognitive impairment, and other geriatric syndromes in promoting active and healthy aging.