Song-Yi Park

Pairwise correlation coefficients between each dietary score examined in analyses.

Associations of dietary scores (per 1-SD increase) with prostate cancer risk among Japanese Americans in the MEC.

Associations of dietary scores (per 1-SD increase) with prostate cancer risk among Native Hawaiians in the MEC.

Associations of dietary scores (per 1-SD increase) with prostate cancer risk among Latinos in the MEC.

Associations of dietary scores (per 1-SD increase) with prostate cancer among African Americans in the MEC.

Distribution of dietary scores by PSA screening history in the MEC.

Associations of dietary scores (per 1-SD increase) with prostate cancer among men with PSA screening information in the MEC (N = 62,151), with and without adjustment for PSA screening history.

Associations of dietary scores (per 1-SD increase) with prostate cancer risk among Whites in the MEC.

Background:Healthy dietary patterns have been linked to reduced cancer risk, but evidence for prostate cancer remains inconsistent, especially across diverse populations.Methods:In the Multiethnic Cohort study, we examined associations between 11 diet scores and prostate cancer risk among 79,930 men (White, African American, Japanese American, Latino, or Native Hawaiian). HRs and 95% confidence intervals (CI) per 1 SD increase in each score were estimated from Cox proportional hazards models for total prostate cancer and by grade, stage, and aggressiveness. Analyses were conducted overall and within racial/ethnic groups. A significance threshold of P < 0.003 was used to adjust for multiple testing.Results:Over a mean follow-up of 18.8 years, 9,759 prostate cancer cases were identified. No significant associations were observed in the hypothesized direction between dietary scores and prostate cancer risk in the overall population. However, among African Americans, higher Dietary Approaches to Stop Hypertension scores were suggestively associated with a 14% lower risk of advanced prostate cancer (95% CI, 0.77–0.98; P = 0.02). Among Japanese Americans, higher Empirical Dietary Index for Insulin Resistance scores were linked to an increased risk of low-grade (HR = 1.09; 95% CI, 1.02–1.17; P = 0.01) and nonaggressive prostate cancer (HR = 1.10; 95% CI, 1.02–1.19; P = 0.02).Conclusions:Although no strong associations were found overall, specific dietary patterns may influence prostate cancer risk differently by race/ethnicity and tumor subtype, warranting further investigation in large and diverse populations.Impact:These findings highlight the need for future studies to explore disease-specific and culturally informed dietary patterns that may inform prostate cancer prevention across diverse populations.

Background and ObjectivesPlant-based diets have been linked to slower cognitive decline, but data on long-term dietary changes and from diverse populations are limited. The primary aim of this stud...