Michelle Locke

"Introduction: Periprosthetic breast implant infections are a well-known but devastating complication of breast reconstruction, occurring in up to 35 per cent of patients postoperatively. Historically, surgical washout and explantation was common practice to control infection, often sacrificing the reconstruction. Methods: After successfully using negative-pressure wound therapy with instillation (Veraflo, Intermed, Auckland) on lower leg wounds, we transferred the use of this technology to infected breast pockets. Results: In the first year using NPWTi, our department managed seven patients (8 breast reconstructions) presenting with breast device infection at an average of 15.3 days postoperatively. The average length of stay for treatment was 7.4 days with 2.5 operations over this period. Four patients had attempted salvage of their reconstructive pocket and all were discharged with a breast expander in situ. Conclusion: Attempted salvage using negative-pressure wound therapy with instillation may improve rates of reconstruction salvage after periprosthetic infection. We present our current management algorithm for periprosthetic infections."

Among green tea catechins, epigallocatechin gallate (EGCG) is the most abundant and has the highest biological activities. This study aims to develop and statistically optimise an EGCG-loaded niosomal system to overcome the cutaneous barriers and provide an antioxidant effect. EGCG-niosomes were prepared by thin film hydration method and statistically optimised. The niosomes were characterised for size, zeta potential, morphology and entrapment efficiency. Ex vivo permeation and deposition studies were conducted using full-thickness human skin. Cell viability, lipid peroxidation, antioxidant enzyme activities after UVA-irradiation and cellular uptake were determined. The optimised niosomes were spherical and had a relatively uniform size of 235.4 ± 15.64 nm, with a zeta potential of −45.2 ± 0.03 mV and an EE of 53.05 ± 4.46%. The niosomes effectively prolonged drug release and demonstrated much greater skin penetration and deposition than free EGCG. They also increased cell survival after UVA-irradiation, reduced lipid peroxidation, and increased the antioxidant enzymes’ activities in human dermal fibroblasts (Fbs) compared to free EGCG. Finally, the uptake of niosomes was via energy-dependent endocytosis. The optimised niosomes have the potential to be used as a dermal carrier for antioxidants and other therapeutic compounds in the pharmaceutical and cosmetic industries.

New Zealand's most active volcano, Whakaari White Island was a common tourist attraction prior to its eruption on 9 ^th December 2019. At the time of the eruption, there were 47 people on the island from three tour groups. 39 people survived the initial eruption and were extracted. 31 entered into the New Zealand National Burn Service across four hospitals. The median age of the patients treated at the National Burn Centre was 45.5 years (range: 14 − 67 years) and median total body surface area burn was 49.5% (range: 9% - 90%). The three month survival of this eruptive event was 55%, which subsequently fell to an overall rate of 53% following one late death of an early survivor after repatriation home. Of the patients who survived the initial eruption for long enough to be admitted to the National Burn Service, the overall survival rate was 71% at three months. We describe 12 lessons we have learnt from our management of the survivors. The key surgical lessons among these are: The injuring mechanism combined ballistic trauma, thermal and acidic burn components, with the acid component being the most problematic and urgent for management. Volcanic ash burns result in on-going burn depth progression, deep underlying tissue damage and significant metabolic instability. Early skin grafting was not successful in many cases. Reconstructive strategy needed adjusting to cope with the high operative demand and limited donor sites in all patients. Protect yourself from potential dangers with additional personal protective equipment (PPE) in an unfamiliar setting.

Introduction: On 9 December 2019, Whakaari White Island erupted while 47 people were on the island. Thirty‐one people were subsequently hospitalized. Fourteen volcanic burn victims were managed at the National Burns Centre at Middlemore Hospital. Between December 2019 and March 2020 these patients required 124 procedures in theatre, using 23 709 operative minutes. Elective surgical lists were cancelled to fulfil this demand for acute operating theatre time and theatre staff.Objectives: To quantify the elective surgical resource lost in the aftermath of the Whakaari White Island eruption by surgical specialty.Methods: A data set listing all surgical procedures undertaken within Counties Manukau District Health Board during the period 1 December 2019–1 March 2020 and the corresponding months from the preceding 3 years was analysed. Sum operating time and procedures post‐Whakaari were compared with the average of the prior 3 years to quantify loss in resource.Results: In the 3 months post‐Whakaari, 698 fewer elective operations were completed across all surgical specialties than the average of the previous 3 years, a decrease of 26.3%. All major surgical specialties except urology showed an absolute decrease in elective procedures completed. The most significant decrease was the 59.1% (533 procedures) loss in plastic surgery elective procedures, with no sign of recovery by March 2021.Conclusions: The plastic surgery department was the worst affected by the Whakaari disaster. Overall elective surgical delivery within Counties Manukau was substantially impacted, and would not yet recover by the time of the national COVID‐19 lockdown in March 2020.

Michelle B Locke, MBChB, MD, FRACS; Book Review of: Shaping the Breast: A Comprehensive Approach in Augmentation, Revision, and Reconstruction, Aesthetic Surger

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) was first recognized by the World Health Organization in 2016, but cases were reported by plastics surgeons far earlier.¹ BIA-ALCL is a monoclonal T-cell lymphoma in which the malignant cells are CD30 positive and anaplastic lymphoma kinase negative. Typical presentation of BIA-ALCL is with a late (>1 year from implantation) peri-implant seroma, although other presentations such as a mass or lymph node involvement can occur. Early diagnosis of seroma-only forms of BIA-ALCL are associated with a very good prognosis compared with poorer prognosis from nodal forms.^2,3 Therefore, early diagnosis of the disease and prompt, complete surgical management remain the mainstay of treatment for BIA-ALCL.

On December 9, 2019, Whakaari/White Island volcano in New Zealand erupted with 47 people on the island. Thirty-one people survived long enough to enter the New Zealand National Burn network—13 were repatriated to Australia within 72 hours and 14 of the remaining 18 were treated at the National Burn Center at Middlemore Hospital in Auckland. Our department has previously published a model to calculate the total operative requirements for any given burn surface area for the first 4 weeks of burn treatment. From this model, we calculated the predicted surgical time and operative visit requirements for each patient and compared this to their actual requirements. Actual requirements were also recorded beyond 4 weeks until discharge. Results show that the average variance for operative minutes was significantly above predicted with both the full-thickness burn model (average variance 3.24) and the electrical burn model (average variance 2.65). There was a wide range in both cases (0.54–6.17 and 0.44–5.06, respectively). There was less variance from predicted values of operative visits required than operative minutes (mean: 1.58; range 0.9–3.02). Overall, the values for patients with smaller burns showed the greatest variability from predictions with regard to the total number of operative visits during the first 4 weeks of care. Additionally, patients with burn size greater than 50% TBSA required significant theater access beyond 4 weeks. Analysis of these findings will assist with future planning in both disaster and non-disaster settings in the provision of burn care.