Luigi Laino

Article: Congenital sialoblastoma in a newborn: diagnostic challenge of a rare entity - Minerva Dental and Oral Science 2021 Apr 30 - Minerva Medica - Journals

Prisco R, et al. J Adv Prosthodont. 2021 Dec;13(6):343-350. https://doi.org/10.4047/jap.2021.13.6.343

In the present paper, the author aims at laying the foundations of a symbolics of technical gesture, according to the thesis that symbolic faculty is another face of the technological one, and that they are both in truth two sides of the same coin. Accordingly, the author suggests to rename the whole dimension as “meta-environmentality”. The analysis is carried out on the basis of a specific comparison between Cassirer’s definition of “animal symbolicum” and its scientific consistence in the light of modern palaeontology. “Animal symbolicum” is here compared with Leroi-Gourhan’s homo technologicus, and Cassirer’s ideas on human identity tested starting from paleoanthropological data. The result of the inquiry lead us to recognize the urgency of integrating Cassirer’s argument with the primacy of the technological capacity, but a deep analysis of the characterizing attributes of the latter compels us to uphold the symbolic attitude of the technological dimension. The author then sketches a basic description ofthe guidelines of a symbolic theory of technology (especially §§ 6-7), and tries to show how the basic elements of such an approach were familiar both to Cassirer and Leroi-Gourhan. As a consequence of the whole theory, the author elaborates a chronological analysis of human identity, whose basic result is the determination of the future as main temporal dimension of human acting.

Background. Lichen sclerosus (LS) is an autoimmune inflammatory skin disease that leads to tissue sclerosis. Actually, the first-line treatment consists of local steroid as clobetasol propionate (CP). Polydeoxyribonucleotide (PDRN) has demonstrated anti-inflammatory effects through the reduction of cytokine production and growth stimulation of fibroblast. Objective. To evaluate the efficacy of intradermal administration of PDRN in male patients suffering from genital lichen sclerosus in addition to topical 0.05% CP, as compared to administering 0.05% CP without PDRN injection. Patients/Methods. A group of male patients ( = 28; aged 25 to 65) suffering from LS were observed during topical therapy or subdermal in addition to topical therapy. Disease activity at baseline was evaluated on Investigators Global Assessment (IGA) and the Dermatology Life Quality Index (DLQI). We used polydeoxyribonucleotide in a commercial preparation for human use and a topical CP emulsion. Results. After therapy, in all group A patients there has been a regression of most of clinical pathological signs, while there has been a moderate improvement in all group B patients. Conclusions. On site intradermal administration of PDRN, associated with CP 0.05% cream, seemed to be associated with a clinical improvement of lichen sclerosus better than CP used in single therapy.