Liyuan Sun

Background: Colorectal cancer (CRC) is a highly prevalent malignant tumor in China. Patients often experience negative emotions due to disease- and treatment-related stress, which impairs their ability to self-manage the illness. Benefit finding (BF) can improve patients’quality of life through cognitive restructuring. Cognitive Behavioral Stress Management (CBSM) has been proven to exert positive intervention effects on breast cancer patients, but relevant research on its application in Chinese CRC patients and its impact on their BF, quality of life and self-management ability remains scarce. Objectives: The study aimed at evaluating the effectiveness of the intervention programme based on CBSM model on benefit finding, self-management ability, and quality of life among postoperative CRC patients. Methods: A single-center, non-randomized controlled trial (non-RCT) time series study was conducted among 72 CRC patients. They were divided into an intervention group (n = 36) and a control group (n = 36). The Benefit Finding Scale (BFS), Cancer Patient Self-management Assessment Scale (CPSAS), and Cancer Rehabilitation Evaluation System-Short Form (CARES-SF) scales were used to assess BF level, self-management ability, and quality of life, respectively. The control group received routine care, while the intervention group received an 8-week CBSM-based psychological intervention in addition to routine care. Baseline data were collected before the intervention, and post-test assessments were carried out at 1 and 3 months after the intervention. Results: Of the 72 enrolled postoperative CRC patients, 67 (93.1%) completed the study, with an overall dropout rate of 6.94%. At 1 month (T1) and 3 months (T2) post-intervention, the intervention group had significantly higher total BF scores than the control group (T1: P = 0.001, Cohen’s d = 0.57; T2: P < 0.001, Cohen’s d = 0.63). Total CPSAS scores in the intervention group were significantly higher than those in the control group at T1 and T2 (T1: P = 0.007, Cohen’s d = 0.48; T2: P < 0.001, Cohen’s d = 0.66), though no significant between-group differences were observed in the dimensions of communication with medical staff and information management (all P > 0.05). While total CARES-SF scores (indicating fewer health-related issues when lower) in the intervention group were lower than those in the control group at T1 and T2, no statistically significant between-group differences were found (all P > 0.05). Correlation analyses in the intervention group showed a possible positive correlation between BF and self-management ability scores at T0, T1, and T2 (r = 0.706, 0.689, 0.551; all P < 0.001). BF scores were negatively correlated with CARES-SF scores at T0 and T2 (r = −0.295, −0.449; all P < 0.05). Self-management ability scores were negatively correlated with CARES-SF scores at T1 (r = −0.525, P < 0.05). Conclusion: CBSM-based psychological intervention can effectively enhance BF levels, promote self-management ability, and improve health-related issues in postoperative CRC patients. Moreover, a mutually reinforcing and synergistic relationship exists among these three dimensions. Trial registration: ClinicalTrials.gov ChiCTR2400092570

The study aimed to (1) investigate the levels and dynamic changes of benefit finding (BF) in gynecological cancer patients at baseline (T0), 3-month follow-up (T1), and 6-month follow-up (T2); (2) To explore the latent trajectory classes of BF using a latent class growth model; (3) To examine the dynamic relationship between BF trajectory classes, self-management efficacy, and social support. A longitudinal study. At the initial survey, participants completed questionnaires including a general demographic survey, the Chinese version of the benefit finding scale, cancer self-management efficacy scale, and social support rating scale. Follow-up data, excluding the general demographic survey, were collected at the 3 and 6 month. Statistical analyses was performed using SPSS 29.0 and Mplus 8.3. (1) The BF levels among gynecological cancer patients were moderate within the 6-month follow-up period, showing an increasing trend over time. (2) Three BF trajectory groups were identified: high stable growth group (41.1%), moderate stable growth group (45.6%), and a low continuous growth group (13.3%). (3) A dynamic relationship was observed between BF trajectory classes, self-management efficacy, and social support: patients in the high stable growth group showed continuous increases in self-management efficacy and social support over time, maintaining high levels; patients in the low continuous growth group experienced significant growth in social support. Overall, BF in gynecological cancer patients remained at a moderate level during the 6-month follow-up, showing an upward trend over time. There was heterogeneity in BF trajectories, and the trajectory categories of BF were dynamically related to self-management efficacy and social support. This study provides that latent trajectory classes of benefit finding, self-management efficacy, and social support in gynecological cancer patients. It can be used for the identification of patients with moderate to low levels of BF. The findings suggest that healthcare providers should tailor interventions based on the patient’s stage and trajectory group to better understand and meet psychological needs, alleviate negative emotions, and improve quality of life. This study is reported using the STROBE guidelines. No patient or public engagement.

Purpose: This study aimed to investigate the relationships among benefit finding (BF), self-management efficacy, and social support in patients with gynecologic cancers. Methods: A total of 180 patients with gynecological cancer were selected using a convenience sampling methodology from Maternal and Child Health Hospital in Shenzhen, China. The data collection tools included sociodemographic and disease-related information, the Chinese Version of the Benefit Finding Scale (BFS), the Chinese Self-Management Efficacy Scale for Cancer Patients (C-SUPPH), and the Social Support Rating Scale (SSRS). Data analysis involved descriptive statistics, independent-samples t-tests, one-way ANOVA, Pearson correlation analysis, and hierarchical multiple regression. The SPSS 29.0 and the PROCESS 4.2 macro were used to validate the mediating effects. Results: BF was positively correlated with social support (r = 0.235, P < 0.01) and self-management efficacy (r = 0.453, P < 0.01). Social support also showed a correlation with self-management efficacy (r = 0.268, P < 0.01). BF partially mediated the relationship between social support and self-management efficacy, accounting for 36.28% of the total effect. Conclusion: Self-management efficacy in patients with gynecological cancers is at a moderate level. Social support indirectly influences self-management efficacy through BF. Enhancing BF could serve as an effective strategy to improve self-management efficacy in this patient population.

Objective This study aims to explore and investigate the positive experiences and the benefit finding among family caregivers of patients with chronic obstructive pulmonary disease (COPD) during the caregiving process. Design A semi-structured interview was conducted with eight caregivers of individuals diagnosed with COPD, employing a phenomenological approach typical of qualitative research. The interview data were analysed using the Colaizzi’s 7-step method, which facilitated a systematic examination, summarisation and identification of themes within the data. Setting Interviews were conducted face-to-face or over the phone. Participants This study recruited family caregivers of patients with COPD at the Department of Respiratory Medicine, Shenzhen University General Hospital, from June 2024 to September 2024. Results The research identified four principal themes related to benefit finding among caregivers: enhancements in personal cognition and capabilities; the emergence and importance of health-related behaviours; acknowledgment of the significance of social support and caregiving; and the cultivation of rational perception and cognitive processes. Analysis of the interview data indicated that participants experienced substantial positive transformations. Conclusions Caregivers of individuals diagnosed with COPD can find positive aspects associated with their caregiving roles. It is crucial for healthcare providers to actively harness the potential benefits and strengths that emerge from the process of benefit finding among caregivers. By supporting caregivers in maintaining their physical and mental well-being, medical staff can significantly enhance the overall quality of care provided to patients

Objective: This study aimed to develop Benefit Finding intervention protocols for colorectal cancer patients on psychological management in China. Methods: We created an initial draft of such a protocol through a comprehensive literature review and group discussions. A two-round Delphi study via WeChat correspondence was conducted, with a group of 14 Chinese experts. Experts rated and scored the importance of indicators on a five-point Likert scale. Results: The response rates for two rounds both were 100%(n=14), with an authority coefficient of 0.86. The mean value assigned to the importance of the items ranged from 4.07 to 5.00, with coefficients of variation between 0.00 and 0.17; the Kendall coefficient was 0.214 (P<0.05). Ultimately, we established an index system comprising 8 primary items, with respective weights of 0.133, 0.131, 0.122, 0.116, 0.129, 0.122, 0.124, and 0.124. Additionally, we identified 25 secondary items and 53 tertiary items. Conclusion: This protocol demonstrates authenticity, objectivity, and broad applicability, providing a valuable reference for future psychological care and self-management strategies for colorectal cancer patients following surgery.

Fine particulate matter (PM2.5) exposure has been associated with increased incidence and mortality of lung cancer. However, the molecular mechanisms underlying PM2.5 carcinogenicity remain incompletely understood. Here, we identified that PM2.5 suppressed the expression of tRNA methyltransferase FTSJ1 and Am modification level of tRNA in vitro and in vivo. FTSJ1 downregulation enhanced glycolytic metabolism of non-small cell lung cancer (NSCLC) cells, as indicated by increased levels of lactate, pyruvate, and extracellular acidification rate (ECAR). Whereas treatment with glycolytic inhibitor 2-DG reversed this effect. In contrast, upregulation of FTSJ1 significantly suppressed glycolysis of NSCLC cells. Mechanistically, the silencing of FTSJ1 increased NSCLC cell proliferation and glycolysis through enhancing the expression and translation of PGK1. In human NSCLC tumor samples, FTSJ1 expression was negatively correlated with PGK1 expression level and the SUVmax value of PET/CT scan. In summary, our work reveals a previously unrecognized function of PM2.5-downregulated FTSJ1 on PGK1-mediated glycolysis in NSCLC, suggesting that targeted upregulation of FTSJ1 may represent a potential therapeutic strategy for NSCLC.

Background: Gynecological malignant patients often have significant psychological and physical problems. The feasibility and generalizability of traditional intervention method is low due to the high time and labor cost, large number of gynecological malignant tumor patients in China, as well as shortage of health professionals. Therefore, it is necessary to design an alternative, innovative, and easily accessible intervention method. This study aims to evaluate the effect of WeChat-based intervention on anxiety, depression and disease-related symptoms of patients with gynecological malignant tumors during rehabilitation. Methods: A single-blinded, randomized, controlled, parallel-group pre-test and repeated post-test design will be conducted. A total of 76 participants will be randomly divided into the intervention group and control group. Anxiety and depression, disease-related symptoms, coping ability, benefit finding and quality of life will be measured at baseline and repeated immediately after the intervention (test 1), 3 months (test 2) and 6 months (test 3) after the intervention. Discussion: As the first randomized controlled trial with rigorous research design for patients with gynecological malignant tumors in the rehabilitation stage in China, this study will provide evidences for the effectiveness of the WeChat platform during intervention of patients with gynecological malignant tumors in the rehabilitation stage. The results are helpful to further explore the effect of WeChat-based intervention on improving patients' anxiety and depression, disease-related symptoms, and quality of life. Trial registration: Chinese Clinical Trial Registry: ChiCTR2100053450, Registered 21 November 2021,http://www.chictr.org.cn/searchproj.aspx