Gianluca Boo
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Gianluca Boo has a total of 149 co-authors. Here are the top co-authors by number of shared publications:
- Sara Irina Fabrikant
University of Zürich
8 shared publications Andreas Pospischil
Collegium Helveticum, University of Zurich, ETH Zurich, Zurich, Switzerland
4 shared publications- Andreas Pospischil
University of Zurich, Zurich, Switzerland
4 shared publications - Andrew J. Tatem
WorldPop, University of Southampton
4 shared publications - Edith Darin
University of Oxford
4 shared publications Ramona Graf
Collegium Helveticum, University of Zurich, ETH Zurich, Zurich, Switzerland
4 shared publications
Latest Publications
- Open Access
- 21 August 2026
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 123 (35)
Advances in small area population estimation in the absence of national census data
Population data at small area scales are essential for effective decision-making, influencing public health, disaster response, and resource allocation, among others. While national censuses remain the cornerstone of population data, they are often constrained by high costs, infrequent collection cycles, and coverage gaps, which can hinder timely data availability. To address these challenges, geospatial statistical approaches using limited microcensus surveys have been demonstrated as a reliable source, but the field has advanced substantially in recent years, with significant developments in both data sources and modeling methodologies. New approaches now leverage routine health intervention campaign data, satellite-derived settlement maps, and bespoke modeling approaches to produce reliable small area population estimates where enumeration is difficult or outdated. Various countries are applying these techniques to support census operations, health program planning, and humanitarian response. This manuscript reviews recent advances in “bottom-up” population mapping approaches, highlighting innovations in input data, modeling methods, and validation techniques. We examine ongoing challenges, including partial observation of buildings under forest canopy, population displacement, and institutional uptake. Finally, we discuss emerging opportunities to enhance these approaches through better integration with traditional data ecosystems, capacity strengthening, and coproduction with national institutions.
- 21 August 2026
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 123 (35)
Open AccessAdvances in small area population estimation in the absence of national census data
Population data at small area scales are essential for effective decision-making, influencing public health, disaster response, and resource allocation, among others. While national censuses remain the cornerstone of population data, they are often constrained by high costs, infrequent collection cycles, and coverage gaps, which can hinder timely data availability. To address these challenges, geospatial statistical approaches using limited microcensus surveys have been demonstrated as a reliable source, but the field has advanced substantially in recent years, with significant developments in both data sources and modeling methodologies. New approaches now leverage routine health intervention campaign data, satellite-derived settlement maps, and bespoke modeling approaches to produce reliable small area population estimates where enumeration is difficult or outdated. Various countries are applying these techniques to support census operations, health program planning, and humanitarian response. This manuscript reviews recent advances in “bottom-up” population mapping approaches, highlighting innovations in input data, modeling methods, and validation techniques. We examine ongoing challenges, including partial observation of buildings under forest canopy, population displacement, and institutional uptake. Finally, we discuss emerging opportunities to enhance these approaches through better integration with traditional data ecosystems, capacity strengthening, and coproduction with national institutions.
- Open Access
- 13 July 2026
- Published by MDPI AG in Preprints.org
Advances in Small Area Population Estimation in the Absence of National Census Data
Population data at small area scales are essential for effective decision-making, influencing public health, disaster response, and resource allocation, amongst others. While national censuses remain the cornerstone of population data, they are often constrained by high costs, infrequent collection cycles, and coverage gaps, which can hinder timely data availability. To address these challenges, geospatial statistical approaches using limited microcensus surveys have been demonstrated as a reliable source, but the field has advanced substantially in recent years, with significant developments in both data sources and modelling methodologies. New approaches now leverage routine health intervention campaign data, satellite-derived settlement maps, and bespoke modelling approaches to produce reliable small area population estimates where enumeration is difficult or outdated. Various countries are applying these techniques to support census operations, health program planning, and humanitarian response. This manuscript reviews recent advances in ‘bottom-up’ population mapping approaches, highlighting innovations in input data, modelling methods, and validation techniques. We examine ongoing challenges, including partial observation of buildings under forest canopy, population displacement, and institutional uptake. Finally, we discuss emerging opportunities to enhance these approaches through better integration with traditional data ecosystems, capacity strengthening, and co-production with national institutions.
- 13 July 2026
- Published by MDPI AG in Preprints.org
Open AccessAdvances in Small Area Population Estimation in the Absence of National Census Data
Population data at small area scales are essential for effective decision-making, influencing public health, disaster response, and resource allocation, amongst others. While national censuses remain the cornerstone of population data, they are often constrained by high costs, infrequent collection cycles, and coverage gaps, which can hinder timely data availability. To address these challenges, geospatial statistical approaches using limited microcensus surveys have been demonstrated as a reliable source, but the field has advanced substantially in recent years, with significant developments in both data sources and modelling methodologies. New approaches now leverage routine health intervention campaign data, satellite-derived settlement maps, and bespoke modelling approaches to produce reliable small area population estimates where enumeration is difficult or outdated. Various countries are applying these techniques to support census operations, health program planning, and humanitarian response. This manuscript reviews recent advances in ‘bottom-up’ population mapping approaches, highlighting innovations in input data, modelling methods, and validation techniques. We examine ongoing challenges, including partial observation of buildings under forest canopy, population displacement, and institutional uptake. Finally, we discuss emerging opportunities to enhance these approaches through better integration with traditional data ecosystems, capacity strengthening, and co-production with national institutions.
- Open Access
- 4 September 2025
- Published by Public Library of Science (PLoS) in PLOS Global Public Health
- Vol. 5 (9) , e0005072
Tackling public health data gaps through Bayesian high-resolution population estimation: A case study of Kasaï-Oriental, Democratic Republic of the Congo
Most low- and middle-income countries face significant public health challenges, exacerbated by the lack of reliable demographic data supporting effective planning and intervention. In such data-scarce settings, statistical models combining geolocated survey data with geospatial datasets enable the estimation of population counts at high spatial resolution in the absence of dependable demographic data sources. This study introduces a Bayesian model jointly estimating building and population counts, combining geolocated survey data and gridded geospatial datasets. The model provides population estimates for the Kasaï-Oriental province, Democratic Republic of the Congo (DRC), at a spatial resolution of approximately one hectare. Posterior estimates are aggregated across health zones and health areas to offer probabilistic insights into their respective populations. The model exhibits a –0.28 bias, 0.47 inaccuracy, and 0.95 imprecision using scaled residuals, with robust 95% credible intervals. The estimated population of Kasaï-Oriental for 2024 is approximately 4.1 million, with a credible range of 3.4 to 4.8 million. Aggregations by health zones and health areas reveal significant variations in population estimates and uncertainty levels, particularly between the provincial capital, Mbuji-Mayi and the rural hinterland. High-resolution Bayesian population estimates allow flexible aggregation across spatial units while providing probabilistic insights into model uncertainty. These estimates offer a unique resource for the public health community working in Kasaï-Oriental, for instance, in support of a better-informed allocation of vaccines to different operational boundaries based on the upper bound of the 95% credible intervals.
- 4 September 2025
- Published by Public Library of Science (PLoS) in PLOS Global Public Health
- Vol. 5 (9) , e0005072
Open AccessTackling public health data gaps through Bayesian high-resolution population estimation: A case study of Kasaï-Oriental, Democratic Republic of the Congo
Most low- and middle-income countries face significant public health challenges, exacerbated by the lack of reliable demographic data supporting effective planning and intervention. In such data-scarce settings, statistical models combining geolocated survey data with geospatial datasets enable the estimation of population counts at high spatial resolution in the absence of dependable demographic data sources. This study introduces a Bayesian model jointly estimating building and population counts, combining geolocated survey data and gridded geospatial datasets. The model provides population estimates for the Kasaï-Oriental province, Democratic Republic of the Congo (DRC), at a spatial resolution of approximately one hectare. Posterior estimates are aggregated across health zones and health areas to offer probabilistic insights into their respective populations. The model exhibits a –0.28 bias, 0.47 inaccuracy, and 0.95 imprecision using scaled residuals, with robust 95% credible intervals. The estimated population of Kasaï-Oriental for 2024 is approximately 4.1 million, with a credible range of 3.4 to 4.8 million. Aggregations by health zones and health areas reveal significant variations in population estimates and uncertainty levels, particularly between the provincial capital, Mbuji-Mayi and the rural hinterland. High-resolution Bayesian population estimates allow flexible aggregation across spatial units while providing probabilistic insights into model uncertainty. These estimates offer a unique resource for the public health community working in Kasaï-Oriental, for instance, in support of a better-informed allocation of vaccines to different operational boundaries based on the upper bound of the 95% credible intervals.
- Open Access
- 16 September 2022
- Published by Springer Nature in Communications Medicine
- Vol. 2 (1) , 1-13
Differences between gridded population data impact measures of geographic access to healthcare in sub-Saharan Africa
Background: Access to healthcare is imperative to health equity and well-being. Geographic access to healthcare can be modeled using spatial datasets on local context, together with the distribution of existing health facilities and populations. Several population datasets are currently available, but their impact on accessibility analyses is unknown. In this study, we model the geographic accessibility of public health facilities at 100-meter resolution in sub-Saharan Africa and evaluate six of the most popular gridded population datasets for their impact on coverage statistics at different administrative levels. Methods: Travel time to nearest health facilities was calculated by overlaying health facility coordinates on top of a friction raster accounting for roads, landcover, and physical barriers. We then intersected six different gridded population datasets with our travel time estimates to determine accessibility coverages within various travel time thresholds (i.e., 30, 60, 90, 120, 150, and 180-min). Results: Here we show that differences in accessibility coverage can exceed 70% at the sub-national level, based on a one-hour travel time threshold. The differences are most notable in large and sparsely populated administrative units and dramatically shape patterns of healthcare accessibility at national and sub-national levels. Conclusions: The results of this study show how valuable and critical a comparative analysis between population datasets is for the derivation of coverage statistics that inform local policies and monitor global targets. Large differences exist between the datasets and the results underscore an essential source of uncertainty in accessibility analyses that should be systematically assessed.
- 16 September 2022
- Published by Springer Nature in Communications Medicine
- Vol. 2 (1) , 1-13
Open AccessDifferences between gridded population data impact measures of geographic access to healthcare in sub-Saharan Africa
Background: Access to healthcare is imperative to health equity and well-being. Geographic access to healthcare can be modeled using spatial datasets on local context, together with the distribution of existing health facilities and populations. Several population datasets are currently available, but their impact on accessibility analyses is unknown. In this study, we model the geographic accessibility of public health facilities at 100-meter resolution in sub-Saharan Africa and evaluate six of the most popular gridded population datasets for their impact on coverage statistics at different administrative levels. Methods: Travel time to nearest health facilities was calculated by overlaying health facility coordinates on top of a friction raster accounting for roads, landcover, and physical barriers. We then intersected six different gridded population datasets with our travel time estimates to determine accessibility coverages within various travel time thresholds (i.e., 30, 60, 90, 120, 150, and 180-min). Results: Here we show that differences in accessibility coverage can exceed 70% at the sub-national level, based on a one-hour travel time threshold. The differences are most notable in large and sparsely populated administrative units and dramatically shape patterns of healthcare accessibility at national and sub-national levels. Conclusions: The results of this study show how valuable and critical a comparative analysis between population datasets is for the derivation of coverage statistics that inform local policies and monitor global targets. Large differences exist between the datasets and the results underscore an essential source of uncertainty in accessibility analyses that should be systematically assessed.
- Top Cited PapersOpen Access
- 14 March 2022
- Published by Springer Nature in Nature Communications
- Vol. 13 (1) , 1-10
High-resolution population estimation using household survey data and building footprints
The national census is an essential data source to support decision-making in many areas of public interest. However, this data may become outdated during the intercensal period, which can stretch up to several decades. In this study, we develop a Bayesian hierarchical model leveraging recent household surveys and building footprints to produce up-to-date population estimates. We estimate population totals and age and sex breakdowns with associated uncertainty measures within grid cells of approximately 100 m in five provinces of the Democratic Republic of the Congo, a country where the last census was completed in 1984. The model exhibits a very good fit, with anR2value of 0.79 for out-of-sample predictions of population totals at the microcensus-cluster level and 1.00 for age and sex proportions at the province level. This work confirms the benefits of combining household surveys and building footprints for high-resolution population estimation in countries with outdated censuses.
- 14 March 2022
- Published by Springer Nature in Nature Communications
- Vol. 13 (1) , 1-10
Top Cited PapersOpen AccessHigh-resolution population estimation using household survey data and building footprints
The national census is an essential data source to support decision-making in many areas of public interest. However, this data may become outdated during the intercensal period, which can stretch up to several decades. In this study, we develop a Bayesian hierarchical model leveraging recent household surveys and building footprints to produce up-to-date population estimates. We estimate population totals and age and sex breakdowns with associated uncertainty measures within grid cells of approximately 100 m in five provinces of the Democratic Republic of the Congo, a country where the last census was completed in 1984. The model exhibits a very good fit, with anR2value of 0.79 for out-of-sample predictions of population totals at the microcensus-cluster level and 1.00 for age and sex proportions at the province level. This work confirms the benefits of combining household surveys and building footprints for high-resolution population estimation in countries with outdated censuses.
- Open Access
- 23 June 2021
- Published by Public Library of Science (PLoS) in PLOS Neglected Tropical Diseases
- Vol. 15 (6) , e0009498
Association between environmental and climatic risk factors and the spatial distribution of cystic and alveolar echinococcosis in Kyrgyzstan
Background: Cystic and alveolar echinococcosis (CE and AE) are neglected tropical diseases caused byEchinococcus granulosus sensu latoandE.multilocularis, and are emerging zoonoses in Kyrgyzstan. In this country, the spatial distribution of CE and AE surgical incidence in 2014-2016 showed marked heterogeneity across communities, suggesting the presence of ecological determinants underlying CE and AE distributions.Methodology/Principal findings: For this reason, in this study we assessed potential associations between community-level confirmed primary CE (no.=2359) or AE (no.=546) cases in 2014-2016 in Kyrgyzstan and environmental and climatic variables derived from satellite-remote sensing datasets using conditional autoregressive models. We also mapped CE and AE relative risk. The number of AE cases was negatively associated with 10-year lag mean annual temperature. Although this time lag should not be considered as an exact measurement but with associated uncertainty, it is consistent with the estimated 10–15-year latency following AE infection. No associations were detected for CE. We also identified several communities at risk for CE or AE where no disease cases were reported in the study period.Conclusions/Significance: Our findings support the hypothesis that CE is linked to an anthropogenic cycle and is less affected by environmental risk factors compared to AE, which is believed to result from spillover from a wild life cycle. As CE was not affected by factors we investigated, hence control should not have a geographical focus. In contrast, AE risk areas identified in this study without reported AE cases should be targeted for active disease surveillance in humans. This active surveillance would confirm or exclude AE transmission which might not be reported with the present passive surveillance system. These areas should also be targeted for ecological investigations in the animal hosts.
- 23 June 2021
- Published by Public Library of Science (PLoS) in PLOS Neglected Tropical Diseases
- Vol. 15 (6) , e0009498
Open AccessAssociation between environmental and climatic risk factors and the spatial distribution of cystic and alveolar echinococcosis in Kyrgyzstan
Background: Cystic and alveolar echinococcosis (CE and AE) are neglected tropical diseases caused byEchinococcus granulosus sensu latoandE.multilocularis, and are emerging zoonoses in Kyrgyzstan. In this country, the spatial distribution of CE and AE surgical incidence in 2014-2016 showed marked heterogeneity across communities, suggesting the presence of ecological determinants underlying CE and AE distributions.Methodology/Principal findings: For this reason, in this study we assessed potential associations between community-level confirmed primary CE (no.=2359) or AE (no.=546) cases in 2014-2016 in Kyrgyzstan and environmental and climatic variables derived from satellite-remote sensing datasets using conditional autoregressive models. We also mapped CE and AE relative risk. The number of AE cases was negatively associated with 10-year lag mean annual temperature. Although this time lag should not be considered as an exact measurement but with associated uncertainty, it is consistent with the estimated 10–15-year latency following AE infection. No associations were detected for CE. We also identified several communities at risk for CE or AE where no disease cases were reported in the study period.Conclusions/Significance: Our findings support the hypothesis that CE is linked to an anthropogenic cycle and is less affected by environmental risk factors compared to AE, which is believed to result from spillover from a wild life cycle. As CE was not affected by factors we investigated, hence control should not have a geographical focus. In contrast, AE risk areas identified in this study without reported AE cases should be targeted for active disease surveillance in humans. This active surveillance would confirm or exclude AE transmission which might not be reported with the present passive surveillance system. These areas should also be targeted for ecological investigations in the animal hosts.
- Open Access
- 13 May 2020
- Published by MDPI AG in Social Sciences
- Vol. 9 (5) , 80
Need for an Integrated Deprived Area “Slum” Mapping System (IDEAMAPS) in Low- and Middle-Income Countries (LMICs)
Ninety percent of the people added to the planet over the next 30 years will live in African and Asian cities, and a large portion of these populations will reside in deprived neighborhoods defined by slum conditions, informal settlement, or inadequate housing. The four current approaches to neighborhood deprivation mapping are largely siloed, and each fall short of producing accurate, timely, and comparable maps that reflect local contexts. The first approach, classifying “slum households” in census and survey data, reflects household-level rather than neighborhood-level deprivation. The second approach, field-based mapping, can produce the most accurate and context-relevant maps for a given neighborhood, however it requires substantial resources, preventing up-scaling. The third and fourth approaches, human (visual) interpretation and machine classification of air or spaceborne imagery, both overemphasize informal settlements, and fail to represent key social characteristics of deprived areas such as lack of tenure, exposure to pollution, and lack of public services. We summarize common areas of understanding, and present a set of requirements and a framework to produce routine, accurate maps of deprived urban areas that can be used by local-to-international stakeholders for advocacy, planning, and decision-making across Low- and Middle-Income Countries (LMICs). We suggest that machine learning models be extended to incorporate social area-level covariates and regular contributions of up-to-date and context-relevant field-based classification of deprived urban areas.
- 13 May 2020
- Published by MDPI AG in Social Sciences
- Vol. 9 (5) , 80
Open AccessNeed for an Integrated Deprived Area “Slum” Mapping System (IDEAMAPS) in Low- and Middle-Income Countries (LMICs)
Ninety percent of the people added to the planet over the next 30 years will live in African and Asian cities, and a large portion of these populations will reside in deprived neighborhoods defined by slum conditions, informal settlement, or inadequate housing. The four current approaches to neighborhood deprivation mapping are largely siloed, and each fall short of producing accurate, timely, and comparable maps that reflect local contexts. The first approach, classifying “slum households” in census and survey data, reflects household-level rather than neighborhood-level deprivation. The second approach, field-based mapping, can produce the most accurate and context-relevant maps for a given neighborhood, however it requires substantial resources, preventing up-scaling. The third and fourth approaches, human (visual) interpretation and machine classification of air or spaceborne imagery, both overemphasize informal settlements, and fail to represent key social characteristics of deprived areas such as lack of tenure, exposure to pollution, and lack of public services. We summarize common areas of understanding, and present a set of requirements and a framework to produce routine, accurate maps of deprived urban areas that can be used by local-to-international stakeholders for advocacy, planning, and decision-making across Low- and Middle-Income Countries (LMICs). We suggest that machine learning models be extended to incorporate social area-level covariates and regular contributions of up-to-date and context-relevant field-based classification of deprived urban areas.
- Open Access
- 1 April 2020
- Published by Elsevier in The Lancet Global Health
- Vol. 8 (4) , e603-e611
Epidemic cystic and alveolar echinococcosis in Kyrgyzstan: an analysis of national surveillance data
- 1 April 2020
- Published by Elsevier in The Lancet Global Health
- Vol. 8 (4) , e603-e611
Open AccessEpidemic cystic and alveolar echinococcosis in Kyrgyzstan: an analysis of national surveillance data
- Open Access
- 18 March 2020
- Published by MDPI AG in Remote Sensing
- Vol. 12 (6) , 982
The Role of Earth Observation in an Integrated Deprived Area Mapping “System” for Low-to-Middle Income Countries
Urbanization in the global South has been accompanied by the proliferation of vast informal and marginalized urban areas that lack access to essential services and infrastructure. UN-Habitat estimates that close to a billion people currently live in these deprived and informal urban settlements, generally grouped under the term of urban slums. Two major knowledge gaps undermine the efforts to monitor progress towards the corresponding sustainable development goal (i.e., SDG 11—Sustainable Cities and Communities). First, the data available for cities worldwide is patchy and insufficient to differentiate between the diversity of urban areas with respect to their access to essential services and their specific infrastructure needs. Second, existing approaches used to map deprived areas (i.e., aggregated household data, Earth observation (EO), and community-driven data collection) are mostly siloed, and, individually, they often lack transferability and scalability and fail to include the opinions of different interest groups. In particular, EO-based-deprived area mapping approaches are mostly top-down, with very little attention given to ground information and interaction with urban communities and stakeholders. Existing top-down methods should be complemented with bottom-up approaches to produce routinely updated, accurate, and timely deprived area maps. In this review, we first assess the strengths and limitations of existing deprived area mapping methods. We then propose an Integrated Deprived Area Mapping System (IDeAMapS) framework that leverages the strengths of EO- and community-based approaches. The proposed framework offers a way forward to map deprived areas globally, routinely, and with maximum accuracy to support SDG 11 monitoring and the needs of different interest groups.
- 18 March 2020
- Published by MDPI AG in Remote Sensing
- Vol. 12 (6) , 982
Open AccessThe Role of Earth Observation in an Integrated Deprived Area Mapping “System” for Low-to-Middle Income Countries
Urbanization in the global South has been accompanied by the proliferation of vast informal and marginalized urban areas that lack access to essential services and infrastructure. UN-Habitat estimates that close to a billion people currently live in these deprived and informal urban settlements, generally grouped under the term of urban slums. Two major knowledge gaps undermine the efforts to monitor progress towards the corresponding sustainable development goal (i.e., SDG 11—Sustainable Cities and Communities). First, the data available for cities worldwide is patchy and insufficient to differentiate between the diversity of urban areas with respect to their access to essential services and their specific infrastructure needs. Second, existing approaches used to map deprived areas (i.e., aggregated household data, Earth observation (EO), and community-driven data collection) are mostly siloed, and, individually, they often lack transferability and scalability and fail to include the opinions of different interest groups. In particular, EO-based-deprived area mapping approaches are mostly top-down, with very little attention given to ground information and interaction with urban communities and stakeholders. Existing top-down methods should be complemented with bottom-up approaches to produce routinely updated, accurate, and timely deprived area maps. In this review, we first assess the strengths and limitations of existing deprived area mapping methods. We then propose an Integrated Deprived Area Mapping System (IDeAMapS) framework that leverages the strengths of EO- and community-based approaches. The proposed framework offers a way forward to map deprived areas globally, routinely, and with maximum accuracy to support SDG 11 monitoring and the needs of different interest groups.
- Open Access
- 27 January 2020
- Published by F1000 Research Ltd in Gates Open Research
- Vol. 4, 13
A grid-based sample design framework for household surveys
Traditional sample designs for household surveys are contingent upon the availability of a representative primary sampling frame. This is defined using enumeration units and population counts retrieved from decennial national censuses that can become rapidly inaccurate in highly dynamic demographic settings. To tackle the need for representative sampling frames, we propose an original grid-based sample design framework introducing essential concepts of spatial sampling in household surveys. In this framework, the sampling frame is defined based on gridded population estimates and formalized as a bi-dimensional random field, characterized by spatial trends, spatial autocorrelation, and stratification. The sampling design reflects the characteristics of the random field by combining contextual stratification and proportional to population size sampling. A nonparametric estimator is applied to evaluate the sampling design and inform sample size estimation. We demonstrate an application of the proposed framework through a case study developed in two provinces located in the western part of the Democratic Republic of the Congo. We define a sampling frame consisting of settled cells with associated population estimates. We then perform a contextual stratification by applying a principal component analysis (PCA) and k-means clustering to a set of gridded geospatial covariates, and sample settled cells proportionally to population size. Lastly, we evaluate the sampling design by contrasting the empirical cumulative distribution function for the entire population of interest and its weighted counterpart across different sample sizes and identify an adequate sample size using the Kolmogorov-Smirnov distance between the two functions. The results of the case study underscore the strengths and limitations of the proposed grid-based sample design framework and foster further research into the application of spatial sampling concepts in household surveys.
- 27 January 2020
- Published by F1000 Research Ltd in Gates Open Research
- Vol. 4, 13
Open AccessA grid-based sample design framework for household surveys
Traditional sample designs for household surveys are contingent upon the availability of a representative primary sampling frame. This is defined using enumeration units and population counts retrieved from decennial national censuses that can become rapidly inaccurate in highly dynamic demographic settings. To tackle the need for representative sampling frames, we propose an original grid-based sample design framework introducing essential concepts of spatial sampling in household surveys. In this framework, the sampling frame is defined based on gridded population estimates and formalized as a bi-dimensional random field, characterized by spatial trends, spatial autocorrelation, and stratification. The sampling design reflects the characteristics of the random field by combining contextual stratification and proportional to population size sampling. A nonparametric estimator is applied to evaluate the sampling design and inform sample size estimation. We demonstrate an application of the proposed framework through a case study developed in two provinces located in the western part of the Democratic Republic of the Congo. We define a sampling frame consisting of settled cells with associated population estimates. We then perform a contextual stratification by applying a principal component analysis (PCA) and k-means clustering to a set of gridded geospatial covariates, and sample settled cells proportionally to population size. Lastly, we evaluate the sampling design by contrasting the empirical cumulative distribution function for the entire population of interest and its weighted counterpart across different sample sizes and identify an adequate sample size using the Kolmogorov-Smirnov distance between the two functions. The results of the case study underscore the strengths and limitations of the proposed grid-based sample design framework and foster further research into the application of spatial sampling concepts in household surveys.