Anna Maria Della Vedova

The postnatal period involves significant emotional and relational shifts that can challenge early mother–infant interactions, particularly under conditions of psychosocial vulnerability (e.g., maternal anxiety/depression) or infant-related risk (e.g., preterm birth). Maternal mentalization, operationalized as Parental Reflective Functioning (PRF), is a key protective factor for sensitive caregiving and dyadic regulation. Objectives: This protocol describes a multicenter, open-label, single-arm feasibility study evaluating a brief, fully online, mentalization-based video-feedback intervention (VFI-RF). The study is designed to assess the feasibility and acceptability of the intervention, rather than its efficacy. We aim to recruit 48 mothers, 24 in each of two risk groups, through socio-health services and neonatal intensive care units. Risk Group 1 will include mothers with clinically significant depressive and/or anxiety symptoms, defined as EPDS > 9 and/or GAD-7 ≥ 10, whereas Risk Group 2 will include mothers of preterm infants, defined as infants born before 37 weeks of gestation. Methods: The intervention consists of 8 + 2 synchronous online sessions over approximately 5 months. Mothers record brief everyday caregiving interactions (~5 min) to review with a trained clinician, focusing on the infant’s internal states and reflective meaning-making. Assessments occur at baseline (T0, infant age ~3 months), post-intervention (T1, ~8 months), and follow-up (T2, ~12 months). Primary feasibility outcomes include recruitment/referral metrics, uptake, retention, assessment completion, missing data, and participant-reported acceptability. Secondary exploratory clinical outcomes include maternal PRF, symptoms, parenting stress, social support, and mother–infant attachment, evaluated via validated self-report questionnaires. Results: The study is designed to evaluate referral and recruitment patterns, intervention uptake, and participant retention, as well as the acceptability and suitability of study procedures and outcome measures for a future controlled trial. Preliminary trajectories of change in maternal reflective functioning and early relational indicators will be examined descriptively and exploratorily. Conclusions: Findings will inform the feasibility and refinement of a brief online mentalization-based video-feedback intervention to support at-risk mother–infant dyads during the first postnatal year. Trial registration: Registered on Open Science Framework, osf.io/6g9ja, date of registration 4th March 2026.

Background: Unplanned pregnancy is a public health issue and understanding women’s decision making aids practitioners in assessing fertility trends, contraception use, and family planning counselling. In Italy, Catholicism reinforces ‘natural reproduction’ and ‘traditional’ contraception, making it an ‘Imperfect Contraceptive Society.’ A valid and reliable measure of pregnancy intentionality is increasingly important, and the London Measure of Unplanned Pregnancy (LMUP) has proved effective. Objectives and Methods: This study comprised four stages: (1) English–Italian translation and back-translation to create the Italian version [LMUP-IT]; (2) online data collection from postnatal women; (3) evaluation of its psychometric properties (targeting, reliability, construct validity via CFA and measurement invariance with a UK sample, ‘known groups’ hypothesis testing); and (4) exploratory analysis of its associations with perinatal mental health. The sample comprised 450 postnatal women (M_age = 33.6 ± 4.5). Results: The LMUP-IT was shown to be reliable (ωT = 0.81, α = 0.76), with acceptable targeting. Measurement invariance testing confirmed consistency with the UK sample in factor structure, loadings, intercepts, and errors. LMUP-IT scores significantly correlated with well-known indicators of perinatal mental health. Conclusions: Overall, the LMUP-IT is a reliable measure of pregnancy intention in Italian for postpartum women. Understanding pregnancy intention will help healthcare professionals tailor interventions to better support women’s mental health during the transition to motherhood.

Pregnancy is a period of great complexity and potential psychological vulnerability which may increase in unfavorable conditions, such as hospitalization. Therefore, early identification of emotional, anxious, or depressive difficulties is important in terms of maternal and fetal well-being. International guidelines recommend the use of brief screening tools to identify perinatal women for further investigation, but which of the measures is optimal remains to be clarified. The objective of this study was to compare the Whooley depression questions used together with the Generalized Anxiety Disorder-2 (GAD-2), versus the Matthey Generic Mood Questionnaire (MGMQ), to evaluate their concordance in screening results and their clinical usefulness in the hospital setting. Hospitalized pregnant women, numbering 228, and 55 male partners completed both questionnaires. The women’s results showed high similar screen positive rates on both measures, but the screen positive concordance between the two instruments was low (around 50%). The Whooley/GAD-2 missed a significant percentage of women who, on the MGMQ, wished to talk with a professional, or who expressed moderate to high distress. The data from male partners were too few to be interpretable. Findings suggest that screening is important in hospitalized women, and clinicians should consider the respective merits and possible weaknesses of different screening tools.

Pregnancy is a period of great complexity and potential psychological vulnerability which may increase in unfavorable conditions, such as hospitalization. Therefore, ear-ly identification of emotional, anxious or depressive difficulties is important in terms of maternal and fetal well-being. International guidelines recommend the use of brief screening tools to identify perinatal women for further investigation, but which meas-ure is optimal remains to be clarified. The objective of this study was to compare the Whooley depression questions used together with the Generalized Anxiety Disorder-2 (GAD-2), versus the Matthey Generic Mood Questionnaire (MGMQ), to evaluate their concordance in screening results and their clinical usefulness in the hospital setting. 228, hospitalized pregnant women, and some of their partners, completed both ques-tionnaires, and expressed their satisfaction and ease of completion of each. Results showed high similar screen positive rates on both measures, but the screen positive concordance between the two instruments was low (around 50%). The Whooley/GAD-2 missed a significant percentage of women who, on the MGMQ, wished to talk with a professional, or who expressed moderate to high distress. Find-ings suggest that screening is important in hospitalized women, and clinicians should consider the respective merits and possible weaknesses of different screening tools.

Extensive research indicates that cognitive interventions can lead to a general improvement in cognitive functioning throughout the lifespan. In this study, we evaluate the causal evidence supporting this relationship in healthy older adults and older adults with mild cognitive impairment (MCI) by means of an umbrella meta‐analysis of meta‐analyses. The meta‐analytic studies were identified through systematic searches in electronic databases (CINAHL, Cochrane Library, PsycINFO, PubMed, Scopus, and Web of Science) and were included in this umbrella meta‐analysis if they examined the effects of cognitive interventions, not mixed with other approaches, in healthy older adults and individuals with MCI. Of the 9734 publications that were screened, 25 met the inclusion criteria and reported comprehensive data suitable for statistical analysis. Findings showed that although the effect‐sizes across studies were variable, they were consistently positive, indicating a significant impact of different cognitive interventions on global cognitive functioning, memory, executive functions, visuospatial ability, and processing speed compared to control groups. This finding suggests that the efficacy of cognitive treatments is the best option for preclinical forms of aging, such as MCI. The underlying mechanisms of the observed improvements and their implications for further studies and clinical practice are discussed.

Adolescence is a central phase for the development of a person’s identity, involving complex multidimensional changes and increasing vulnerability to distress. This study aimed to investigate the psychological well-being of adolescent students in Brescia (Northern Italy), two years after the beginning of the COVID-19 pandemic. An online survey investigated the extent and the reasons reported by high school students (13–21 years) for their emotional distress (ED), also considering other factors such as physical activity, nutrition, sleep and smartphone overuse. The main reasons for ED were classified through a qualitative analysis of the free-text answers. A total of 1686 students agreed to participate, and 50% showed a presence of ED. According to a multiple logistic analysis, adolescents were more at risk of ED if they were female (AdjOR 2.3), older (AdjOR 1.6), slept less than 8 h (AdjOR 1.5), perceived increased anxiety (AdjOR 3.4), and adopted certain eating behaviors, e.g., comfort food consumption (AdjOR 2.0). According to free-text answers, the main reasons for ED were “school pressure”, “relationships with family and peers”, “negative emotional states” and “the pandemic”. The results show a high level of ED among adolescents, and the reported reasons may help to better address their psychological needs after the pandemic.

Adolescence is a central phase for the development of a person’s identity involving complex multidimensional changes and increasing vulnerability to distress. The aim of this study was to investigate the psychological well-being of adolescent students in Brescia (Northern Italy), two years after the beginning of the Covid-19 pandemic. An online survey investigated the extent and the reasons reported by high school students for their emotional distress (ED), also considering other factors such as physical activity, diet, sleep and smartphone overuse. The main reasons for ED were classified through a qualitative analysis of the freetext answers. 1686 students agreed to participate, 50% showed a presence of ED. According to a multiple logistic analysis, the main factors associated to ED were female gender (AdjOR 2.3, p<0.0001), age (AdjOR 1.6, p<0.0001), sleep duration <8 hours (AdjOR 1.5, p=0.0003), anxiety perception (AdjOR 3.4, p<0.0001), and certain eating behaviors, e.g. comfort food consumption (AdjOR 2.0, p<0.0001). According to free-text answers, the main reasons for ED were: “school pressure”, “ relationships with family and peers”, “negative emotional states” and “the pandemic”. The results show a high level of ED among adolescents and the reported reasons may help to better address their psychological needs after the pandemic.

The role of anxiety is unknown in relation to postpartum bonding, unlike the well-known detrimental effect that postpartum depression has on the relationship between a mother and child. This study investigates how anxiety affects mother–infant bonding after childbirth, comparing the Italian version of the Postpartum Specific Anxiety Scale (PSAS-IT) with generalized measures of anxiety. Examining 324 non-randomly-selected participants responding to various scales, including the Edinburgh postnatal depression scale (EPDS), generalized anxiety disorder (GAD), postpartum-specific anxiety scale (PSAS-IT), postpartum bonding questionnaire (PBQ), and baby care questionnaire (BCQ-2), initial results suggest a link between certain postpartum anxiety symptoms and attachment problems. Surprisingly, anxiety measured with the PSAS has no direct influence on attachment; however, it is a strong predictor of bonding, even when maternal age, general anxiety, and depression are taken into account, explaining 3% of the variance in scores (β = 0.26, p < 0.001). This emphasizes the importance of early identification and intervention of postpartum anxiety in promoting bonding between mother and child.

The quality of the early parent–infant relationship is crucial for the child’s optimal development, and parental sensitivity plays a key role in early interactions. The purpose of the study was to evaluate the influence of maternal perinatal depression and anxiety symptoms on dyadic sensitivity at three months post-partum, also considering a large set of maternal and infant variables. At the third trimester of pregnancy (T1) and at three months postpartum (T2), 43 primiparous women filled in a set of questionnaires evaluating symptoms of depression (CES-D) or anxiety (STAI), the woman’s parental bonding experiences (PBI), alexithymia (TAS-20), maternal attachment to the baby (PAI, MPAS) and the perceived social support (MSPSS). At T2 mothers also completed a questionnaire on infant temperament and took part in the CARE-Index videotaped procedure. Dyadic sensitivity was predicted by higher maternal trait anxiety scores in pregnancy. In addition, the mother’s experience of being cared for by her father in childhood was predictive of her infant’s lower compulsivity, while paternal overprotection predicted higher unresponsiveness. The results highlight the influence of perinatal maternal psychological well-being and maternal childhood experiences on the quality of the dyadic relationship. The results may be useful to foster mother–child adjustment during the perinatal period.