Adinath Majee

An in silico approach for evaluating the antioxidant properties of known and potential compounds was studied using conventional DFT calculations.

Aziridine, a three-membered nitrogen-containing heterocyclic ring, is a versatile building block in organic synthesis. Due to high ring strain, it tends to undergo ring opening reactions under the influence of nucleophilic reagents. Facile construction of four- to seven-membered aza-heterocyclic ring systems is a challenging task for synthetic organic chemists. Fortunately, this small scaffold (aziridine) is an ideal starting material for conversion into larger nitrogenated heterocycles. This review presents some illustrative and contemporary examples to demonstrate the synthetic utility and efficiency of the ring-expansion strategies of the aziridines towards a wide range of small to medium-sized aza-heterocyclic moieties of pharmaceutical importance.

Aza‐Michael addition is regarded as one of the most popular and efficient methods for forming the carbon–nitrogen bond in organic synthesis. Aza‐Michael addition of aromatic amines to various electron‐deficient alkenes was performed using a deep eutectic solvent (DES) at 70°C temperature, affording the corresponding Michael addition products in good to excellent yields. The method features the use of non‐metal catalysis, easy operation, and uses an environmentally friendly eutectic solvent. In addition, this protocol is also applicable for gram‐scale synthesis. The product can be easily converted to the corresponding carboxylic acid.

Aziridine, a three-membered nitrogen-containing heterocyclic ring, is a versatile building block in organic synthesis. Due to the high ring strain it tends to undergo ring opening reactions under the influence of nucleophilic reagents. Facile construction of four to seven-membered aza-heterocyclic ring systems is a challenging task for the synthetic organic chemists. Fortunately, this small scaffold (aziridine) is an ideal starting material for conversion into larger nitrogenated heterocycles. This review presents some of the illustrative and contemporary examples to demonstrate the synthetic utility and efficiency of the ring-expansion strategies of the aziridines towards a wide range of small to medium-sized aza-heterocyclic moieties of pharmaceutical importance.

A sulfoximination reaction is introduced between α ‐amino‐arylketones and NH‐sulfoximines initiated by visible light. The cost‐effective and readily accessible hypervalent iodine reagent (PIDA) easily promotes the oxidative sulfoximination process to afford N‐ α ‐ketoacylated sulfoximines in good to high yields, involving the formation of new C─O bonds and one C─N bond. Additionally, the protocol offers noteworthy advantages, including its metal‐free and photocatalyst‐free process with its broad substrate compatibility.

A metal-free iodine/DMSO protocol enables oxidative difunctionalization of indoles via C(sp ² )–H coupling between amines and diphenyl dichalcogenides under mild conditions, affording C(sp ² )–N and C(sp ² )–S/Se bonds in good yields.

An efficient and greener one‐pot method have been developed for the synthesis of 2,4‐disubstituted imidazole derivative by using deep eutectic solvent (DES), via formation of benzamidine, nucleophilic addition and finally liberation of N2 by the formation of hydrogen bond without using any metal, base or additive. Here, DES plays a dual role as alternative solvent and catalyst by giving interesting yields and functional group tolerance in the reaction conditions.

Microwave (MW)‐assisted organic synthesis of various heterocyclic groups is an efficient and environmentally friendly synthetic route, which is becoming an effective tool for green chemistry methods. The synthesis of highly substituted imidazole derivatives has been accomplished from various substituted anilines, glyoxals, and ammonium thiocyanate using microwave irradiation within very short reaction times of 2 min. This method provided a very good technique in modern organic synthesis to prepare various substituted imidazoles in excellent yield under minimum reaction time.

We report a metal-free approach for the oxidative difunctionalization of indole moieties using a hypervalent iodine reagent.

Recyclable ionic liquid-catalyzed mechanochemical synthesis of pyrrolo[1,2- a ]indoles was reported with high EcoScale metrics and a low E-factor. Their antimicrobial and photophysical properties were also studied.