Yong-Jun Kim

In this study, we present an integrated microfluidic-based ultrafine water condensation particle counter (UWCPC) developed by innovatively combining lab-on-printed circuit board (PCB) and three-dimensional (3D)-printing technologies. The combined lab-on-PCB and 3D-printing technology used for UWCPC development is an optimized method for manufacturing low-cost miniaturized integrated microfluidic devices. Notably, high-precision, harmless nanoparticle measurements were realized using a sheath/sample air separator and a moderated water condensation method. This novel methodology provides a highly accurate, harmless, low-cost, miniaturized system for multipoint monitoring of airborne nanoparticle generation and growth mechanisms. Our system consisted of three main parts—a sample/sheath air separator, a nanoparticle growth sector, and a miniaturized optical particle counter (OPC)—and was rigorously evaluated using simulations to confirm its optimal design and performance. The nanoparticle growth sector consisted of PCBs and 3D-printed structures; the heater, various sensors, and super hydrophilic micro-pillar array wick necessary for nanoparticle growth were integrated on the PCBs. Through quantitative laboratory experiments, we determined that our system was capable of counting particles 3.4 nm in diameter. In addition, the role and effect of the sheath air were confirmed by measuring the particle counting efficiency according to the ratio of the sample and sheath air. Finally, high concordance was confirmed through one-to-one comparison with a reference aerosol instrument in a wide particle number concentration range (0–57 000 N cm⁻³). Accordingly, if sufficient field tests in the environment confirm the practical use of the developed UWCPC, the generation and growth mechanism of nanoparticles in the air can be monitored.

This paper presents the mechanical behaviors of different types of polyimide feedthroughs that are frequently used for implantable polymer encapsulation. Implantable packages of electronic devices often comprise circuits mounted on printed circuit boards (PCBs) encapsulated in a biocompatible polymer material, with input/output feedthroughs for electrical interconnections. The feedthroughs are regarded as essential elements of the reliability of the package since they create inevitable interfaces with the encapsulation materials. Flexible materials are frequently used for feedthroughs owing to their ease of manufacturing; thus, their mechanical properties are crucial as they directly interact with parts of the human body, such as the brain and neurons. For this purpose, tensile tests were performed to characterize the mechanical properties of flexible PCBs (FPCBs) and photosensitive polyimides (PSPIs). Commercial FPCBs and homemade PSPIs of two different thicknesses were subjected to tensile tests for mechanical characterization. The FPCBs showed typical stress–strain curves, while the PSPIs showed brittleness or strain hardening depending on the thickness. The material properties extracted from the tensile tests were used for explicit modeling using the finite element method (FEM) and simulations to assess mechanical behaviors, such as necking and strain hardening.

This paper proposed and verified the use of polymer-based packaging to implement the chronic implantation of neural interfaces using a combination of a commercial thermal epoxy and a thin parylene film. The packaging’s characteristics and the performance of the vulnerable interface between the thermal epoxy layer and polyimide layer, which is mainly used for neural electrodes and an FPCB, were evaluated through in vitro, in vivo, and acceleration experiments. The performance of neural interfaces—composed of the combination of the thermal epoxy and thin parylene film deposition as encapsulation packaging—was evaluated by using signal acquisition experiments based on artificial stimulation signal transmissions through in vitro and in vivo experiments. It has been found that, when commercial thermal epoxy normally cured at room temperature was cured at higher temperatures of 45 °C and 65 °C, not only is its lifetime increased with about twice the room-temperature-based curing conditions but also an interfacial adhesion is higher with more than twice the room-temperature-based curing conditions. In addition, through in vivo experiments using rats, it was confirmed that bodily fluids did not flow into the interface between the thermal epoxy and FPCB for up to 18 months, and it was verified that the rats maintained healthy conditions without occurring an immune response in the body to the thin parylene film deposition on the packaging’s surface.

Airborne metal particles (MPs; particle size > 10 μm) in workplaces result in a loss in production yield if not detected in time. The demand for compact and cost-efficient MP sensors to monitor airborne MP generation is increasing. However, contemporary instruments and laboratory-grade sensors exhibit certain limitations in real-time and on-site monitoring of airborne MPs. This paper presents a microfluidic MP detection chip to address these limitations. By combining the proposed system with microcirculation-based particle-to-liquid collection and a capacitive sensing method, the continuous detection of airborne MPs can be achieved. A few microfabrication processes were realized, resulting in a compact system, which can be easily replaced after contamination with a low-priced microfluidic chip. In our experiments, the frequency-dependent capacitive changes were characterized using MP (aluminum) samples (sizes ranging from 10 μm to 40 μm). Performance evaluation of the proposed system under test-bed conditions indicated that it is capable of real-time and continuous monitoring of airborne MPs (minimum size 10 μm) under an optimal frequency, with superior sensitivity and responsivity. Therefore, the proposed system can be used as an on-site MP sensor for unexpected airborne MP generation in precise manufacturing facilities where metal sources are used.

Growing concerns related to the adverse health effects of airborne ultrafine particles (UFPs; particles smaller than 300 nm) have highlighted the need for field-portable, cost-efficient, real-time UFP dosimeters to monitor individual exposure. These dosimeters must measure both the particle density and size distribution as these parameters are essential to the determination of where and how many UFPs will be deposited in human lungs. However, though various kinds of laboratory-grade instruments and hand-held monitors have been developed, they are expensive and only capable of measuring particle size distribution. A microfluidic UFP dosimeter is proposed in this study to address these limitations. The proposed sensor, based on an electrical detection method with a machine-learning-aided algorithm, can simultaneously measure the size distribution (number concentration, mean mobility diameter, geometric standard deviation) and particle density, and is compact owing to the microelectromechanical systems (MEMS) technology. In a comparison test using physically synthesised Ag and di-ethyl-hexyl sebacate (DEHS) aerosols, the mean measurement errors of the proposed sensor compared to the reference system were 6.1%, 4.5%, and 7.3% for number concentration, mean mobility diameter, and particle density, respectively. Moreover, when the machine-learning aided algorithm was operated, the geometric standard deviation could be deduced with a 7.6% difference. These results indicate that the proposed device can be successfully used as a field-portable UFP sensor to assess individual exposure, an on-site monitor for ambient air pollution, an analysis tool in toxicological studies of inhaled particles, for quality assurance of nanomaterials engineered via aerosol synthesis, etc.

We present a compact and inexpensive detection system that can accurately measure the number concentration of nanoparticles (NPs; particles smaller than 100 nm) in real-time for assessing individual exposure to airborne NPs in various environments. Our system is based on the condensation nucleation light scattering technique and uses water as the condensing liquid, which solves the self-contamination issues that affect most portable NP detection systems. Our system comprises two units: a microfluidic condensation chip for growing NPs into water droplets and a miniature optical detector for singly counting grown droplets. To effectively minimize the size and cost of our system, droplets are grown on a single chip according to the semiconductor manufacturing process. To use water as the condensing liquid, a super-hydrophilic wick (i.e., Cu micropillar array coated with CuO nanowires) is monolithically integrated into the chip. Simulations were performed to verify the method of generating supersaturated water vapor. Quantitative experiments using NaCl and Ag NPs revealed that our system grew NPs larger than 9.3 nm into 2.25 μm diameter water droplets and could count individual droplets over an extremely wide concentration range (0.021–10⁵ N cm⁻³) with high accuracy. This outstanding performance allowed our system to resolve the daily pattern of the NP concentration along a metropolitan commuting street with strong agreement compared to the reference instrument. Because our system uses water, it can accurately monitor individual exposure to NPs in various kinds of environments, including multiuse facilities such as elementary schools and hospitals.

We present a portable, inexpensive, and accurate microelectromechanical-system-based (MEMS-based) condensation particle counter (CPC) for sensitive and precise monitoring of airborne ultrafine particles (UFPs) at a point of interest. A MEMS-based CPC consists of two main parts: a MEMS-based condensation chip that grows UFPs to micro-sized droplets and a miniature optical particle counter (OPC) that counts single grown droplets with the light scattering method. A conventional conductive cooling-type CPC is miniaturized through MEMS technology and three-dimensional (3-D) printing techniques; the essential elements for growing droplets are integrated on a single glass slide. Our system is much more compact (75 mm × 130 mm × 50 mm), lightweight (205 g), and power-efficient (2.7 W) than commercial CPCs. In quantitative experiments, the results indicated that our system could detect UFPs with a diameter of 12.9 nm by growing them to micro-sized (3.1 µm) droplets. Our system measured the UFP number concentration with high accuracy (mean difference within 4.1 %), and the number concentration range for which our system can count single particles is 7.99–6850 cm⁻³. Thus, our system has the potential to be used for UFP monitoring in various environments (e.g., as an air filtration system, in high-precision industries utilizing clean rooms, and in indoor and outdoor atmospheres).