Nitesh Nama

Muscular systems ¹ , the fundamental components of mobility in animals, have sparked innovations across technological and medical fields ^2,3 . Yet artificial muscles suffer from dynamic programmability, scalability and responsiveness owing to complex actuation mechanisms and demanding material requirements. Here we introduce a design paradigm for artificial muscles, utilizing more than 10,000 microbubbles with targeted ultrasound activation. These microbubbles are engineered with precise dimensions that correspond to distinct resonance frequencies. When stimulated by a sweeping-frequency ultrasound, microbubble arrays in the artificial muscle undergo selective oscillations and generate distributed point thrusts, enabling the muscle to achieve programmable deformation with remarkable attributes: a high compactness of approximately 3,000 microbubbles per mm ² , a low weight of 0.047 mg mm ⁻² , a substantial force intensity of approximately 7.6 μN mm ⁻² and fast response (sub-100 ms during gripping). Moreover, they offer good scalability (from micrometre to centimetre scale), exceptional compliance and many degrees of freedom. We support our approach with a theoretical model and demonstrate applications spanning flexible organism manipulation, conformable robotic skins for adding mobility to static objects and conformally attaching to ex vivo porcine organs, and biomimetic stingraybots for propulsion within ex vivo biological environments. The customizable artificial muscles could offer both immediate and long-term impact on soft robotics, wearable technologies, haptics and biomedical instrumentation.

Disturbed flow is a hallmark of diseased vasculature, yet its influence on particle behavior under external actuation remains poorly understood. We uncover distinct behaviors of microparticles under disturbed flow when exposed to ultrasound, revealing selective trapping and aggregation phenomena that differ fundamentally between soft and rigid particles. Using microfluidic models of disturbed vascular flow, we show that microbubbles become trapped at the eye of vortices and self-assemble via ultrasound-induced forces. As clusters grow to a critical size, they are ejected and adhere to the wall opposite the ultrasound source, forming nuclei that progressively occupy aneurysm cavities—a mechanism that could enable targeted, noninvasive treatment. These findings reveal an unexplored interplay between ultrasound and hydrodynamic forces, offering a new strategy for ultrasound-guided therapeutic delivery in vascular disease. One-Sentence Summary: Vortices are common in diseased arteries, yet we don’t know how therapeutic carriers behave in them under ultrasound. We discover that microbubbles self-assemble in vortex cores, then eject and anchor to vessel walls—revealing a new transport regime with therapeutic potential.

We present a numerical model to study time-averaged acoustic radiation force and microstreaming around an elastic sphere immersed within an acoustically actuated viscoelastic fluid. We employ a perturbation approach to systematically identify limiting regimes where the viscoelastic fluid can be approximated as a purely viscous fluid at the acoustic and mean time scales. Unlike existing numerical models, we account for microstreaming and fluid elasticity contributions to the radiation force. We elucidate the inherent assumptions within reduced expressions considered in prior numerical models and highlight the divergence between the acoustic radiation force obtained from the reduced and general expressions. We also discuss numerical considerations to ensure the invariance of the acoustic radiation force with the choice of integration surface by recasting the time-averaged mass balance equation in terms of Stokes drift. Our results reveal that the acoustic radiation force exhibits a peak value for an optimal relaxation time, and both the peak acoustic radiation force and the optimal relaxation time increase with increasing polymer viscosity. The results also highlight the significant contribution of fluid elasticity to the radiation force and invalidate the previously employed reduced acoustic radiation force expressions for general viscoelastic regime.

We present a numerical study to investigate the efficacy of impedance boundary conditions in capturing the interfacial dynamics of a particle subjected to an acoustic field and study the concomitant time-averaged acoustic streaming and radiation force fields. While impedance boundary conditions have been utilized to represent fluid–solid interface in acoustofluidics, such models assume the solid material to be locally reactive to the acoustic waves. However, there is a limited understanding of when this assumption holds true, raising concerns about the suitability of impedance boundary conditions. Here, we systematically investigate the applicability of impedance boundary conditions by comparing the predictions of an impedance boundary approach against a fully coupled fluid–solid model. We contrast the oscillation profiles of the fluid–solid interface predicted by the two models. We consider different scatterer materials to identify the extent to which the differences in interfacial dynamics impact the time-averaged fields and highlight the divergence within the predictions of the two models. Our findings indicate that, although impedance boundary conditions can yield qualitatively similar results to the full model in certain situations, the predictions from the two models generally differ both qualitatively and quantitatively. These results underscore the importance of exercising caution when applying these boundary conditions to model general acoustofluidic systems.

When a fluid system is subjected to an acoustic wave (or another periodic actuation), the response of the fluid is not purely periodic, but is rather characterized by the combination of a periodic flow and a steady Stokes drift component, where the former is, in many cases, an acoustic wave and the latter is commonly referred to as acoustic streaming. Classical theories of acoustic streaming have focused on slow acoustic streaming, where the periodic flow is the leading-order flow, and is insensitive to the steady flow component which appears as a small correction and is characterized by a small hydrodynamic Reynolds number. In contrast, Dubrovski et al. (J. Fluid Mech. vol. 975, 2023, A4) tackle the fast acoustic streaming regime – conceived by Zarembo (Acoustic streaming. In High-Intensity Ultrasonic Fields, 1971, pp. 135–199. Springer) approximately fifty years ago – where both the periodic and steady flow components are of a similar order of magnitude such that the periodic flow both supports and is simultaneously impacted by the steady flow. They present a novel theoretical framework that accounts for the convection of momentum both within and between the periodic and steady flow to extend slow-streaming equations to the case of steady flow with arbitrary hydrodynamic Reynolds number. They leverage a scaling analysis of the resulting system of equations and a case study to demonstrate the compatibility of their equations with slow streaming theories and highlight the distinctive features of fast streaming.

Soft polymeric microrobots that can be loaded with nanocargoes and driven via external field stimuli can provide innovative solutions in various fields, including precise microscale assembly, targeted therapeutics, microsurgery, and the capture and degradation of unwanted wastewater fragments. However, in aquatic environments, it remains challenging to operate with microrobotic devices due to the predominant viscous resistances and the robots’ limited actuation and sensing capabilities attributed to their miniaturization. The miniature size prevents the incorporation of onboard batteries that can provide sufficient power for propulsion and navigation, necessitating a wireless power supply. Current research examines untethered microrobot manipulation using external magnetic, electric, thermodynamic, or acoustic field-guided technologies: all strategies capable of wireless energy transmission towards sensitive and hard-to-reach locations. Nonetheless, developing a manipulation strategy that harnesses simple-to-induce strong propulsive forces in a stable manner over extended periods of time remains a significant endeavor. This study presents the fabrication and manipulation of a microrobot consisting of a magnetized soft polymeric composite material that enables a combination of stable acoustic propulsion through starfish-inspired artificial cilia and magnetic field-guided navigation. The acousto-magnetic manipulation strategy leverages the unique benefits of each applied field in the viscous-dominated microscale, namely precise magnetic orientation and strong acoustic thrust.

Acoustofluidic systems often employ prefabricated acoustic scatterers that perturb the imposed acoustic field to realize the acoustophoresis of immersed microparticles. We present a numerical study to investigate the time-averaged streaming and radiation force fields around a scatterer. Based on the streaming and radiation force field, we obtain the trajectories of the immersed microparticles with varying sizes and identify a critical transition size at which the motion of immersed microparticles in the vicinity of a prefabricated scatterer shifts from being streaming dominated to radiation dominated. We consider a range of acoustic frequencies to reveal that the critical transition size decreases with increasing frequency; this result explains the choice of acoustic frequencies in previously reported experimental studies. We also examine the impact of scatterer material and fluid properties on the streaming and radiation force fields, as well as on the critical transition size. Our results demonstrate that the critical transition size decreases with an increase in acoustic contrast factor: a nondimensional quantity that depends on material properties of the scatterer and the fluid. Our results provide a pathway to realize radiation force based manipulation of small particles by increasing the acoustic contrast factor of the scatterer, lowering the kinematic viscosity of the fluid, and increasing the acoustic frequency.