Adnan Salim Abu-Surrah

Palladium(II) ( 1A – 4A ) and platinum(II) ( 1B , 2B, and 4B ) complexes bearing biphosphine ligands with different backbones and variable substituents on the phosphine donor atoms were prepared and characterized. Molecular docking of the complexes was performed. In silico analysis was performed to predict the “drug‐likeness” and ADMET properties. The in vitro cytotoxicity of these complexes against colorectal (HCT‐116), hepatocellular (HepG2), and breast (MCF‐7) cancer cells was also evaluated. The docking results demonstrated that all complexes exhibit good binding affinity to B‐DNA. Some of the Pd(II) complexes showed acceptable cytotoxic effects compared to cisplatin. Overall, the neutral palladium(II) complexes with the selected biphosphine ligands displayed better cytotoxicity than their corresponding Pt(II) analogues. Among them, the Pd(II) complex 4A , bearing the biphosphine ligand with bulky aliphatic axial substituents and a reduced bite angle, showed the highest DNA‐binding affinity and excellent cytotoxic activity (IC ₅₀ = 14.2 µM against the MCF‐7 cancer cell line) compared to cisplatin (IC ₅₀ = 31.3 µM) and the corresponding Pt(II) complex 4B (IC ₅₀ = 132.9 µM). In addition, complex 4A demonstrated exceptional antitumor selectivity (selectivity index value of 9.5) as compared to that of cisplatin (SI = 1.3). Since the electronic, structural, and chiral properties of these ligands can be easily turned, Pd(II) complexes with large aliphatic axial substituents biphosphine ligands (such as complex 4A ) may represent a promising alternative for cancer treatment.

In this study, we synthesized a series of PPh₃‐substituted diiron complexes with the general formula [Fe₂(CO)₅PPh₃{μ‐S(CH₂)_nS}] (n = 4 (1), 5 (2), 7 (3), 8 (4)), bearing structural similarities to the active site of [FeFe]‐hydrogenase. These complexes were derived from their parent analogues, [Fe₂(CO)₆{μ‐S(CH₂)_nS}] (n = 4, 5, 7, 8), through ligand substitution. Their formation was verified through a combination of spectroscopic methods, elemental analysis, and X‐ray crystallography, confirming their structural integrity and composition. Moreover, we examined how the PPh₃ ligand and the varying lengths of the dithiolato linker in complexes 1–4 affect their redox properties and catalytic performance. Using cyclic voltammetry, we evaluated their electrochemical behavior and proton reduction activity in the presence of acetic acid (AcOH). Consequently, the reduction potential shifts of complexes 1–4, in comparison to their precursors, followed the sequence: 3 > 2 > 1 > 4. Furthermore, at the highest AcOH concentration established, complex 3 demonstrates the most significant current enhancement (i_cat/i_p = 26.2). In comparison, complexes 1, 2, and 4 exhibit relatively similar i_cat/i_p values of 13.6, 13.0, and 11.9, respectively.

A first-time, end group thermolysis departing a urethane into propylene carbonate. This exposure produced a new amine tethering point producing a diamine-terminated oligourea ([10]-OU) as a green sorbent for CO ₂ capturing is reported.

The synthesis of new palladium(II) complexes of the type [Pd(A–NC–ph–CN–A)Cl2] (4a–e) (A=cyclohexyl (a), 2-isoprpropyl (b), pyrenyl (c), naphthyl (d), and 2,6-diisopropyl (e)) is described. The isolated γ-diimine ligands and their corresponding palladium(II) complexes were characterized by their physical properties, elemental analysis, 1H NMR-, 13C NMR, and infrared spectroscopy. The palladium(II) complexes (4a–e) were employed successfully as catalysts for atom transfer radical polymerization (ATRP) of methyl methacrylate (MMA) in the presence of ethyl-2-bromoisobutyrate (EBIB) as initiator at 90°C. Polymerization with these catalyst systems afforded polymers with low molecular weight distribution (Mw/Mn) and syndio-rich atactic poly (MMA) with relatively higher [rr] diads

A series of azoimine palladium(II) complexes of the general type cis-[PdCl2L] (1–6) {L=PhNNC(COMe)NC6H4X, where X=H (L1), CH3 (L2), Cl (L3), Br (L4), naphthyl (L5) and OMe (L6)} have been prepared by the reaction of cis-[PdCl2(NCPh)2] and the ligands (L) in acetone at room temperature. These complexes have been characterized by spectroscopic (IR-, UV–Vis and NMR) and electrochemical techniques. In addition, their biological activity has been studied via MTT test and by detecting the inhibition of clonal growth in three tumor cell lines, namely T47D human ductal breast carcinoma, MTLn3 murine mammary adenocarcinoma and RAW 264.7 murine leukemic monocyte macrophage. All of the tested palladium(II) complexes showed a noticeable antitumor activity. Complexes 4 and 5 showed a higher cytotoxic activity against human T47D breast tumor cell line than cisplatin, while comparable activity was observed against murine mammary MTLn3 adenocarcinoma cell line

cis-Dichloro-palladium(II) andcis-dichloro-platinum(II) complexes (2,4) of the general formula [M(N-N)Cl₂] (M=Pd(II) and Pt(II), N-N= 1,2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl) benzene, (DFMPB)) and the dicationic palladium(II) complex [Pd(N-N)(CH₃CN)₂](BF₄)₂(3) have been prepared and characterized by elemental analysis,¹H-NMR-, mass spectroscopy, and IR spectroscopy. The cytotoxic effect of these complexes against MDA-231 and MCF-7 human breast cancer cell lines and K562 human leukemia cell line has been studied. The influence was dose dependent and varies with cell type. The palladium(II) complex (2) showed superior cytotoxic effect compared with the corresponding platinum(II) complex and the standard, cisplatin, when tested against all the above cell lines.

Impedance spectroscopy was utilized to investigate the dielectric properties, ac conductivity and charge transport mechanisms in propylene-alt-CO/ethylene-alt-CO (EPEC) random terpolymer filled with multi-walled carbon nanotubes (MWCNT) as a function of nanofiller content, frequency, and temperature. Equivalent resistor-capacitor (RC) circuit models were proposed to describe the impedance characteristics of the unfilled terpolymer and the nanocomposite at different temperatures. For the nanocomposites, the ac conductivity tended to be frequency independent at low frequencies. At high frequencies, the ac conductivity increased with frequency. The dc conductivity (i.e., plateau of the ac conductivity at low frequencies) at room temperature increased from 10⁻⁹ (Ω·m)⁻¹ for the unfilled polymer to l0⁻³ (Ω·m)⁻¹ for the 6 wt% MWCNT/EPEC nanocomposite. At low temperatures, the equivalent RC model for EPEC-0 and EPEC-2 was found to consist of a parallel RC circuit. However, for 6 wt% MWCNT/EPEC nanocomposite, an RC model consisting of an R/constant phase element (CPE) circuit and a resistor in series was required to describe the impedance behavior of the nanocomposite.