Soodeh Razeghi Jahromi

Background: Migraine, a prevalent neurological condition, is recognized as the sixth leading cause of global disability. The proposed mechanism involves a combination of diminished energy reserves and heightened sensory stimulation activating the trigeminovascular system. Thiamine, essential for energy generation in various tissues including the nervous system, is hypothesized to be involved. This study aims to examine the effects of administering a high dose of thiamine to women with episodic migraine. Methods: A randomized, controlled clinical trial was conducted involving 40 women with episodic migraine. Participants were divided into two groups: one receiving 990 milligrams of thiamine three times daily, and the other receiving 990 milligrams of maltodextrin over 12 weeks. Headache frequency, duration, severity, and disability were evaluated through questionnaires. Initial and final measurements of serum calcitonin gene-related peptide (CGRP) were taken.Results: Thiamine supplementation resulted in a significant reduction in Migraine Disability Assessment (MIDAS) scores, migraine frequency, duration, and intensity compared to the placebo group. However, both groups experienced a decline in serum CGRP levels, with no significant difference between them. Conclusion: This study suggests that high-dose thiamine supplementation may offer a beneficial adjunctive treatment for episodic migraine. Further investigations with prolonged intervention periods are necessary to validate these findings.

Background This study was conducted to assess the association between lifestyle risk factors (LRF) and odds of binge eating disorder (BED) 2 years post laparoscopic sleeve gastrectomy (LSG) using lifestyle score (LS) and machine learning (ML) models. Methods In the current study, 450 individuals who had undergone LSG 2 years prior to participation were enrolled. BED was assessed using BES questionnaire. The collected data for LRF included smoking, alcohol consumption, physical activity (PA), fruit and vegetable intake, overweight/obesity, and percentage excess weight loss (EWL%). ML models included: logistic regression (LG), KNN, decision tree (DT), random forest (RF), SVM, XGBoost, and deep learning or artificial neurol network (ANN). Additionally, accumulative LRF was assessed using LS. Results One hundred and twenty-two subjects (26.1%) met the criteria for BED 2 years after LSG. Participants who were in the highest quartile of the lifestyle score (nearly worst) had significantly three times higher odds of BED compared to the lowest quartile (nearly optimal) (p trend = 0.01). Furthermore, RF, LG, SVM, and ANN had the highest accuracy (about 75%) in predicting BED compared to other ML models (between 60 and 72%). Among the lifestyle risk factors, insufficient PA, lower vegetable consumption, a higher level of BMI, and lower EWL% were independently associated with BED (p < 0.05). Conclusions Our findings indicate that poor lifestyle patterns are associated with the development of BED, in contrast to non-BED individuals. Given the prevalence of this disorder among LSG participants, lifestyle risk factors must receive special attention after BS.

Background This study examined the presence of food addiction (FA) in patients with binge eating disorder (BED) 2 years after laparoscopic sleeve gastrectomy (LSG) and explored its association with some minerals, ferritin, weight loss and, body composition outcomes. Materials and Methods In this study, 120 patients with BED who had undergone LSG 2 years prior to participation were enrolled. BED was assessed using Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria and presence of FA was assessed using the Yale Food Addiction Scale (YFAS). The collected data included general characteristic, food intake, physical activity, weight loss percentage, body composition measurements such as fat mass (FM) and fat-free mass (FFM), as well as serum level of magnesium, zinc, iron, and ferritin. Results Fifty individuals with BED met the criteria for FA disorder (41.66%). BED patients who had FA had significantly higher weight (P = 0.01) compared to those without FA. Regarding body composition changes, the finding reveals that patients with BED + FA (vs. only-BED) had a significantly lower FM loss percentage (p = 0.04) and higher FFM loss percentage (p = 0.04). The BED patients with FA had significantly lower levels of magnesium (p = 0.02) and a higher level of ferritin (p = 0.04) compared to those without FA at second year after LSG. Conclusion The presence of FA in patients with BED was associated with higher weight, poor body composition outcomes, lower serum level of magnesium, and higher ferritin two years post-LSG surgery.

Migraine headaches are the most prevalent disabling primary headaches, affecting individuals at an active age. Dietary interventions are considered low‐cost and practical approaches to migraine prophylaxis. Hence, the present study aimed to assess the association between adherence to the Healthy Eating Index 2015 (HEI‐2015) and migraine headaches. The present case–control study was conducted on 476 newly diagnosed adults with migraine headaches, based on the International Classification of Headache Disorders 3rd edition (ICHDIII criteria(, and 512 healthy controls. Participants' dietary intakes were collected using a validated, 168‐item semi‐quantitative food frequency questionnaire (FFQ). The association between HEI‐2015 and migraine headaches was assessed using logistic regression models. Although the trend was not statistically significant, being in the 4th quantile of the HEI‐2015 was associated with about 50% lower odds of migraine headaches in both primary (adjusted for age and gender) (odds ratios (OR): 0.51, 95% confidence intervals (CI): 0.33, 0.78) and fully adjusted models (additionally adjusted for body mass index (BMI) and total calories) (adjusted OR: 0.50, 95%CI: 0.32, 0.77). Intriguingly, the odds of migraine headaches were significantly higher in those in the last quantile of “Total Fruits,” which is equal to more than 237 g per 1000 kcal (aOR: 2.96, 95%CI: 1.99, 4.41) and “Whole Fruits,” which is equal to more than 233 g per 1000 kcal (aOR: 2.90, 95%CI: 1.94, 4.31). Similarly, higher intakes of “Dairy,” which is equal to more than 138 g per 1000 kcal (aOR: 2.66, 95%CI: 1.71, 4.14), and “Total Protein Foods,” which is equal to more than 259 g per 1000 kcal (aOR: 2.41, 95%CI: 1.58, 3.70), were associated with higher odds of migraine headaches. The current study revealed an indirect association between HEI‐2015 and its components, including “Greens and Beans,” “Whole Grains,” “Refined Grains,” and “Added Sugars” and lower odds of migraine headaches.

Purpose To evaluate the effect of a low-calorie dietary approach to stop hypertension (DASH) compared to a low-calorie diet on weight control, body composition and glycemic measures in post sleeve patients with weight regain. Materials and Methods Participants were randomly allocated to either the low-calorie DASH diet group (intervention) or the low-calorie diet group (control) for a duration of 16 weeks. Both groups had a prescribed caloric intake of 1000–1200 calories. The DASH diet group made dietary adjustments in accordance with the DASH pattern. Results At the end of the study, both interventions significantly reduced anthropometric and body composition parameters (P-value < 0.001), with a greater decrease observed in the low-calorie DASH diet group (P-value < 0.001). Insulin levels and homeostatic model assessment for insulin resistance (HOMA-IR) decreased significantly in both groups, but the magnitude of these changes was not statistically different between the two groups. After adjusting for confounders, a significant difference was observed in post-intervention values and changes in weight, body mass index, and fat mass and fat-free mass. Conclusion In summary, adhering to a calorie-restricted DASH diet for 16 weeks improved weight loss, body mass index, and fat mass reduction in post-bariatric patients who experienced weight regain 2 years after surgery, compared to a calorie-restricted control diet. However, there was no significant difference in the effect on blood glucose, insulin, and HOMA-IR between the two diets. Graphical Abstract

The prevalence of cognitive impairment in multiple sclerosis (MS) patients is estimated to be approximately 40–60%. There is an increasing body of evidence regarding the impact of both selenium and crocin as antioxidant agents on cognitive function. In the present study, for the first time, we investigated the effect of crocin-selenium nanoparticles (Cor@SeNs) on cognitive function and oxidative stress markers in MS patients. A triple-blind randomized clinical trial was conducted among 60 MS patients. The participants were randomly divided in a 1:1 ratio to either the Cor@SeNs or placebo group, employing block randomization. During the course of 12 weeks, the participants received Cor@SeNs capsules, containing 5.74 mg crocin and 55 mcg Selenium, or placebo capsules. Cognition assessed using the Persian version of the Brief International Cognitive Assessment for MS (BICAMS) battery. Serum levels of total antioxidant capacity (TAC), glutathione reductase (GR) activity and malondialdehyde (MDA) determined by colorimetric kits. Data analysis was performed in SPSS, version 26. P < 0.05 was considered as the significant range. The mean ± SD of TAC change was 0.03 ± 0.07 mM vs. − 0.03 ± 0.09 mM in intervention and placebo groups, respectively (Time × group effect P: 0.01; effect size: 0.10). The time effect of intervention on the California Verbal Learning Test second edition (CVLT-II) (P < 0.01; effect size: 0.29), CVLT-II-delay (P < 0.01; effect size: 0.29), and the Symbol Digit Modalities Test (SDMT) (P < 0.01; effect size: 0.18) was increasing and significant. In addition, the time effect of intervention on GR activity was significant and decreasing in both groups (P < 0.01; effect size: 0.20). Our results suggested a significant effect of the Cor@SeNs intervention in improving TAC. We also observed a significant improvement in cognitive function in both groups during our study. However, although not statistically significant, a higher amount of change in cognitive function and serum antioxidant markers was noted in the Cor@SeNs group compared to the placebo group. This is the first study on this nano product with low dose of selenium and crocin. More investigations with longer duration and varied doses are suggested.