Mu-Hyoung Lee

Kim TE, et al. J Korean Med Sci. 2022 Apr;37(14):e110. https://doi.org/10.3346/jkms.2022.37.e110

Seo JK, et al. Ann Dermatol. 2020 Dec;32(6):516-518. https://doi.org/10.5021/ad.2020.32.6.516

Background: Laser therapy can be used as an alternative treatment for onychomycosis; however, there are some limitations to its efficacy as a single agent. Objective: To evaluate the effectiveness of combination therapy with 1,064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser and topical efinaconazole in onychomycosis treatment and identify factors influencing the therapeutic outcomes of combination treatment. Methods: Big toenails with onychomycosis were treated by 1,064-nm Nd:YAG laser at 4-week intervals with daily application of topical efinaconazole. Therapeutic response was assessed through onychomycosis severity index (OSI) and percentage of nail infected (PNI), and its association with a variety of factors that may affect treatment outcome was evaluated. Results: One hundred big toenails were included in the study and significant clinical improvements were observed after treatment (OSI improvement score = 76.68 ± 28.83, PNI improvement score = 72.37 ± 30.37). There was no difference in treatment response according to the number of laser treatments, onychomycosis clinical type, or initial severity. However, patient age was negatively correlated with clinical improvement (p = 0.019). Also, female patients had better therapeutic responses than male patients. Conclusion: Combined treatment with Nd:YAG laser and topical efinaconazole has a significant therapeutic effect on onychomycosis. A randomized controlled trial is warranted in the future.

Park HJ, et al. Ann Dermatol. 2019 Feb;31(1):90-92. https://doi.org/10.5021/ad.2019.31.1.90

A 13‐year‐old Korean girl presented with a 7‐year history of a pruritic, light‐brown patch containing multiple 0.2‐ to 0.5‐cm brownish‐to‐reddish maculopapules on the left anterior chest. When her skin was rubbed, the lesion became itchy and red. Histopathologic evaluation demonstrated marked dense dermal infiltration of mast cells. We report a rare case of atypical maculopapular cutaneous mastocytosis with clinical features similar to those of nevus spilus.

Shin EJ, et al. Ann Dermatol. 2018 Apr;30(2):249-251. https://doi.org/10.5021/ad.2018.30.2.249