Jorge Acosta-Reyes

The aim of this systematic review/meta-analysis of randomized clinical trials (RCTs) was to determine the efficacy of sucrose or glucose (SG) in preterm infants requiring heel lancing and venipuncture compared to breast milk or expressed breast milk (BM/EBM) for pain control and crying duration. Six RCTs (525 infants) comparing sucrose (24%) or glucose (30%, 10%, 25%) with BM/EBM were included. There was no difference between the alternatives in pain reduction at 30 s post-procedure measured with the Premature Infant Pain Profile (PIPP/PIPP-R) scores (MD -0.95, 95% CI −2.43; 0.54, Low certainty evidence). SG reduced the crying duration (MD –6.88, 95%CI −11.42; −2.34, Moderate certainty evidence). There were no differences between SG and BM/EBM in heart rate change or adverse events. In conclusion, moderate certainty evidence suggests that SG may be superior to BM/EBM for reducing crying duration during heel lancing and venipuncture procedures, but not for reducing pain intensity measured with PIPP/PIPP-R. Objective: To determine the efficacy of sucrose or glucose (SG) in preterm infants requiring heel lancing and venipuncture compared to breast milk or expressed breast milk (BM/EBM) for pain control and crying duration. Study design: Systematic review and meta-analysis of randomized clinical trials. Results: Six RCTs (525 infants) comparing sucrose (24%) or glucose (30%, 10%, 25%) with BM/EBM. There was no difference between the alternatives in pain reduction at 30 s post-procedure measured with the Premature Infant Pain Profile (PIPP/PIPP-R) scores (MD −0.95, 95% CI −2.43; 0.54, Low certainty evidence). SG reduced the crying duration (MD –6.88, 95%CI −11.42; −2.34, Moderate certainty evidence). There were no differences between SG and BM/EBM in heart rate change or adverse events. Conclusions: Moderate certainty evidence suggests that SG may be superior to BM/EBM for reducing crying duration during heel lancing and venipuncture procedures, but not for reducing pain intensity measured with PIPP/PIPP-R.

The Appraisal of Guidelines for Research and Evaluation II Instrument (AGREE II) was developed to enhance the methodological rigor of clinical practice guidelines (CPGs), aiming to generate trustworthy recommendations for various clinical scenarios. Despite its importance, there exists a gap in the quality of CPGs pertaining to Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS-TEN). The aim of the study was to evaluate SJS-TEN CPGs to shed light on areas for enhancing SJS-TEN guidelines' quality. A systematic review was conducted to identify SJS-TEN CPGs from January 2011 to December 2023 across bibliographic and guideline databases, as well as dermatology association websites. Four reviewers employed the AGREE II instrument to appraise the quality of eligible CPGs. Subsequently, AGREE II domain scores were calculated and their recommendations mapped. Seven eligible SJS-TEN CPGs reviewed, originating from Europe, North America, Asia, and an authorship Group. The highest AGREE II domain scores were observed in scope and purpose (mean: 63%, standard deviation [SD]: 23.195%) and clarity of presentation (mean: 70%, SD: 14.5%). Conversely, the lowest score was noted in the applicability domain (mean: 28%, SD: 17.44%). Only two guidelines by the British Association of Dermatologists (28.6%) met the 'recommend' level. Recommendations from all CPGs were compared in tabular form.

Background: Colombia is currently the world’s main recipient country for Venezuelan migrants, and women represent a high proportion of them. This article presents the first report of a cohort of Venezuelan migrant women entering Colombia through Cúcuta and its metropolitan area. The study aimed to describe the health status and access to healthcare services among Venezuelan migrant women in Colombia with irregular migration status, and to analyze changes in those conditions at a one-month follow-up. Methods: We carried out a longitudinal cohort study of Venezuelan migrant women, 18 to 45 years, who entered Colombia with an irregular migration status. Study participants were recruited in Cúcuta and its metropolitan area. At baseline, we administered a structured questionnaire including sociodemographic characteristics, migration history, health history, access to health services, sexual and reproductive health, practice of early detection of cervical cancer and breast cancer, food insecurity, and depressive symptoms. The women were again contacted by phone one month later, between March and July 2021, and a second questionnaire was applied. Results: A total of 2,298 women were included in the baseline measurement and 56.4% could be contacted again at the one-month follow-up. At the baseline, 23.0% of the participants reported a self-perceived health problem or condition in the past month and 29.5% in the past 6 months, and 14.5% evaluated their health as fair or poor. A significant increase was found in the percentage of women who reported a self-perceived health problem during the past month (from 23.1% to 31.4%; p<0.01); as well as in the share who reported moderate, severe, or extreme difficulty working or performing daily chores (from 5.5% to 11.0%; p = 0.03) and who rated their health as fair (from 13.0% to 31.2%; p<0.01). Meanwhile, the percentage of women with depressive symptoms decreased from 80.5% to 71.2% (p<0.01). Conclusion: This report presents initial information on the health status of Venezuelan migrant women in Colombia, and is a starting point for further longer longitudinal follow-ups to assess changes over time in health conditions.

Background Colombia is currently the world’s main recipient country for Venezuelan migrants, and women represent a high proportion of them. This article presents the first report of a cohort of Venezuelan migrant women entering Colombia through Cúcuta and its metropolitan area (the main land entry point to this country). The study aimed to describe the health status and access to healthcare services among Venezuelan migrant women in Colombia with irregular migration status, and to analyze changes in those conditions at a one-month follow-up. Methods A longitudinal cohort study of Venezuelan migrant women, 18 to 45 years, who entered Colombia with an irregular migration status, was carried out in 2021. Study participants were recruited in temporary shelters, transit points, and migrant settlements in Cúcuta and the metropolitan area. At baseline, we administered a structured questionnaire including sociodemographic characteristics, migration history, health history, access to health services, sexual and reproductive health, practice of early detection of cervical cancer and breast cancer, food insecurity, and depressive symptoms. The women were again contacted by phone one month later, between March and July 2021, and a second questionnaire was applied. Results A total of 2,298 women were included in the baseline measurement and 56.4% could be contacted again at the one-month follow-up. A significant increase was found in the percentage of women who had a health problem during the past month (from 23.1% to 31.4%; pConclusion This report is a starting point for the longitudinal follow-up of the cohort, which will allow us to better understand how the health status of Venezuelan women changes during the migration flow in Colombia.