Mustapha Allali

Corrosion resistance and adsorption attributes of three synthesized dihydroimidazoles, namely (4R,5S)-2,4,5-tris(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-imidazole (TMPI), (4R,5S)-2,4,5-tris(4-(methylthio)phenyl)-4,5-dihydro-1H-imidazole (MSPI), and (4S,5R)-2,4,5-tri(thiophen-2-yl)-4,5-dihydro-1H-imidazole (TTPI), were scrutinized for carbon steel in 1 M HCl employing a combination of analytical techniques, including electrochemical and instrumental, alongside quantum computational methods. Electrochemical experiments revealed that the effectiveness of corrosion inhibition is influenced by the substituted dihydroimidazoles' concentration and structure. The inhibition efficiency reached remarkable levels: 98.53% for TTPI, 98.59% for TMPI, and 99.12% for MSPI at 0.001 M. The Tafel polarization method indicated that these synthesized dihydroimidazoles function as mixed-type inhibitors. The adsorption process of synthesized dihydroimidazoles adheres to the Langmuir adsorption isotherm. Various analytical techniques, including scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), contact angle, atomic force microscopy (AFM), and X-ray diffraction analysis (XRD), confirmed that substituted dihydroimidazoles form a protective layer that inhibits carbon steel dissolution. Furthermore, molecular dynamics (MD) was utilized to investigate the adsorption behavior of substituted dihydroimidazoles on the Fe (110) surface, determining the entanglement order of their interaction. The radial distribution function (RDF) revealed that corrosion inhibitors employ a complex adsorption mechanism on metal surfaces, primarily driven by chemical processes and supplemented by physical adsorption.

A reforma das práticas profissionais nas ciências da enfermagem para atender às crescentes demandas do cenário da saúde exige equipar os estudantes de enfermagem com capacidades reflexivas que promovam a autoavaliação e o desenvolvimento pessoal. Essa necessidade é fundamental para aumentar sua motivação e garantir o sucesso acadêmico e profissional. A prática reflexiva (PR) é um componente essencial na profissionalização da educação em enfermagem, servindo como uma ferramenta vital para o desenvolvimento de habilidades, o aumento da motivação e a promoção do crescimento profissional, auxiliando assim na integração harmoniosa dos estudantes em suas funções profissionais. Este estudo examina o impacto da prática reflexiva em 400 estudantes de 23 Institutos Superiores de Profissões de Enfermagem e Técnicas de Saúde (ISPITS) no Marrocos. Utilizando um questionário meticulosamente validado e distribuído via Formulários Google, esta pesquisa quantitativa explora dois objetivos principais: avaliar a influência da prática reflexiva na dinâmica motivacional dos estudantes durante sua formação no ISPITS marroquino e elucidar a ligação entre a motivação gerada pela prática reflexiva e a integração profissional. Os resultados revelam uma correlação convincente entre a prática reflexiva e o aumento da motivação entre estudantes de enfermagem. Análises estatísticas rigorosas demonstram uma forte associação entre a motivação dos alunos, facilitada pela prática reflexiva, e sua integração profissional. Os insights deste estudo estão prontos para informar e aprimorar outros esforços de formação profissional, reconhecendo o papel crucial da prática reflexiva no fomento da motivação por meio de interações experienciais que proporcionam feedback reflexivo sobre a prática profissional. Explorar caminhos de pesquisa semelhantes é promissor para refinar intervenções educacionais e avançar o discurso acadêmico, promovendo, em última análise, a percepção profissional e o sucesso entre os profissionais de enfermagem.

In this work, the effect of a new quinoxaline derivative, 2-phenyl-3-(prop-2-yn-1-yloxy) quinoxaline (PYQX), was evaluated as a corrosion inhibitor for carbon steel (CS) in 1 M HCl electrolyte. Weight loss measurement, atomic absorption spectroscopy, potentio­dynamic polarization, electrochemical impedance spectroscopy, scanning electron microscopy with energy dispersive spectroscopy, and UV-vis spectroscopy were employed to assess the inhibitory activity. The electronic properties of the interaction between the inhibitor molecule and the CS substrate were studied using molecular dynamics (MD) simulation, density functional theory (DFT), and Fukui functions. According to AC impedance experiments, the inhibitor under consideration showed a maximum level of 98.1 % inhibition efficiency at 1 mM and 30 °C. The Langmuir adsorption isotherm model explains the adsorption of PYQX on the CS surface. A slope of 1 denotes a strong molecule-substrate interaction, suggesting that the binding occurs at specific surface locations. To understand the functioning of the adsorption mechanism, various thermodynamic and activation parameters were evaluated. PDP tests demonstrated that PYQX functions as a mixed-type inhibitor. Computational correlations (DFT, MD, and Fukui indices) supported the experimental findings.

Background: Natural resources are key for discovering medicinal compounds. Hence, the objective of this study was to evaluate the immunomodulatory activities of Cucurbita maxima (pumpkin) seeds, a component of Moroccan folk medicine believed to enhance immunity. Methods: We produced three distinct extracts employing ethanol, ethyl acetate, and water as solvents. The immunomodulatory effects of these extracts were assessed on rabbit immune cell proliferation and their functions, including IgG production, cytotoxicity, and phagocytosis. Results: The study findings reveal a significant stimulation in thymocyte proliferation, yielding a remarkable 285.7% response, along with a 146.5% increase in cytotoxicity (MLR) in response to the aqueous extract. Furthermore, there was a notable enhancement in complement activity by 119.9% in response to the aqueous extract, implying the potential of C. maxima to modulate both humoral and cellular immunity. Additionally, both EtOAc and aqueous extracts led to a reduction in macrophage phagocytic function. The assessment of the antibacterial properties of ethanol extract showed greater effectiveness against Bacillus, E. Coli, and Staphylococcus. In a separate analysis, antioxidant activity was gauged through DPPH, FRAP, and ABTS methods. These tests exhibited robust antioxidative effects across all extracts, characterized by higher levels of phenolic and flavonoid content. The FT-IR spectrum indicated the presence of compounds such as triglycerides, sterol esters, phospholipids, and unsaturated fatty acids in the extracts. Conclusion: Collectively, these outcomes prompt the consideration of utilizing the aqueous extract of Cucurbita maxima to strengthen humoral and cellular immunity, as well as lymphocyte toxicity, in various ailments.

Eight novel ligands were prepared from a known symmetric diaza-18-crown-6 (cyclic ligand) and two commercial N,N′-dimethyl-alkyl diamines (acyclic ligands) via the Cu(I)-catalyzed Huisgen dipolar cycloaddition. All C₂-symmetric isolated ligands readily formed stable crystalline 1 : 1-copper(II) complexes with cupric perchlorate. Their structural, electrochemical and physico-chemical properties were fully investigated with the help of X-ray diffraction, cyclic voltammetry, FT-IR, UV-visible, and electron paramagnetic resonance (EPR) spectroscopies. Planar – or nearly planar – arrangement of the two N3-triazole nitrogens and the two tertiary amine pivot nitrogens was found in one single four-coordinated species, in four five-coordinated species, and three six-coordinated species, with one or two solvent molecule(s), or two oxygen atoms of the crown ether, occupying the axial position(s) in the solid sate. The electron-donating or electron-withdrawing effect of the N1-substituent on the triazol was found to influence the Cu(II)/Cu(I) redox potential of all studied complexes in DMF. The EPR-spectrum of cyclic complexes in frozen DMF at 100 K exhibited two mononuclear species, one of them likely promoting the formation of dinuclear species as a minor component, whereas most acyclic complex spectra were quite similar.

The synthesis of tris(2‐thenoyltrifluoroacetonate)lanthanide(III) complexes featuring a diethylaminostyryl‐2,2′‐bipyridine coligand was achieved for lanthanum; the near‐infrared (NIR) emitters neodymium, erbium, and ytterbium; and the transition‐metal yttrium. The photophysical properties were thoroughly studied, and it was demonstrated that the conjugated bipyridine ligand acts as a good antenna for the sensitization of the NIR emitters. The two‐photon absorption (TPA) properties of all five complexes were investigated by using both two‐photon excited fluorescence and the Z‐scan method. We demonstrate that the nature of the rare earth ion has almost no influence on the TPA properties centered on the conjugated bipyridyl ligand. Finally, we show that Yb^III is sensitized by a two‐photon antenna effect, and that Nd^III is mostly sensitized by a one‐photon process involving direct excitation of forbidden f–f transitions.

Two europium complexes with bis(bipyridine) azamacrocyclic ligands featuring pendant arms with or without π-conjugated donor groups are synthesized and fully characterized by theoretical calculations and NMR spectroscopy. Their photophysical properties, including two-photon absorption, are investigated in water and in various organic solvents. The nonfunctionalized ligand gives highly water-stable europium complexes featuring bright luminescence properties but poor two-photon absorption cross sections. On the other hand, the europium complex with an extended conjugated antenna ligand presents a two-photon absorption cross section of 45 GM at 720 nm but is poorly luminescent in water. A detailed solvent-dependent photophysical study indicates that this luminescence quenching is not due to the direct coordination of O–H vibrators to the metal center but to the increase of nonradiative processes in a protic solvent induced by an internal isomerization equilibrium.