UCUphar Chamoli

Uphar Chamoli

*This is an algorithmically generated author record based on publicly available information.

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Previous Organizations / Institutes

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Uphar Chamoli has a total of 59 co-authors. Here are the top co-authors by number of shared publications:

  • Ashish Dhar Diwan

    Spine Labs, St George and Sutherland Clinical School, University of New South Wales, Sydney, Australia

    12 shared publications
  • Ashish D. Diwan

    Department of Orthopaedic Surgery, Spine Service, St. George & Sutherland Clinical School, University of New South Wales Australia, Kogarah, Sydney, New South Wales, Australia

    8 shared publications
  • Stephen Wroe

    University of New England

    8 shared publications
  • Phillip D. Clausen

    School of Engineering, University of Newcastle, Callaghan, NSW 2308, Australia

    4 shared publications
  • Daniel Chepurin

    Department of Orthopaedic Surgery, Spine Service, St. George & Sutherland Clinical School, University of New South Wales Australia, Kogarah, Sydney, New South Wales, Australia

    3 shared publications
  • Vivek Ananda Sunil Ramakrishna

    School of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, Kensington, New South Wales, Australia; Spine Labs, St. George & Sutherland Clinical School, University of New South Wales, Sydney, New South Wales, Australia; School of Engineering, Faculty of Science and Engineering, Macquarie University, Sydney, New South Wales, Australia

    3 shared publications

Latest Publications

  • Open Access

    Intrinsic variables associated with low back pain and lumbar spine injury in fast bowlers in cricket: a systematic review

    by Patrick Farhart, David Beakley, Ashish Diwan, Rob Duffield, Elizabeth Pickering Rodriguez, Uphar Chamoli, Mark Watsford

    Background: Lumbar spine injuries in fast bowlers account for the greatest missed playing time in cricket. A range of extrinsic and intrinsic variables are hypothesised to be associated with low back pain and lumbar spine injury in fast bowlers, and an improved understanding of intrinsic variables is necessary as these may alter load tolerance and injury risk associated with fast bowling. This review critically evaluated studies reporting intrinsic variables associated with low back pain and lumbar spine injury in fast bowlers and identified areas for future investigation. Methods: OVID Medline, EMBASE, SPORTDiscus, CINAHL, Web of Science and SCOPUS databases were last searched on 3 June 2022 to identify studies investigating intrinsic variables associated with low back pain and lumbar spine injury in cricket fast bowlers. Terms relevant to cricket fast bowling, and intrinsic variables associated with lumbar spine injury and low back pain in fast bowlers were searched. 1,503 abstracts were screened, and 118 full‐text articles were appraised to determine whether they met inclusion criteria. Two authors independently screened search results and assessed risk of bias using a modified version of the Quality in Prognostic Studies tool. Results: Twenty-five studies met the inclusion criteria. Overall, no included studies demonstrated a low risk of bias, two studies were identified as moderate risk, and twenty-three studies were identified as high risk. Conflicting results were reported amongst studies investigating associations of fast bowling kinematics and kinetics, trunk and lumbar anatomical features, anthropometric traits, age, and neuromuscular characteristics with low back pain and lumbar spine injury. Conclusion: Inconsistencies in results may be related to differences in study design, injury definitions, participant characteristics, measurement parameters, and statistical analyses. Low back pain and lumbar spine injury occurrence in fast bowlers remain high, and this may be due to an absence of low bias studies that have informed recommendations for their prevention. Future research should employ clearly defined injury outcomes, analyse continuous datasets, utilise models that better represent lumbar kinematics and kinetics during fast bowling, and better quantify previous injury, lumbar anatomical features and lumbar maturation. Trial registration: Open Science Framework https://doi.org/10.17605/OSF.IO/ERKZ2.


  • Open Access

    Bony Stress and Its Association With Intervertebral Disc Degeneration in the Lumbar Spine: A Systematic Review of Clinical and Basic Science Studies

    by Daniel Chepurin, Uphar Chamoli, Ashish D. Diwan

    Study Design: Translational review encompassing basic science and clinical evidence. Objectives: Multiple components of the lumbar spine interact during its normal and pathological function. Bony stress in the lumbar spine is recognized as a factor in the development of pars interarticularis defect and stress fractures, but its relationship with intervertebral disc (IVD) degeneration is not well understood. Therefore, we conducted a systematic review to examine the relationship between bony stress and IVD degeneration. Methods: Online databases Scopus, PubMed and MEDLINE via OVID were searched for relevant studies published between January 1980-February 2020, using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines. Two authors independently analyzed the data, noting characteristics and biases in various studies. Results: Thirty-two articles were included in the review: 8 clinical studies, 9 finite element modeling studies, 3 in-vivo biomechanical testing studies, and 12 in-vitro biomechanical testing studies. Of the 32 articles, 19 supported, 4 rejected and 9 made no conclusion on the hypothesis that there is a positive associative relationship between IVD degeneration and bony stress. However, sufficient evidence was not available to confirm or reject a causal relationship. Conclusions: Most studies suggest that the prevalence of IVD degeneration increases in the presence of bony stress; whether a causal relationship exists is unclear. The literature recommends early diagnosis and clinical suspicion of IVD degeneration and bony stress. Longitudinal studies are required to explore causal relationships between IVD degeneration and bony stress.


  • Open Access

    Bony Stress and Its Association With Intervertebral Disc Degeneration in the Lumbar Spine: a Review of Clinical and Basic Science Studies

    by Daniel Chepurin, Uphar Chamoli, Ashish D. Diwan

    BackgroundMultiple components of the lumbar spine interact during the normal and pathological function. Bony stress in the lumbar spine is recognised as a factor in the development of pars defects and stress fractures, but its relationship with intervertebral disc (IVD) degeneration is not well understood. Therefore, a translational review encompassing basic science and clinical evidence was conducted to examine the relationship between bony stress in the lumbar spine and IVD degeneration.MethodsOnline databases Scopus, PubMed and MEDLINE via OVID were searched for relevant studies published between January 1980 – February 2020, using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines. Two authors independently analysed the data, noting study characteristics and bias.ResultsThirty-two articles were included in the review: eight human studies, nine finite element analysis studies, three in-vivo biomechanical testing studies, and twelve in-vitro biomechanical testing studies. Of the 32 articles, 19 supported, four rejected and nine made no conclusion on the hypothesis that there is a positive associative relationship between IVD degeneration and bony stress. However, not enough evidence was available to confirm or reject a causal relationship.ConclusionMost studies suggest that the prevalence of IVD degeneration increases with the presence of bony stress, but whether a causal relationship exists is unclear. The literature recommends early diagnosis and clinical suspicion of IVD degeneration and bony stress. Longitudinal studies are required to explore causal relationships between IVD degeneration bony stress.

  • Smart orthopaedic implants: A targeted approach for continuous postoperative evaluation in the spine

    by Vivek A.S. Ramakrishna, Uphar Chamoli, Ginu Rajan, Subhas C. Mukhopadhyay, B. Gangadhara Prusty, Ashish D. Diwan


  • Complication rates of different discectomy techniques for symptomatic lumbar disc herniation: a systematic review and meta-analysis

    by Xiaolong Chen, Uphar Chamoli, Jose Vargas Castillo, Vivek A. S. Ramakrishna, Ashish D. Diwan

    Purpose This meta-analysis aims to compare the complication rates of discectomy/microdiscectomy (OD/MD), microendoscopic discectomy (MED), percutaneous endoscopic lumbar discectomy (PELD), percutaneous laser disc decompression (PLDD), and tubular discectomy for symptomatic lumbar disc herniation (LDH) using general classification and modified Clavien–Dindo classification (MCDC) schemes. Methods We searched three online databases for randomized controlled trials (RCTs) and cohort studies. Overall complication rates and complication rates per the above-mentioned classification schemes were considered as primary outcomes. Risk ratio (RR) and their 95% confidence intervals (CI) were evaluated. Results Seventeen RCTs and 20 cohort studies met the eligibility criteria. RCTs reporting OD/MD, MED, PELD, PLDD, and tubular discectomies had overall complication rates of 16.8% and 16.1%, 21.2%, 5.8%, 8.4%, and 25.8%, respectively. Compared with the OD/MD, there was moderate-quality evidence suggesting that PELD had a lower risk of overall complications (RR = 0.52, 95% CI 0.29–0.91) and high-quality evidence suggesting a lower risk of Type I complications per MCDC (RR = 0.37, 95% CI 0.16–0.81). Compared with the OD/MD data from cohort studies, there was low-quality evidence suggesting a higher risk of Type III complications per MCDC (RR = 10.83, 95% CI 1.29–91.18) for MED, higher risk of reherniations (RR = 1.67,95% CI 1.05–2.64) and reoperations (RR = 1.75, 95% CI 1.20–2.55) for PELD, lower risk of overall complication rates (RR = 0.42, 95% CI 0.25–0.70), post-operative complication rates (RR = 0.42, 95% CI 0.25–0.70), Type III complications per MCDC (RR = 0.39, 95% CI 0.22–0.69), reherniations (RR = 0.56, 95% CI 0.33–0.97) and reoperations (RR = 0.39, 95% CI 0.22–0.69) for PLDD. Conclusions Compared with the OD/MD, results of this meta-analysis suggest that PELD has a lower risk of overall complications and a lower risk of complications necessitating conservative treatment. Graphic abstract These slides can be retrieved under Electronic Supplementary Material.


  • Assessment of degenerative cervical stenosis on T2-weighted MR imaging: sensitivity to change and reliability of mid-sagittal and axial plane metrics

    by Keerthana Sritharan, Uphar Chamoli, Jeffrey Kuan, Ashish D. Diwan

    Study design A retrospective cross-sectional study. Objective To assess the sensitivity to change and reliability of various mid-sagittal and axial plane metrics in the assessment of patients with single-level degenerative cervical stenosis on T2-weighted MR imaging. Setting A diagnostic MR imaging facility in Sydney (Australia). Methods We retrospectively reviewed T2-weighted MR images of 85 consecutive patients (48 M and 37 F) with single-level degenerative cervical stenosis. Canal compromise and cord compression were evaluated using three mid-sagittal plane metrics (M1, M2, and M3) and two axial plane metrics (M4 and M5), at the level of stenosis and nonstenotic cephalad and caudal levels (controls). Sensitivity to change (SC) for each metric was evaluated as the percentage deviation of the measured value from the estimated normal value based on cephalad and caudal controls. Reliability for each metric was evaluated using intraclass correlation coefficients. Results Degenerative cervical stenosis showed a bimodal distribution peaking at C5-6 (n = 32) and C3-4 (n = 29) levels. The changes in the canal and cord geometry along the rostrocaudal axis were inconsistent. Across all individual subjects (reflecting a range of stenosis severity), M3 (−32.87% ± 10.60%) was more sensitive to change compared with M1 (16.64% ± 16.48%) and M2 (−23.95% ± 11.12%). Similarly, M4 (−24.62% ± 12.17%) was more sensitive to change compared with M5 (−6.71% ± 11.08%). The level of reliability was “moderate” to “excellent” for mid-sagittal plane measurements, and “poor” to “excellent” for axial plane measurements. Conclusion Changes in canal dimensions in the mid-sagittal plane and cord shape in the axial plane are sensitive indicators of degenerative cervical stenosis on T2-weighted MR images.


  • Complication rates of different discectomy techniques for the treatment of lumbar disc herniation: a network meta-analysis

    by Xiaolong Chen, Uphar Chamoli, Samuel Lapkin, Jose Vargas Castillo, Ashish D. Diwan

    The aim of this network meta-analysis (NMA) was to compare the complication rates of discectomy/microdiscectomy, percutaneous laser disc decompression (PLDD), percutaneous endoscopic lumbar discectomy (PELD), microendoscopic discectomy (MED), and tubular discectomy for symptomatic lumbar disc herniation (LDH).


  • Bony stress in the lumbar spine is associated with intervertebral disc degeneration and low back pain: a retrospective case–control MRI study of patients under 25 years of age

    by Daniel Chepurin, Uphar Chamoli, Kyle Sheldrick, Samuel Lapkin, David Scott, Jeff Kuan, Ashish D. Diwan

    Purpose Abnormal stress in the lumbar vertebra, also known as bony stress, can be a precursor to degenerative changes which may manifest as low back pain (LBP). However, the prevalence of bony stress in the lumbar spine and its relationship with degenerative changes and LBP is unclear. The purpose of this study was to evaluate the prevalence of bony stress in the lumbar spine and its relationship with intervertebral disc (IVD) degeneration, facet osteoarthritis and LBP in patients under 25 years of age. Methods A retrospective case–control study of 130 patients under 25 years of age was conducted from a population of 493 patients who had lumbar MRI across three imaging centres over three years. A cohort of 55 consecutive patients with bony stress was identified. A control group of consecutive patients (n = 75) without bony stress was also selected from the population. Results Bony stress was prevalent in 11% (95% CI [8.4–14.5%]) of patients and was not diagnosed in 36% (95% CI [22–55%]) of these cases. Patients with bony stress had over twofold (OR 2.3, 95% CI [1.1–4.8]) and fivefold (OR 5.3, 95% CI [2.11–13.3]) higher likelihood of having IVD degeneration and LBP, respectively, when compared with the control group. Bony stress was not found to be associated with facet osteoarthritis. Conclusion Bony stress in the lumbar spine was prevalent in 11% of patients under 25 years of age. It was commonly undiagnosed in radiology reports (not reported in 36% of the cases). Being significantly associated and with an increased likelihood of IVD degeneration and LBP, we posit that bony stress is likely a symptomatic and clinically meaningful diagnostic entity in the assessment of LBP. Graphic abstract These slides can be retrieved under Electronic Supplementary Material.