Chunguang Yang

The formation of multidrug‐resistant barriers dominated by biofilms is a intelligent living of methicillin‐resistant Staphylococcus aureus (MRSA), resulting in refractory infections. Reactive oxygen species (ROS)‐related biocatalysis triggered by nanomaterials have demonstrated outstanding resistance‐free advantages, while the therapeutic effectiveness is limited by the output and permeability into biofilms. Thus, we introduce a Cu‐based nanoplatform (Cu/Cu ₂ O@C@P NPs) utilizing high‐performance photo‐thermoelectric catalysis (PTEC) strategy to target LuxS and Agr dual quorum sensing (QS) systems of MRSA, resulting in a customized destruction procedure for combat MRSA. Herein, heterointerfaces engineering Cu/Cu ₂ O as the core structure featured abundant Cu vacancies einforced the conductivity and photo‐thermoelectric transformation of nanocomposite, while the mesoporous graphite was designed as shell structure to optimize the thermal conductivity, ultimately achieving an ultrahigh photothermal conversion efficiency (69.44%) and efficient PTEC. Combining multimodal catalytic mechanisms, the generated high‐yield ROS degraded QS signals both of LuxS and Agr systems, manifesting in loosening biofilms and inhibiting efflux pumps. Eventually, Cu/Cu ₂ O@C@P NPs fundamentally curbed drug resistance to actualize the full‐stage obliteration of MRSA infection, preferentially mitigated inflammatory responses, and accelerated wound healing. Overall, this study represents the innovative nanoplatform design of PTEC therapy, and provides that binding QS as a promising strategy for combat drug‐resistant bacteria.