Temduang Limpaiboon
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Temduang Limpaiboon has a total of 88 co-authors. Here are the top co-authors by number of shared publications:
Ruethairat Sriraksa
19 shared publications- Robert Brown
Imperial College London
18 shared publications - Wei Dai
University of Hong Kong
18 shared publications - Afshan Siddiq
Genomics England, Queen Mary University of London, London, UK
17 shared publications Constanze Zeller
17 shared publications- Andrew J. Walley
Section of Molecular Biology, Institute of Medical and Biomedical Education, St George’s, University of London, London, UK
16 shared publications
Latest Publications
- Open Access
Apigenin Induces Apoptosis and Inhibits Migration in Human Cholangiocarcinoma Cells
Cholangiocarcinoma (CCA) is a rare and highly aggressive cancer of the biliary tract, associated with poor clinical outcomes due to late diagnosis, extensive metastasis, drug resistance, and limited treatment options. Apigenin, a natural flavonoid, has been found to exhibit anticancer properties in several types of human cancer cells. Therefore, apigenin may be relevant to developing chemotherapeutic agents for cancer treatment. In this study, we examined the effects of apigenin on cell viability, cell cycle distribution, apoptosis, and cell migration in human CCA cell lines (KKU-M055) under in vitro conditions. The results demonstrate that apigenin significantly suppressed specific CCA cell proliferation by inducing cell cycle arrest at the G2/M phase and promoting cell apoptosis in KKU-M055 cells while exhibiting low toxicity in immortalized MMNK1 cells. Apigenin enhanced apoptotic features, including nuclear fragmentation and the loss of mitochondrial membrane potential. Furthermore, apigenin induced the apoptosis of KKU-M055 cells in both extrinsic and intrinsic pathways by activating caspase-8, -9, and -3/7. Moreover, apigenin inhibited KKU-M055 migration. Our study suggests apigenin as a promising candidate for treating CCA, and these findings provide theoretical support for the further development and potential application of apigenin in clinical CCA therapy.
Open AccessApigenin Induces Apoptosis and Inhibits Migration in Human Cholangiocarcinoma Cells
Cholangiocarcinoma (CCA) is a rare and highly aggressive cancer of the biliary tract, associated with poor clinical outcomes due to late diagnosis, extensive metastasis, drug resistance, and limited treatment options. Apigenin, a natural flavonoid, has been found to exhibit anticancer properties in several types of human cancer cells. Therefore, apigenin may be relevant to developing chemotherapeutic agents for cancer treatment. In this study, we examined the effects of apigenin on cell viability, cell cycle distribution, apoptosis, and cell migration in human CCA cell lines (KKU-M055) under in vitro conditions. The results demonstrate that apigenin significantly suppressed specific CCA cell proliferation by inducing cell cycle arrest at the G2/M phase and promoting cell apoptosis in KKU-M055 cells while exhibiting low toxicity in immortalized MMNK1 cells. Apigenin enhanced apoptotic features, including nuclear fragmentation and the loss of mitochondrial membrane potential. Furthermore, apigenin induced the apoptosis of KKU-M055 cells in both extrinsic and intrinsic pathways by activating caspase-8, -9, and -3/7. Moreover, apigenin inhibited KKU-M055 migration. Our study suggests apigenin as a promising candidate for treating CCA, and these findings provide theoretical support for the further development and potential application of apigenin in clinical CCA therapy.
- Open Access
- 3 April 2023
- Published by American Association for Cancer Research (AACR)
Supplementary Table 5 from Aberrant DNA Methylation at Genes Associated with a Stem Cell-like Phenotype in Cholangiocarcinoma Tumors
PDF file - 334K, List of genes associated with hypermethylated CpG sites in 6 CCA compared to 6 matched adjacent normal samples.
- 3 April 2023
- Published by American Association for Cancer Research (AACR)
Open AccessSupplementary Table 5 from Aberrant DNA Methylation at Genes Associated with a Stem Cell-like Phenotype in Cholangiocarcinoma Tumors
PDF file - 334K, List of genes associated with hypermethylated CpG sites in 6 CCA compared to 6 matched adjacent normal samples.
- Open Access
- 3 April 2023
- Published by American Association for Cancer Research (AACR)
Supplementary Table 3 from Aberrant DNA Methylation at Genes Associated with a Stem Cell-like Phenotype in Cholangiocarcinoma Tumors
PDF file - 337K, List of genes associated with hypermethylated CpG sites in CCA compared to adjacent normal samples.
- 3 April 2023
- Published by American Association for Cancer Research (AACR)
Open AccessSupplementary Table 3 from Aberrant DNA Methylation at Genes Associated with a Stem Cell-like Phenotype in Cholangiocarcinoma Tumors
PDF file - 337K, List of genes associated with hypermethylated CpG sites in CCA compared to adjacent normal samples.
- Open Access
- 3 April 2023
- Published by American Association for Cancer Research (AACR)
Supplementary Table 3 from Aberrant DNA Methylation at Genes Associated with a Stem Cell-like Phenotype in Cholangiocarcinoma Tumors
PDF file - 337K, List of genes associated with hypermethylated CpG sites in CCA compared to adjacent normal samples.
- 3 April 2023
- Published by American Association for Cancer Research (AACR)
Open AccessSupplementary Table 3 from Aberrant DNA Methylation at Genes Associated with a Stem Cell-like Phenotype in Cholangiocarcinoma Tumors
PDF file - 337K, List of genes associated with hypermethylated CpG sites in CCA compared to adjacent normal samples.