Yiyue Jiang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Yiyue Jiang has a total of 12 co-authors. Here are the top co-authors by number of shared publications:
Atsuhiro Nakagawa
Graduate School of Medicine, Tohoku University, Sendai 980-8577, Japan
1 shared publicationAtsushi Yasumoto
Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Japan
1 shared publicationBaoshan Guo
Department of Chemistry, University of Tokyo, Tokyo 113-0033, Japan
1 shared publication- Cheng Lei
Wuhan University
1 shared publication - Hirofumi Kobayashi
Chan Zuckerberg Biohub, San Francisco, USA
1 shared publication - Keisuke Goda
Department of Chemistry, The University of Tokyo, Tokyo 113-0033, Japan
1 shared publication
Latest Publications
- 19 June 2017
- Published by Royal Society of Chemistry (RSC) in Lab on a Chip
- Vol. 17 (14) , 2426-2434
Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy
According to WHO, about 10 million new cases of thrombotic disorders are diagnosed worldwide every year. Thrombotic disorders, including atherothrombosis (the leading cause of death in the US and Europe), are induced by occlusion of blood vessels, due to the formation of blood clots in which aggregated platelets play an important role. The presence of aggregated platelets in blood may be related to atherothrombosis (especially acute myocardial infarction) and is, hence, useful as a potential biomarker for the disease. However, conventional high-throughput blood analysers fail to accurately identify aggregated platelets in blood. Here we present an in vitro on-chip assay for label-free, single-cell image-based detection of aggregated platelets in human blood. This assay builds on a combination of optofluidic time-stretch microscopy on a microfluidic chip operating at a high throughput of 10 000 blood cells per second with machine learning, enabling morphology-based identification and enumeration of aggregated platelets in a short period of time. By performing cell classification with machine learning, we differentiate aggregated platelets from single platelets and white blood cells with a high specificity and sensitivity of 96.6% for both. Our results indicate that the assay is potentially promising as predictive diagnosis and therapeutic monitoring of thrombotic disorders in clinical settings.
- 19 June 2017
- Published by Royal Society of Chemistry (RSC) in Lab on a Chip
- Vol. 17 (14) , 2426-2434
Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy
According to WHO, about 10 million new cases of thrombotic disorders are diagnosed worldwide every year. Thrombotic disorders, including atherothrombosis (the leading cause of death in the US and Europe), are induced by occlusion of blood vessels, due to the formation of blood clots in which aggregated platelets play an important role. The presence of aggregated platelets in blood may be related to atherothrombosis (especially acute myocardial infarction) and is, hence, useful as a potential biomarker for the disease. However, conventional high-throughput blood analysers fail to accurately identify aggregated platelets in blood. Here we present an in vitro on-chip assay for label-free, single-cell image-based detection of aggregated platelets in human blood. This assay builds on a combination of optofluidic time-stretch microscopy on a microfluidic chip operating at a high throughput of 10 000 blood cells per second with machine learning, enabling morphology-based identification and enumeration of aggregated platelets in a short period of time. By performing cell classification with machine learning, we differentiate aggregated platelets from single platelets and white blood cells with a high specificity and sensitivity of 96.6% for both. Our results indicate that the assay is potentially promising as predictive diagnosis and therapeutic monitoring of thrombotic disorders in clinical settings.