Behzad Zeynizadeh

This study investigates the development of a novel and environmentally friendly catalyst, Fe ₃ O ₄ @chitosan@Ni ₂ B nanocomposite, for synthesis of tetrahydrobenzo[ b ]pyrans.

In this research, we have developed diverse strategies for synthesizing potential h NMDA receptor allosteric modulators through reduction and one-pot reductive acetylation of nitro(hetero)arenes using a mesoporous zirconocene-containing nanocatalyst.

This study aimed to develop hybrid hydrogel beads as biocompatible scaffolds using chitosan (CS) and sodium alginate (Alg), incorporating varying concentrations of halloysite nanotubes (Hal) (3, 6, and 9% w/w) and cross-linked with Ca²+ ions. The synthesized hydrogels were thoroughly characterized using various analytical techniques, including FTIR, XRD, SEM/EDX, and TEM. The varying Hal concentrations significantly influenced the properties of the hydrogels, as evidenced by swelling behavior analysis, which revealed a decrease in swelling capacity with an increase in Hal content. The water uptake capacity was decreased along with an increase in the percentage of Hal in hydrogels. All hydrogels revealed a substantial water content exceeding 80%. The addition of Hal had a non-significant effect on the water retention abilities of the hydrogels. The hemolysis test showed good hemostatic properties of the hydrogels. Therefore, hydrogels showed hopeful application properties in biomedical applications.

In this research, new catalytic applications of the Fe₃O₄/f-MWCNT-CS-Glu/Ni^II nanocomposite have been introduced for the efficient reduction and one-pot two-step reductive Schotten–Baumann-type acetylation of nitroarenes in water.

Neurodegenerative diseases (NDs) are one of the prominent health challenges facing contemporary society, and many efforts have been made to overcome and (or) control it. In this research paper, we described a practical one-pot two-step three-component reaction between 3,4-dihydronaphthalen-1(2H)-one (1), aryl(or heteroaryl)glyoxal monohydrates (2a-h), and hydrazine monohydrate (NH₂NH₂•H₂O) for the regioselective preparation of some 3-aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnoline derivatives (3a-h). After synthesis and characterization of the mentioned cinnolines (3a-h), the in silico multi-targeting inhibitory properties of these heterocyclic scaffolds have been investigated upon various Homo sapiens-type enzymes, including hMAO-A, hMAO-B, hAChE, hBChE, hBACE-1, hBACE-2, hNQO-1, hNQO-2, hnNOS, hiNOS, hPARP-1, hPARP-2, hLRRK-2^(G2019S), hGSK-3β, hp38α MAPK, hJNK-3, hOGA, hNMDA receptor, hnSMase-2, hIDO-1, hCOMT, hLIMK-1, hLIMK-2, hRIPK-1, hUCH-L1, hPARK-7, and hDHODH, which have confirmed their functions and roles in the neurodegenerative diseases (NDs), based on molecular docking studies, and the obtained results were compared with a wide range of approved drugs and well-known (with IC₅₀, EC₅₀, etc.) compounds. In addition, in silico ADMET prediction analysis was performed to examine the prospective drug properties of the synthesized heterocyclic compounds (3a-h). The obtained results from the molecular docking studies and ADMET-related data demonstrated that these series of 3-aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines (3a-h), especially hit ones, can really be turned into the potent core of new drugs for the treatment of neurodegenerative diseases (NDs), and/or due to the having some reactionable locations, they are able to have further organic reactions (such as cross-coupling reactions), and expansion of these compounds (for example, with using other types of aryl(or heteroaryl)glyoxal monohydrates) makes a new avenue for designing novel and efficient drugs for this purpose.

In this study, a new nanocomposite consisting of Ni₂B nanoparticles anchored on magnetic functionalized multi-walled carbon nanotubes (Fe₃O₄/f-MWCNT/Ni₂B) was synthesized and successfully used for the preparation of bioactive 1,4-benzodiazepines.

In this research work, an Fe ₃ O ₄ / f -MWCNT-CS-Glu/Ni ^II hybrid nanocomposite was synthesized, characterized, and used as a new and efficient multi-task catalytic system for the green one-pot synthesis of diverse heterocyclic frameworks.

In this study, a crafted zirconocene complex on rGO@Fe ₃ O ₄ as a novel magnetic nanocatalyst was synthesized and then characterized using FT-IR, SEM, EDX, VSM, ICP-OES, TGA, BET and MS analyses.

Herein, a new cockscomb flower-like Fe₃O₄@SiO₂@KCC-1@MPTMS@Cu^IImesoporous nanocomposite was synthesized, characterized, and used in the green reduction and reductive acetylation of nitroarenes and one-pot synthesis of some coumarin compounds.