Malay Dolai

A fluorescent sensor, ( E )- N ′-(3-ethoxy-2-hydroxybenzylidene) picolinohydrazide (EVH), was designed and synthesized for the selective fluorescence recognition of Zn ²⁺ in semi-aqueous media.

A fluorescent probe (HMC) has been developed for the selective turn-on detection of Fe ³⁺ exhibiting significant fluorescence enhancement and a visible emission color change from colorless to green.

A fluorescent sensor BFC was designed and synthesized in order to identify the selective fluorescence recognition of Zn ²⁺ in semi-aqueous environments.

A new fluorescent probe, designated as (( E )-2-((2-hydroxy-3-methoxybenzylidene)amino)-2-(hydroxymethyl)propane-1,3-diol (HHP), was synthesized for selective detection of phosgene via a fluorescence-based cyclization mechanism.

The Co- and Ni-based complexes were synthesized via in situ reaction of 2-cyanopyrimidine and hydroxylamine that forms homologous dinuclear cationic structures having excellent OER performance.

Dihydroxycoumarins which are present in nature as natural products in medicinal plants used for herbal treatment, have numerous pharmacological and therapeutic potentials. They can be developed as promising components of treatment in various medicinal fields. Regardless of several advantages, they have a few disadvantages like low molecular weight and low solubility which lowers the appropriate bioavailability. The strategy is to identify effective intake with a carrier for oral drug delivery. In this paper, we synthesized daphnetin (7,8-dihydroxycoumarin) which has various medicinal properties in a pot-economical multicomponent domino fashion, and explored its biophysical interaction with cysteine protease enzyme bromelain for the very first time using steady-state fluorescence and temperature variation experimentally at pH 7.4 since it has a proven record of enhancing the efficacy of drugs. The binding constant (or stability constant) of the bromelain-daphnetin interaction is determined from the double-logarithmic plot at three different temperatures, 288K, 298K, and 308K. The change of enthalpy and entropy revealed the major forces of interaction. Thus, bromelain can be used as a drug carrier for daphnetin.

Colon cancer remains a major global health burden characterized by uncontrolled proliferation, oxidative stress, and poor responsiveness to conventional therapies, underscoring the need for biocompatible and targeted nanotherapeutic interventions. In this study, a novel pH-responsive human serum albumin-based nanocarrier, HSA-BA@PEG-LC NPs, was designed for the efficient and selective delivery of baicalein (BA) to colon cancer cells. Molecular docking analysis demonstrated strong binding affinities of BA with Hsp90 inhibitors and with human serum albumin (HSA), as well as a notable interaction between L-citrulline (LC) and the cationic amino acid transporter 1 (CAT-1), highlighting their potential roles in anticancer modulation. The engineered nanoparticles exhibited a uniform spherical morphology (232 nm), low polydispersity index (PDI < 0.3), and high colloidal stability (−27.21 mV). Spectroscopic analyses (FTIR and ¹H NMR) confirmed successful encapsulation of BA and PEG-LC surface conjugation, with an encapsulation efficiency of 86.62% and pH-dependent sustained release favoring acidic tumor conditions. In HCT-116 cells, HSA-BA@PEG-LC NPs demonstrated enhanced internalization, strong cytoplasmic accumulation, and pronounced cytotoxicity (IC₅₀ = 5.42 µg mL⁻¹), while maintaining safety toward normal lymphocytes. Mechanistically, treatment induced elevated ROS levels, GSH depletion, mitochondrial depolarization, nuclear condensation, cytoskeletal collapse, and G0/G1 cell-cycle arrest. Furthermore, the formulation displayed potent antioxidant activity across DPPH, NO, SOD, and lipid peroxidation assays, with IC₅₀ values approaching ascorbic acid, validating synergistic PEG-LC functionalization and HSA-mediated stabilization as a promising redox-driven nanoplatform for targeted colon cancer therapy.

A fluorescent chemodosimeter, DBA, has been developed for the selective detection of hydrazine via an irreversible reaction pathway that leads to fluorescence enhancement.

Sub-Kelvin μSQUID-EPR reveals unexpected spin interactions in Co( ii ) dimers, complementing conventional magnetic studies.